[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-350674-105":59,"doc-detail-350674-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","radium-from-discovery-to-the-present-day-narrative-review","Radium - from discovery to the present day - narrative review","","Following its discovery, radium was initially promoted as a therapeutic agent for many conditions, including skin disorders, allergies, visual problems, and joint pain. Later studies revealed substantial radiological toxicity and serious adverse effects on human health. More than a century after discovery, some radium isotopes still have limited medical use, especially for specific cancers. Radium absorption resembles calcium and leads to bone deposition; health harm depends on absorbed dose and exposure duration. Chronic exposure links to hematological abnormalities, cataracts, dental and jaw damage, bone cancer, and increased mortality, while modern radiobiology and radiation protection aim to improve safety.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radium-from-discovery-to-the-present-day-narrative-review/350674/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radium-from-discovery-to-the-present-day-narrative-review/350674.png","ImageObject",300,407,{"name":92,"@type":93},"PakDamar76","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why was radium originally used after its discovery?","Question",{"text":112,"@type":113},"Radium was initially promoted as a therapeutic agent for a wide range of conditions, including skin disorders, allergies, visual problems, and joint pain, and as a general health-enhancing remedy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What makes radium harmful to human health?",{"text":117,"@type":113},"Subsequent research showed significant radiological toxicity and harmful effects, with severity tied to the absorbed dose and duration of exposure.",{"name":119,"@type":110,"acceptedAnswer":120},"How does radium behave in the body and what health effects are associated with chronic exposure?",{"text":121,"@type":113},"After ingestion, radium is absorbed and behaves similarly to calcium, depositing in bone tissue. 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However, subsequent research demonstrated its significant radiological toxicity and harmful effects on human health. Despite these risks, more than a century after its discovery, certain radium isotopes continue to have limited medical applications, particularly in the treatment of specific cancers. Following ingestion, radium is absorbed into the body and behaves similarly to calcium, resulting in its deposition in bone tissue. A proportion of absorbed radium is eliminated through feces and urine, while the remaining fraction may persist in the skeleton and contribute to long-term internal radiation exposure. The severity and onset of adverse health effects are closely related to the absorbed dose and duration of exposure. Chronic exposure to elevated radium levels has been associated with hematological abnormalities, cataracts, dental and jaw damage, bone cancer, and increased mortality. Advances in radiobiology, radiation protection, and personalized medicine continue to improve the safety and effectiveness of radiation-based treatments. Modern radiotherapy, including selected applications involving targeted radionuclide therapy, requires a detailed understanding of radiation dose distribution, biological responses, and patient-specific factors. The optimization of re-irradiation strategies remains an important clinical challenge that requires careful assessment of previous radiation exposure, tissue tolerance, and potential risks. Because radium exposure can occur through ingestion, inhalation, or dermal contact, continued monitoring, appropriate regulatory frameworks, and access to specialized analytical methods remain essential components of public health protection. International cooperation and strengthened surveillance programs are needed to ensure the safe management of radium-containing materials and minimize potential health risks.  \nKeywords Radium · Toxicity · Sources · Radiotherapy · Public health · Preventive medicine  \n Angelika Edyta Charkiewicz [angelika.charkiewicz@umb.edu.pl](angelika.charkiewicz@umb.edu.pl)[ ](angelika.charkiewicz@umb.edu.pl)Ivana Djuricic[ivana.djuricic@pharmacy.bg.ac.rs](ivana.djuricic@pharmacy.bg.ac.rs)[ ](ivana.djuricic@pharmacy.bg.ac.rs)Vanja Todorovic [vanja.todorovic@pharmacy.bg.ac.rs](vanja.todorovic@pharmacy.bg.ac.rs)[ ](vanja.todorovic@pharmacy.bg.ac.rs)Jacek Nikliński [jacek.niklinski@umb.edu.pl](jacek.niklinski@umb.edu.pl)  \nJaime Conceição  \n[jmconceicao@ualg.pt](jmconceicao@ualg.pt)  \nBrizita Djordjevic  \n[brizita.djordjevic@pharmacy.bg.ac.rs](brizita.djordjevic@pharmacy.bg.ac.rs)  \n1 Department of Clinical Molecular Biology, Medical University of Bialystok, Waszyngtona Street 13, Bialystok 15-269, Poland  \n2 Department of Bromatology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, Belgrade 11221, Serbia  \n3 Faculty of Sciences and Technology, Universidade do Algarve, Faro 8005-139, Portugal  \n4 Algarve Biomedical Centre Research Institute (ABC-Ri), Universidade do Algarve, Faro 8005-139, Portugal  \n5 Centre for Interdisciplinary Studies (CEIS20), Universidade de Coimbra, Coimbra 3000-186, Portugal  \nIntroduction  \nRadium was discovered in 1898 by Marie SkłodowskaCurie and Pierre Curie in Paris while investigating the radioactivity of uranium-containing minerals. After many attempts, Marie Skłodowska-Curie isolated 1 dg of alm","cbCailvexulkxl6I","https://ap.wps.com/l/cbCailvexulkxl6I","pdf",2521884,21,"English","# Abstract\n# Keywords\n# Introduction","[{\"question\":\"Why was radium originally used after its discovery?\",\"answer\":\"Radium was initially promoted as a therapeutic agent for a wide range of conditions, including skin disorders, allergies, visual problems, and joint pain, and as a general health-enhancing remedy.\"},{\"question\":\"What makes radium harmful to human health?\",\"answer\":\"Subsequent research showed significant radiological toxicity and harmful effects, with severity tied to the absorbed dose and duration of exposure.\"},{\"question\":\"How does radium behave in the body and what health effects are associated with chronic exposure?\",\"answer\":\"After ingestion, radium is absorbed and behaves similarly to calcium, depositing in bone tissue. Chronic exposure to elevated levels is associated with hematological abnormalities, cataracts, dental and jaw damage, bone cancer, and increased mortality.\"}]","Radium - from discovery to the present day - narrative review | PDF",1790090557,53]