[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-448188-105":59,"doc-detail-448188-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","radiotherapy-vs-photodynamic-therapy-a-comparison-of-antitumor-effects-and-pulmonary-toxicity-in-preclinical-models","Radiotherapy vs. photodynamic therapy - a comparison of antitumor effects and pulmonary toxicity in preclinical models","","The study compares radiotherapy (RTx) and photodynamic therapy (PDT) for antitumor activity and lung safety using preclinical models of lung cancer associated with interstitial lung disease (ILD). Pre-existing ILD is described as a key risk for severe radiation pneumonitis after RTx, motivating alternative minimally invasive approaches. In mice, tumor-targeting performance and tumor-volume outcomes are evaluated after intervention with localized irradiation or PDT using a porphyrin-based agent and laser ablation. In rats, an ILD model is used to assess pulmonary toxicity via imaging, bronchoalveolar lavage cell analysis, and fibrosis pathology scoring.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radiotherapy-vs-photodynamic-therapy-a-comparison-of-antitumor-effects-and-pulmonary-toxicity-in-preclinical-models/448188/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radiotherapy-vs-photodynamic-therapy-a-comparison-of-antitumor-effects-and-pulmonary-toxicity-in-preclinical-models/448188.png","ImageObject",300,407,{"name":92,"@type":93},"Asher","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is radiotherapy riskier in ILD-associated lung cancer?","Question",{"text":113,"@type":114},"Pre-existing ILD is linked to a significant risk of developing symptomatic and severe radiation pneumonitis after radiotherapy, potentially leading to life-threatening lung inflammation and respiratory failure.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How were RTx and PDT administered in the mouse xenograft model?",{"text":118,"@type":114},"Mice were divided into control, RTx, and PDT groups. RTx used a single 20 Gy local irradiation, while PDT used an intravenous porphyrin-based nanoparticle followed by laser ablation at specified wavelength and energy density.",{"name":120,"@type":111,"acceptedAnswer":121},"What did the rat ILD model show about pulmonary toxicity?",{"text":122,"@type":114},"In the ILD rat model, BLM combined with RTx led to increased lung infiltrates on CT and higher bronchoalveolar lavage leukocyte counts, including neutrophils and macrophages, with worse fibrosis pathology scores compared with BLM plus PDT.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},448188,1790792152,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":41,"preview_page_count":4},687197207639,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Radiotherapy vs. photodynamic therapy: a comparison of antitumor effects and pulmonary toxicity in preclinical models  \nYoshihisa Hiraishi1^, Takamasa Koga1, Hiroyuki Ogawa1, Andrew Effat1, Lili Ding2, Juan Chen2, Jonathan Allen1, Takahiro Yanagihara1, Fumi Yokote1, Nicholas Bernards1, Masato Aragaki1, Kate Kazlovich1, Nadia Mohammed1, Tsukasa Ishiwata1, Yusuke Fujibayashi1, Akira Saito3^, Hidenori Kage3^, Jonathan Yeung1, Gang Zheng2, Kazuhiro Yasufuku1^  \n1Division of Thoracic Surgery, Toronto General Hospital, University Health Network, Toronto, ON, Canada; 2Department of Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Department of Respiratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan  \nContributions: (I) Conception and design: N Mohammed, Y Hiraishi; (II) Administrative support: None; (III) Provision of study materials or patients: J Chen, L Ding, Y Hiraishi; (IV) Collection and assembly of data: H Ogawa, T Koga, Y Hiraishi; (V) Data analysis and interpretation: J Allen, YHiraishi; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \nCorrespondence to: Kazuhiro Yasufuku, MD, PhD. Division of Thoracic Surgery, Toronto General Hospital, University Health Network, 200 Elizabeth Street, 9N-957, Toronto, ON M5G 2C4, [Canada. Email: kazuhiro.yasufuku@uhn.ca](Canada. Email: kazuhiro.yasufuku@uhn.ca).  \nBackground: Interstitial lung disease (ILD) and lung cancer are often associated, and ILD-associated lung cancer is a difficult condition to treat. Radiotherapy (RTx) is one of a standard therapeutic modalities for lung cancer, but pre-existing ILD is known to be a significant risk factor for developing severe radiation pneumonitis (RP) after treatment. In this context, there is a demand for alternative treatment modalities for ILD-associated localized lung cancer. Photodynamic therapy (PDT) is a minimally invasive treatment modality for lung cancer that can be performed endoscopically. In this study, we investigated proof-ofconcept animal studies comparing RTx vs. PDT for (I) anti-tumor effects in a mouse xenograft model; and (II)  \npulmonary toxicity in a rat ILD model.  \nMethods: For the mouse tumor study, NCr-Foxn1nu athymic mice were subcutaneously inoculated with A549 or H460 human lung cancer cells to unilateral thigh and followed for growth until 8–12 mm sized.  \nUltrasmall nanostructured nanoparticle porphylipoprotein (PLP) was used in this study. The mice were divided into three intervention groups; control, RTx, and PDT. RTx group received a single 20 Gy local irradiation, while PDT group received an intravenous PLP (4 mg/kg) 24 hours before treatment, followed by laser ablation (671 nm) at 100 J/cm2. For the rat ILD study, Sprague-Dawley immunocompetent rats were given an intratracheal single dose of bleomycin (BLM; 2 mg/kg) or vehicle control, and were followed up for 3 weeks to develop ILD. RTx group received a single 20 Gy irradiation, while PDT group had PLP administration (4 mg/kg), laser fiber delivered to the left lung base under computed tomography (CT) guidance with mechanical ventilation support and PDT performed at 100 J/cm2. Chest CT was evaluated  \nmonthly and an autopsy was done after 1-or 3-month follow-up.  \nResults: In the mouse xenograft model, PLP biodistribution showed the best tumor-to-contralateral background muscle ratio at 24 hours post-injection. In day 7, both RTx and PDT showed a significant tumor volume difference in A549 and H460 xenografts over control, while PDT showed a significant tumor volume difference in A549 xenograft compared to RTx. In rat ILD model, chest CT showed that BLM + RTx exhibited increased lung infiltrates at week 15 compared to BLM + PDT. Leukocyte cell fractionation of bronchoalveolar lavage at 15 weeks showed that BLM + RTx had significantly higher cell counts than BLM + PDT or control in total leukocyte, neutrophil, and macrophage. In Ashcroft’s lung fibrosis pathology score,  \n^","cbCaivOHdeH9P56q","https://ap.wps.com/l/cbCaivOHdeH9P56q","pdf",1748971,12,"English","# Introduction\n## Background\n# Methods\n## Mouse xenograft model\n## Rat ILD model\n# Results\n## Antitumor effects\n## Pulmonary toxicity and fibrosis\n# Conclusions\n# Keywords","[{\"question\":\"Why is radiotherapy riskier in ILD-associated lung cancer?\",\"answer\":\"Pre-existing ILD is linked to a significant risk of developing symptomatic and severe radiation pneumonitis after radiotherapy, potentially leading to life-threatening lung inflammation and respiratory failure.\"},{\"question\":\"How were RTx and PDT administered in the mouse xenograft model?\",\"answer\":\"Mice were divided into control, RTx, and PDT groups. RTx used a single 20 Gy local irradiation, while PDT used an intravenous porphyrin-based nanoparticle followed by laser ablation at specified wavelength and energy density.\"},{\"question\":\"What did the rat ILD model show about pulmonary toxicity?\",\"answer\":\"In the ILD rat model, BLM combined with RTx led to increased lung infiltrates on CT and higher bronchoalveolar lavage leukocyte counts, including neutrophils and macrophages, with worse fibrosis pathology scores compared with BLM plus PDT.\"}]","Radiotherapy vs. photodynamic therapy - a comparison of antitumor effects and pulmonary toxicity in preclinical models | PDF",1790725909]