[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-337388-105":59,"doc-detail-337388-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","radiotherapy-in-metastatic-bladder-cancer-review","Radiotherapy in metastatic bladder cancer - review","","A comprehensive review evaluates available and emerging radiotherapy evidence for symptom relief and disease control in metastatic bladder cancer. PubMed and Scopus studies from 1990 to 2023 were searched using radiotherapy or palliative radiation therapy alongside metastatic or advanced bladder cancer, excluding articles without English translation. Palliative radiotherapy effectively alleviates haematuria and pain, and can consolidate response in oligometastatic settings by ablating residual or resistant lesions. The immunomodulatory role of radiotherapy is also explored in combination with systemic therapies, with an overall emphasis on effectiveness, safety, and accessibility.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radiotherapy-in-metastatic-bladder-cancer-review/337388/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radiotherapy-in-metastatic-bladder-cancer-review/337388.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of this review on metastatic bladder cancer?","Question",{"text":112,"@type":113},"To review available and emerging evidence of radiotherapy for both symptom management and disease control in metastatic bladder cancer.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the literature evidence collected for this review?",{"text":117,"@type":113},"A search and cross-referencing were conducted in PubMed and Scopus using radiotherapy terms and metastatic/advanced bladder cancer terms from 1990 to 2023, excluding studies without English translation.",{"name":119,"@type":110,"acceptedAnswer":120},"What benefits does palliative radiotherapy provide in metastatic bladder cancer?",{"text":121,"@type":113},"It effectively alleviates haematuria and pain from primary and metastatic disease and is described as effective, safe, and accessible across clinical settings.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},337388,1790624100,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","World Journal of Urology (2024) 42:47  \n[https://doi.org/10.1007/s00345-023-04744-x](https://doi.org/10.1007/s00345-023-04744-x)  \nRadiotherapy in metastatic bladder cancer  \nSophie Ashley1 · Ananya Choudhury1,2,3 · Peter Hoskin1,2,4 · YeePei Song1 · Priyamvada Maitre1,5  \nReceived: 12 September 2023 / Accepted: 30 October 2023 / Published online: 20 January 2024 © The Author(s) 2024  \nAbstract  \nPurpose To review available and emerging evidence of radiotherapy for symptom management and disease control in metastatic bladder cancer.  \nMethods A literature search and subsequent cross-referencing were carried out for articles in the PubMed and Scopus databases using terms ‘radiotherapy’ OR‘palliative radiation therapy’ with ‘metastatic bladder cancer’ OR ‘advanced bladder cancer’ between 1990 and 2023, excluding articles with no English translation.  \nResults Palliative radiotherapy is an effective and accessible treatment for the alleviation of haematuria and pain due to the primary and metastatic disease. With growing recognition of oligometastatic disease state at diagnosis, response, or progression, radiotherapy can consolidate response by ablating residual or resistant lesions. Experience with other primary cancers supports positive impact of radiotherapy on disease control, quality of life, and survival in oligometastatic stage, without significant adverse effects. Alongside immune checkpoint inhibitors, fibroblast growth receptor inhibitors, and antibody–drug conjugates, the immunomodulatory potential of radiotherapy is being explored in combination with these systemic therapies for metastatic bladder cancer.  \nConclusion Radiotherapy is an effective, safe, and accessible treatment modality for palliation as well as disease control in various clinical settings of metastatic bladder cancer. Its role in oligometastatic stage in combination with systemic therapy is expected to expand with emerging evidence.  \nKeywords Metastatic bladder cancer · Oligometastatic bladder cancer · Bladder radiotherapy · Palliative radiotherapy  \nIntroduction  \nBladder cancer causes nearly 200,000 deaths each year globally [1] . About 10–15% patients with diagnosed with bladder cancer have metastatic spread at presentation [1, 2] .  \n* Priyamvada Maitre  \n[priyamvada.maitre@nhs.net](priyamvada.maitre@nhs.net); [priyamvadamaitre@gmail.com](priyamvadamaitre@gmail.com)  \n1 The Christie NHS Foundation Trust, Manchester, United Kingdom  \n2 Division of Cancer Sciences, University of Manchester, Manchester, United Kingdom  \n3 Manchester Biomedical Research Centre, Manchester, United Kingdom  \n4 Mount Vernon Cancer Centre, Northwood, United Kingdom  \n5 Present Address: Department of Radiation Oncology, Tata Memorial Hospital and Advanced Centre for Treatment Research and Education in Cancer (ACTREC), Homi Bhabha National Institute (HBNI), Ernest Borges Road, Parel, Mumbai, India  \nIn the UK, bladder cancer causes about 5000 deaths annually [3]. Lower socioeconomic strata are disproportionately affected, with 5-year overall survival of 46% versus 56% in the highest socioeconomic group [4] . Metastatic bladder cancer (MetBC) includes involvement of lymph nodes beyond the pelvis, or other visceral organs. The prognosis at this stage is dismal, with less than 10% patients surviving at five years from the diagnosis [5] . It also causes considerable morbidity, with urinary symptoms of recurrent or intractable haematuria, pelvic pain, dysuria, and obstructive renal failure. First-line treatment is platinum-based chemotherapy, cisplatin and gemcitabine combination recommended for patients with good renal function (glomerular filtration rate, GFR \u003C 60 mL/min) and performance status of 0–1 . Carboplatin is an accepted compromise for those with impaired renal function or worse performance status [3] . Five-year survival of up to 15% can be expected with cisplatin-based chemotherapy [6] . If the disease responds or stabilises with first-line chemotherapy, further m","cbCaik1GsOs49QkO","https://ap.wps.com/l/cbCaik1GsOs49QkO","pdf",547862,"English","# Abstract\n## Purpose\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Epidemiology and prognosis\n## First-line treatments and immunotherapy\n## Role of radiotherapy in metastatic disease\n# Radiotherapy for symptom palliation","[{\"question\":\"What is the main purpose of this review on metastatic bladder cancer?\",\"answer\":\"To review available and emerging evidence of radiotherapy for both symptom management and disease control in metastatic bladder cancer.\"},{\"question\":\"How was the literature evidence collected for this review?\",\"answer\":\"A search and cross-referencing were conducted in PubMed and Scopus using radiotherapy terms and metastatic/advanced bladder cancer terms from 1990 to 2023, excluding studies without English translation.\"},{\"question\":\"What benefits does palliative radiotherapy provide in metastatic bladder cancer?\",\"answer\":\"It effectively alleviates haematuria and pain from primary and metastatic disease and is described as effective, safe, and accessible across clinical settings.\"}]","Radiotherapy in metastatic bladder cancer - review | PDF",1790018951,25]