[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-detail-331740-en":59,"doc-seo-331740-105":79},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":5,"data":60},{"doc_id":61,"user_id":62,"nickname":63,"user_avatar":64,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":66,"doc_content":67,"file_id":68,"file_url":69,"file_type":70,"file_size":71,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":39,"language":72,"language_code":73,"site_id":74,"html_lang":73,"table_of_contents":75,"faqs":76,"seo_title":77,"seo_description":66,"update_tm":78,"read_time":46,"preview_page_count":4},331740,13056703020460,"Valentina","https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","Radiotherapy and prognostic factors in adnexal carcinomas - a retrospective study of 657 patients from the French CARADERM network","Background: Cutaneous adnexal carcinomas are rare and heterogeneous, and although surgery is first-line for localized disease, radiotherapy use and effectiveness have not been well established. Objectives: Analyze prognostic factors and outcomes in skin adnexal carcinomas using CARADERM database data. Methods: Retrospective data from all eligible patients with informative follow-up were analyzed in primary-resected, recurrent-complete-remission, and advanced/metastatic groups. Overall survival and recurrence/progression-free survival at 3 years were assessed with Cox regression.","DOI: 10.1111/jdv.20155  \nO R IG I N A L A R T I C L E  \nRadiotherapy and prognostic factors in adnexal carcinomas: A retrospective study of 657 patients from the French CARADERM network  \nRobin Zagala1,2  | Stephane Dalle3,4  | Marie Beylot-Barry2,5  | Nicolas Meyer6  | Philippe Saiag7,8  | Nora Kramkimel9 | Celeste Lebbe10,11  | Ouidad Zehou12  | Mona Amini-Adle13 | Jean-Jacques Grob14  | Jean-Philippe Arnault15 | Eve Maubec16,17  | Florence Granel-Brocard18 | Bernard Cribier19  | Gaelle Quereux20 |  \nFlorence Brunet-Possenti21  | Sophie Dalac22  | Olivier Dereure23  | Elodie Drumez24 | Laurent Mortier25,26  | Maxime Battistella11,27  | Thomas Jouary1   \nCorrespondence  \nRobin Zagala, Dermatology Department, Hôpital Saint-André, 1 rue Jean Burguet, 33000 Bordeaux, France.  \nEmail: [robin.zagala@chu-bordeaux.fr](robin.zagala@chu-bordeaux.fr)  \nAbstract  \nBackground: Cutaneous adnexal carcinomas are a heterogeneous group of rare neoplasms. Surgical excision is the first-line treatment in localized stage. The use and effectiveness of radiotherapy have not been thoroughly evaluated in these neoplasms. Objectives: The present work analyses prognostic factors on outcomes in skin adnexal carcinomas, based on data from the CARADERM (CAncers RAres DERMatologiques) database.  \nMethods: Data were collected retrospectively including demographic data, tumour types and therapeutic characteristics of all patients included in the CARADERM database, with at least one informative follow-up visit. Analyses were performed on three populations: patients with complete resection of the primary tumour (ADJ/primary population), patients achieving complete remission after complete resection of arecurrent tumour (ADJ/recurrent population) and patients with unresectable locally advanced or metastatic tumours (ADV/MET population). Overall and recurrence/ progression-free survivals at 3-year were analysed using Cox regression models. Results: Radiotherapy did not affect overall survival (OS) in the ADJ/primary population. Adjusted recurrence-free survival (RFS) was significantly lower in the radiotherapy group in ADJ/primary group. Older patients had significantly poorer OSand RFS. Tumour size and immunosuppression were significantly associated with poorer RFS only. Radiotherapy had no effect on OS and RFS in the ADJ/recurrent population. Age was the only factor associated with a poorer OS. Radiotherapy was significantly associated with longer progression-free survival (PFS) in age-sex adjusted analysis in the ADV/MET population, without effect on OS.  \nConclusions: Our study shows that age, tumour size and immunosuppression are significantly associated with survival in localized adnexal carcinomas. Radiotherapy may improve PFS in the ADV/MET population but not in localized and recurrent carcinomas after complete excision.  \nFor affiliations refer to page 592.  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2024 The Author(s). Journal of the European Academy of Dermatology and Venereology published by John Wiley & Sons Ltd on behalf of European Academy of Dermatology and Venereology.  \nINTRODUCTION  \nCutaneous adnexal carcinomas include many various types and subtypes of rare cutaneous neoplasms. These carcinomas present with differentiation towards the hair follicle, theeccrine and apocrine sweat glands and the sebaceous glands, respectively. This group displays over 20 histological subtypes according with the 2022 OMS classification.1  \nDue to their rarity and diversity, adnexal carcinomas are of difficult diagnosis and their therapeutic management remains unsettled. The absence of established guidelines is due to the lack of strong comparative evidence regarding treatment strategies, though surgery remains the first","cbCail5KztplEnCo","https://ap.wps.com/l/cbCail5KztplEnCo","pdf",513821,"English","en",105,"# Abstract\n## Background and Objectives\n## Methods\n## Results\n## Conclusions\n# Introduction\n## Disease overview and diagnostic challenges\n## Treatment uncertainty and study rationale\n## CARADERM network\n# Materials and Methods\n## Data source and case review process\n## Study population and eligibility","[{\"question\":\"What was the study aim regarding radiotherapy in cutaneous adnexal carcinomas?\",\"answer\":\"The study analyzed outcomes and prognostic factors in skin adnexal carcinomas and specifically evaluated the role of radiotherapy across different clinical groups.\"},{\"question\":\"How were patients grouped for outcome analyses?\",\"answer\":\"Analyses were performed for patients with complete resection of the primary tumor, patients achieving complete remission after resection of recurrent tumor, and patients with unresectable locally advanced or metastatic disease.\"},{\"question\":\"Which prognostic factors were associated with survival outcomes?\",\"answer\":\"Age, tumor size, and immunosuppression were significantly associated with survival measures, with older age linked to poorer overall and recurrence-free outcomes.\"}]","Radiotherapy and prognostic factors in adnexal carcinomas - a retrospective study of 657 patients from the French CARADERM network | PDF",1789994951,{"code":4,"msg":80,"data":81},"ok",{"site_id":74,"language":73,"slug":82,"title":65,"keywords":83,"description":66,"schema_data":84,"social_meta":138,"head_meta":140,"extra_data":142,"updated_unix":143},"radiotherapy-and-prognostic-factors-in-adnexal-carcinomas-a-retrospective-study-of-657-patients-from-the-french-caraderm-network","",{"@graph":85,"@context":137},[86,100,120],{"@type":87,"itemListElement":88},"BreadcrumbList",[89,93,95,98],{"item":90,"name":91,"@type":92,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":94,"name":9,"@type":92,"position":14},"https://docshare.wps.com/document/",{"item":96,"name":40,"@type":92,"position":97},"https://docshare.wps.com/document/research-report/",3,{"item":99,"name":65,"@type":92,"position":19},"https://docshare.wps.com/document/radiotherapy-and-prognostic-factors-in-adnexal-carcinomas-a-retrospective-study-of-657-patients-from-the-french-caraderm-network/331740/",{"url":99,"name":65,"@type":101,"image":102,"author":107,"headline":65,"publisher":109,"fileFormat":112,"inLanguage":73,"description":66,"dateModified":113,"datePublished":114,"encodingFormat":112,"isAccessibleForFree":115,"interactionStatistic":116},"DigitalDocument",{"url":103,"@type":104,"width":105,"height":106},"https://docshare.wps.com/thumbnails/radiotherapy-and-prognostic-factors-in-adnexal-carcinomas-a-retrospective-study-of-657-patients-from-the-french-caraderm-network/331740.png","ImageObject",300,407,{"name":63,"@type":108},"Person",{"url":90,"name":110,"@type":111},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":117,"interactionType":118,"userInteractionCount":34},"InteractionCounter",{"@type":119},"ViewAction",{"@type":121,"mainEntity":122},"FAQPage",[123,129,133],{"name":124,"@type":125,"acceptedAnswer":126},"What was the study aim regarding radiotherapy in cutaneous adnexal carcinomas?","Question",{"text":127,"@type":128},"The study analyzed outcomes and prognostic factors in skin adnexal carcinomas and specifically evaluated the role of radiotherapy across different clinical groups.","Answer",{"name":130,"@type":125,"acceptedAnswer":131},"How were patients grouped for outcome analyses?",{"text":132,"@type":128},"Analyses were performed for patients with complete resection of the primary tumor, patients achieving complete remission after resection of recurrent tumor, and patients with unresectable locally advanced or metastatic disease.",{"name":134,"@type":125,"acceptedAnswer":135},"Which prognostic factors were associated with survival outcomes?",{"text":136,"@type":128},"Age, tumor size, and immunosuppression were significantly associated with survival measures, with older age linked to poorer overall and recurrence-free outcomes.","https://schema.org",{"og:url":99,"og:type":139,"og:title":65,"og:site_name":110,"og:description":66},"article",{"robots":141,"canonical":99},"index,follow",{"doc_id":61,"site_id":74},1790510133]