[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376350-105":59,"doc-detail-376350-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","radiotherapeutic-modalities-and-advancements-in-the-treatment-of-cutaneous-malignancies","Radiotherapeutic Modalities and Advancements in the Treatment of Cutaneous Malignancies","","Cutaneous malignancies represent the most common cancers worldwide and create a rising public health burden. Surgical excision is the main curative option, while radiotherapy serves as effective adjuvant therapy for high-risk histopathologic features and a reliable alternative for inoperable disease or lesions in cosmetically or functionally sensitive sites. Advances such as brachytherapy and proton therapy enable tailored treatment by tumor depth, extent, and anatomy. Modern approaches show favorable local control and toxicity, though evidence remains fragmented due to small cohorts, varied methods, and limited follow-up, leaving evolving roles in complex settings.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radiotherapeutic-modalities-and-advancements-in-the-treatment-of-cutaneous-malignancies/376350/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radiotherapeutic-modalities-and-advancements-in-the-treatment-of-cutaneous-malignancies/376350.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-24","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is radiotherapy important in cutaneous malignancies?","Question",{"text":113,"@type":114},"Radiotherapy supports curative and adjuvant care, providing effective treatment for high-risk histopathologic features and serving as an organ-preserving option for inoperable disease or lesions in sensitive sites.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What radiotherapeutic advances are highlighted for skin cancer care?",{"text":118,"@type":114},"The review emphasizes brachytherapy and proton therapy as key advances, expanding treatment options and enabling tailored plans based on tumor depth, extent, and anatomical location.",{"name":120,"@type":111,"acceptedAnswer":121},"What limits the current evidence on radiotherapeutic approaches?",{"text":122,"@type":114},"Evidence remains fragmented because many studies involve small patient cohorts, heterogeneous methodologies, and limited follow-up durations.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},376350,1790580669,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":41,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","Review  \nRadiotherapeutic Modalities and Advancements in the Treatment of Cutaneous Malignancies  \nNoor Malik 1, Irini Yacoub 2,3, Kristin Hsieh 2,4, J. Isabelle Choi 3, Arpit Chhabra 2,4 and Charles B. Simone 2nd 2,3, *  \nAcademic Editors: Aimilios Lallasand Athanassios A. Kyrgidis  \nReceived: 18 August 2025  \nRevised: 11 September 2025  \nAccepted: 15 September 2025  \nPublished: 17 September 2025  \nCitation: Malik, N.; Yacoub, I.; Hsieh, K.; Choi, J.I.; Chhabra, A.; Simone, C.B., 2nd. Radiotherapeutic Modalities and Advancements in the Treatment of Cutaneous Malignancies.  \nJ. Clin. Med. 2025, 14, 6547. [https://](https://)[ ](https://)[doi.org/10.3390/jcm14186547](doi.org/10.3390/jcm14186547)  \n[Copyright:](Copyright:) © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 School of Medicine and Dentistry, University of Lancashire, Preston PR1 2HE, UK  \n2 New York Proton Center, New York, NY 10035, USA  \n3 Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA  \n4 Department of Radiation Oncology, Mount Sinai Medical Center, New York, NY 10029, USA  \n* Correspondence: [csimone@nyproton.com](csimone@nyproton.com)  \nAbstract  \nCutaneous malignancies represent the most common cancers worldwide and pose a growing public health burden. While surgical excision remains the primary curative modality, radiotherapy offers an effective adjuvant therapy for high-risk histopathologic features and an established, organ-preserving alternative for patients with inoperable disease or lesions in cosmetically or functionally sensitive sites. Advances in radiotherapeutic techniques, including brachytherapy and proton therapy, have expanded the therapeutic armamentarium, allowing tailored treatment based on tumor depth, extent, and anatomical location. Contemporary evidence highlights favorable local control and toxicity outcomes with modern radiation therapy approaches, yet data remain fragmented, with most studies limited by small cohorts, heterogeneous methodologies, and limited follow-up durations. Furthermore, the role of radiotherapy in complex scenarios, such as perineural invasion, recurrent disease, and previously irradiated fields, continues to evolve. This review synthesizesthe current literature on radiotherapeutic management of skin cancer, critically evaluates dosimetric and clinical outcomes across modalities, and identifies key gaps in evidence. Emphasis is placed on the need for prospective, multicenter investigations to better define comparative effectiveness, optimize dose-fractionation regimens, and integrate emerging technologies into clinical practice. Radiotherapy remains an indispensable modality in dermatological oncology, offering curative potential with preservation of cosmesis and function, yet its optimal utilization demands further high-quality research to refine patientselection and therapeutic strategies.  \nKeywords: cutaneous malignancies; skin cancer; non-melanoma skin cancer; malignant melanoma; radiotherapy; brachytherapy; electron beam therapy; proton therapy; immunotherapy  \n1. Introduction  \nCutaneous malignancies constitute the most prevalent cancer type globally [1,2] . Epidemiologic data reveal that over 5.4 million new cases of non-melanoma skin cancers (NMSCs) are diagnosed annually in the United States alone [3], with the incidence rising at an estimated rate of 2–3% per year [4] . The pathogenesis of skin cancers is primarily driven by the cumulative exposure to ultraviolet (UV) radiation, which induces unrepaired DNA damage in epidermal cells, thereby facilitating oncogenic mutations and uncontrolled  \ncellular proliferation [5] . The skin is structurally composed of two principal layers","cbCainuyVjaGKxUA","https://ap.wps.com/l/cbCainuyVjaGKxUA","pdf",396183,"English","# Abstract\n# Keywords\n# 1. Introduction\n## Epidemiology of cutaneous malignancies\n## Pathogenesis and skin structure\n## Subtypes and clinical behavior\n## Surgical excision and limitations","[{\"question\":\"Why is radiotherapy important in cutaneous malignancies?\",\"answer\":\"Radiotherapy supports curative and adjuvant care, providing effective treatment for high-risk histopathologic features and serving as an organ-preserving option for inoperable disease or lesions in sensitive sites.\"},{\"question\":\"What radiotherapeutic advances are highlighted for skin cancer care?\",\"answer\":\"The review emphasizes brachytherapy and proton therapy as key advances, expanding treatment options and enabling tailored plans based on tumor depth, extent, and anatomical location.\"},{\"question\":\"What limits the current evidence on radiotherapeutic approaches?\",\"answer\":\"Evidence remains fragmented because many studies involve small patient cohorts, heterogeneous methodologies, and limited follow-up durations.\"}]","Radiotherapeutic Modalities and Advancements in the Treatment of Cutaneous Malignancies | PDF",1790218321,76]