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Iron-based nanomaterials have attracted intense interest due to strong functionality, high biocompatibility, and their ability to integrate with radionuclides for precise, targeted delivery. This review highlights advances in radiolabeling strategies, multimodal imaging, and radionuclide-based combinations, including radiotherapy paired with PTT, MHT, PDT, immunotherapy, and chemodynamic therapy, and concludes with future research priorities.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radiolabeled-iron-based-nanomaterials-for-cancer-diagnosis-and-therapy-review/359199/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radiolabeled-iron-based-nanomaterials-for-cancer-diagnosis-and-therapy-review/359199.png","ImageObject",300,407,{"name":92,"@type":93},"Mia  ","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are radiolabeled iron-based nanomaterials receiving increasing attention for cancer care?","Question",{"text":112,"@type":113},"They are valued for excellent functionality and superior biocompatibility, and for enabling integration with radionuclides to support targeted delivery and multimodal cancer diagnosis and treatment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What methods are emphasized for radiolabeled iron-based nanomaterials in this review?",{"text":117,"@type":113},"The review focuses on radiolabeling methods, multimodal imaging, and combination approaches that pair radiotherapy with therapies such as PTT, MHT, PDT, immunotherapy, and chemodynamic therapy.",{"name":119,"@type":110,"acceptedAnswer":120},"What challenges limit radionuclide-based diagnosis and therapy?",{"text":121,"@type":113},"Key issues include resistance in some cancers, non-specific distribution, limited bioavailability, and ionization-induced damage to non-target organs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},359199,1790649984,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687207024478,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","International Journal of Nanomedicine  \nOpen Access Full Text Article REVIEW  \nRadiolabeled Iron-Based Nanomaterials for Cancer Diagnosis and Therapy  \nYan-Xi Ma*, Kun-Long Dai*, Na Sun, Song Zhang  \nDepartment of Nuclear Medicine, Xin Qiao Hospital, Army Medical University, Chong Qing, 400037, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Kun-Long Dai; Song Zhang, Email dai [18393814467@163.com](18393814467@163.com); [cqsydzs@tmmu.edu.cn](cqsydzs@tmmu.edu.cn)  \n\n| Abstract: Cancer remains one of the leading causes of death worldwide, with diagnosis and treatment continuing to pose significant challenges. In recent years, iron-based nanomaterials (iron oxide-based nanomaterials, iron-based complex conjugates) have garnered unprecedented attention due to their excellent functionality, superior biocompatibility and potential for multifunctional integration. Due to the non-specific nature of radionuclides. Their integration with nanomaterials offers promising opportunities for precise cancer diagnosis and effective treatment by enabling targeted delivery, controlled release, and synergistic combination therapies. This review systematically elucidates the latest advancements in radiolabeled iron-based nanomaterials for cancer diagnosis and therapy, with a focus on radiolabeling methods, multimodal imaging, and the combination of radiotherapy with various treatment modalities, including photothermal therapy (PTT), magnetic hyperthermia therapy (MHT), photodynamic therapy (PDT), immunotherapy (IT), and chemodynamic therapy (CDT) . Finally, the prospects for the development of radiolabeled iron-based nanomaterials are discussed, along with key research priorities for the future.\u003Cbr>Keywords: radionuclides, iron-based nanomaterials, multimodal imaging, combination therapy |\n| --- |\n| Introduction\u003Cbr>Cancer ranks as the second most common cause of mortality globally. According to World Health Organization (WHO) projections, global cancer incidence may increase by 60% within the next 20 years.1 The growing burden of cancer presents substantial challenges to both public health and economic systems, making early detection and effective treatment universally recognized priorities.2 While modern oncology has made significant advances, conventional diagnostic and therapeutic approaches face limitations due to tumor heterogeneity, drug resistance, and adverse effects. Current screening methods primarily rely on biomarkers and imaging techniques (eg, X-ray, ultrasound, MRI); however, definitive diagnosis often requires invasive biopsy or surgical sampling.\u003Cbr>The current options for cancer therapy modalities include surgery, chemotherapy, radiotherapy, immunotherapy, monoclonal antibodies, targeted therapy, photodynamic therapy, and laser ablation. However, each approach has inherent drawbacks.3 Conventional cancer treatment often entails surgical intervention, which serves as the first-line approach formost malignancies by enabling direct removal of the tumor. Despite its efficacy, surgery is associated with significant risks and considerable physical trauma. Chemotherapy induces severe systemic toxicity. External beam radiotherapy, though widely used, delivers suboptimal radiation doses to tumors due to energy absorption by surrounding healthy tissues, resulting in collateral damage.4,5 In contrast, internal radiotherapy (radionuclide therapy) offers a targeted approach by delivering cytotoxic radiation directly to tumors or their microenvironment. Unlike biological therapies that modulate signaling pathways, radionuclides induce tumor cell death via localized ionizing radiation, which induces DNA strand breaks.6,7 This method improves therapeutic precision while minimizing off-target effects.\u003Cbr>Radionuclides are categorized into diagnostic and therapeutic nuclides. Diagnostic radionuclides are essential for patient stratification planning, leading to enhanced outcomes in targeted radionuclid","cbCaisM9VtWqbP7h","https://ap.wps.com/l/cbCaisM9VtWqbP7h","pdf",10762243,26,"English","# Abstract\n# Introduction\n## Cancer burden and diagnosis limitations\n## Overview of cancer therapy modalities and drawbacks\n## Radionuclide therapy and its mechanisms\n## Diagnostic vs. therapeutic radionuclides","[{\"question\":\"Why are radiolabeled iron-based nanomaterials receiving increasing attention for cancer care?\",\"answer\":\"They are valued for excellent functionality and superior biocompatibility, and for enabling integration with radionuclides to support targeted delivery and multimodal cancer diagnosis and treatment.\"},{\"question\":\"What methods are emphasized for radiolabeled iron-based nanomaterials in this review?\",\"answer\":\"The review focuses on radiolabeling methods, multimodal imaging, and combination approaches that pair radiotherapy with therapies such as PTT, MHT, PDT, immunotherapy, and chemodynamic therapy.\"},{\"question\":\"What challenges limit radionuclide-based diagnosis and therapy?\",\"answer\":\"Key issues include resistance in some cancers, non-specific distribution, limited bioavailability, and ionization-induced damage to non-target organs.\"}]","Radiolabeled Iron-Based Nanomaterials for Cancer Diagnosis and Therapy - Review | PDF",1790136390,66]