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This case report describes cancer recurrence and tumor progression into the renal pelvis after cryoablation of a T1b renal cell carcinoma. A 70-year-old woman developed persistent gross hematuria; imaging confirmed local recurrence and renal pelvis invasion, leading to open radical nephrectomy. The discussion emphasizes heightened vigilance when post-ablation progression involves the renal pelvis, requiring individualized expertise.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/radical-nephrectomy-following-prior-cryoablation-for-renal-cell-carcinoma-a-case-report-and-literature-review/408053/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/radical-nephrectomy-following-prior-cryoablation-for-renal-cell-carcinoma-a-case-report-and-literature-review/408053.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition developed after prior cryoablation in this case report?","Question",{"text":113,"@type":114},"Local recurrence and tumor progression into the renal pelvis developed after cryoablation.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the recurrence detected and what symptoms did the patient have?",{"text":118,"@type":114},"The patient experienced persistent gross hematuria, and imaging revealed local recurrence with invasion of the renal pelvis.",{"name":120,"@type":111,"acceptedAnswer":121},"Why was radical nephrectomy chosen instead of repeat cryoablation?",{"text":122,"@type":114},"Progression involving the renal pelvis was rare and required heightened vigilance, with management tailored to achieve optimal oncological and functional outcomes.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},408053,1790740028,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","IJU Case Reports  \n CASE REPORT  OPEN ACCESS   \nRadical Nephrectomy Following Prior Cryoablation for Renal Cell Carcinoma: A Case Report and Literature Review  \nSpyridon Mitsios1  | Panagiotis Balaxis1 | Athanasios Klampatsas1 | Anastasia Nikolaidou2 | Gkatzos Stergios1 | Panagiotis Kousidis2 | Evangelos Petsatodis3 | George Moustakas1  \n1Department of Urology, Theageneio Cancer Hospital of Thessaloniki, Thessaloniki, Greece | 2Department of Diagnostic Pathology, Theageneio Cancer Hospital of Thessaloniki, Thessaloniki, Greece | 3Interventional Radiology Department, G. Papanikolaou General Hospital Thessaloniki, Thessaloniki, Greece  \nCorrespondence: Spyridon Mitsios ([contact@dr-mitsios.simplelogin.com](contact@dr-mitsios.simplelogin.com))  \nReceived: 15 September 2025 | Revised: 22 October 2025 | Accepted: 28 November 2025  \nKeywords: ablation techniques | carcinoma | cryosurgery | nephrectomy | recurrence | renal cell  \nABSTRACT  \nIntroduction: Small renal masses account for 48%–66% of renal cell carcinoma diagnoses, influencing management decisions for low-stage kidney disease. This report presents a case of cancer recurrence and tumor progression into the renal pelvis postcryoablation, managed with radical nephrectomy.  \nCase Presentation: A 70-year-old woman with a history of cryoablation for T1b renal cell carcinoma in the right kidney presented with persistent hematuria. Imaging revealed local recurrence and carcinoma invasion of the renal pelvis. The patient underwent open radical nephrectomy. Intraoperatively, the kidney was found adhered to the peritoneum and vena cava. The remaining elements of renal, hilar and adrenal anatomy showed no abnormalities. The postoperative course was uneventful. Conclusion: While local recurrences following cryoablation can often be safely retreated with cryoablation, progression involving the renal pelvis is rare and demands heightened vigilance and expertise. Tailored approaches, including radical nephrectomy and technical adaptability, are essential for achieving optimal oncological and functional outcomes.  \n1 | Introduction  \nRCC is increasingly detected at earlier stages due to advanced imaging techniques, resulting in a rise in diagnoses of small renal masses (≤4cm), now accounting for 48%–66% of new RCC diagnoses [1] . The standard approach for SRMs has traditionally been partial nephrectomy, aiming to preserve renal function and reduce morbidity [2, 3] . Cryoablation has emerged asa less invasive alternative for select renal masses (T1b ≤7 cm in greatest dimension), offering comparable oncologic outcomes in carefully selected patients [4–7] .  \n2 | Case Presentation  \nA 70-year-old female patient presented with persistent grosshematuria. The patient had a history of prior cryoablation, for T1b clear cell RCC in the right kidney 2 years earlier, arterial hypertension and paraneoplastic thrombocytosis. Initial precryoablation CT revealed a 5 cm tumor (T1b) without renal pelvis invasion. Based on a R.E.N.A.L. nephrometry score of 10 ph, partial nephrectomy complexity was high with a 21.9% likelihood of major complications [8]. Following multidisciplinary oncology tumor board review, cryoablation was selected as a less invasive procedure.  \n\n| Abbreviations: CT, computed tomography; EUA, European urology association; GFR, glomerular filtration rate; ISUP, international society of urological pathology; MRI, magnetic resonance imaging; NCCN, National comprehensive cancer network; PUJ, pelvic ureteric junction; RCC, renal cell carcinoma; SRMs, small renal masses; US, ultrasound; WHO, World health organization. |\n| --- |\n| This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.\u003Cbr>© 2025 The Author(s). IJU Case Reports published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Urological Association. |\n\nIJU Case Reports, 2026; 9","cbCaipqRVb53jWX1","https://ap.wps.com/l/cbCaipqRVb53jWX1","pdf",771269,"English","# Introduction\n# Case Presentation\n# Conclusion","[{\"question\":\"What condition developed after prior cryoablation in this case report?\",\"answer\":\"Local recurrence and tumor progression into the renal pelvis developed after cryoablation.\"},{\"question\":\"How was the recurrence detected and what symptoms did the patient have?\",\"answer\":\"The patient experienced persistent gross hematuria, and imaging revealed local recurrence with invasion of the renal pelvis.\"},{\"question\":\"Why was radical nephrectomy chosen instead of repeat cryoablation?\",\"answer\":\"Progression involving the renal pelvis was rare and required heightened vigilance, with management tailored to achieve optimal oncological and functional outcomes.\"}]","Radical Nephrectomy Following Prior Cryoablation for Renal Cell Carcinoma - A Case Report and Literature Review | PDF",1790577981,13]