[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-30941":3,"doc-seo-30941":21},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"update_tm":20},30941,1374391974585,"Genevieve","https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c",7,"Healthcare","Radiation Enteritis - USMLE Notes","Radiation enteritis develops when therapeutic ionizing radiation damages rapidly dividing intestinal tissue after radiotherapy for prostate cancer. The injury arises from DNA double-strand breaks and reactive oxygen species generated by water ionization, which disrupt mitosis and trigger apoptosis in susceptible cells, including intestinal crypt stem cells. Concurrent inflammatory signaling increases proinflammatory cytokines and recruits leukocytes, amplifying oxidative tissue damage. Clinically, progressive inflammation, edema, mucosal denudation, abdominal pain, and diarrhea typically appear weeks after treatment, with possible delayed fibrosis, strictures, adhesions, and bowel obstruction. Related mechanisms include oxidative-stress–responsive but radiation-inhibited ubiquitin-proteasome activity and its connections to cellular immune antigen processing.","cbCaikrS8xBgIw31","https://ap.wps.com/l/cbCaikrS8xBgIw31","pdf",11069852,1,1778363648,{"code":4,"msg":22,"data":23},"ok",{"site_id":24,"language":25,"slug":26,"title":13,"keywords":27,"description":14,"schema_data":28,"social_meta":62,"head_meta":64,"extra_data":66,"updated_unix":20},105,"en","radiation-enteritis-usmle-notes","",{"@graph":29,"@context":61},[30,47],{"@type":31,"itemListElement":32},"BreadcrumbList",[33,37,41,44],{"item":34,"name":35,"@type":36,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":38,"name":39,"@type":36,"position":40},"https://docshare.wps.com/document/","Document",2,{"item":42,"name":12,"@type":36,"position":43},"https://docshare.wps.com/document/healthcare/",3,{"item":45,"name":13,"@type":36,"position":46},"https://docshare.wps.com/document/radiation-enteritis-usmle-notes/30941",4,{"url":45,"name":13,"@type":48,"author":49,"headline":13,"publisher":51,"fileFormat":54,"description":14,"dateModified":55,"datePublished":55,"encodingFormat":54,"isAccessibleForFree":56,"interactionStatistic":57},"DigitalDocument",{"name":9,"@type":50},"Person",{"url":34,"name":52,"@type":53},"DocShare","Organization","application/pdf","2026-05-09",true,{"@type":58,"interactionType":59,"userInteractionCount":4},"InteractionCounter",{"@type":60},"ViewAction","https://schema.org",{"og:url":45,"og:type":63,"og:title":13,"og:site_name":52,"og:description":14},"article",{"robots":65,"canonical":45},"index,follow",{"doc_id":7,"site_id":24}]