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This systematic review evaluates quinoxaline derivatives, heterocyclic compounds with diverse structures and anticancer activity, and clarifies their therapeutic promise. Using PRISMA-guided searches in MEDLINE/PubMed and ScienceDirect from 2020–2024, 77 pharmacology studies were selected. Results show inhibition of topoisomerases, kinases, and other targets, with antiproliferative and pro-apoptotic effects across multiple cancer cell lines, supporting their value as targeted anticancer agents.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/quinoxaline-derivatives-in-cancer-therapy-insights-into-mechanisms-of-action-and-therapeutic-applications/362565/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/quinoxaline-derivatives-in-cancer-therapy-insights-into-mechanisms-of-action-and-therapeutic-applications/362565.png","ImageObject",300,407,{"name":92,"@type":93},"Maya Linwood","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23",true,{"@type":101,"interactionType":102,"userInteractionCount":8},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is the purpose of this systematic review?","Question",{"text":111,"@type":112},"To provide an updated analysis of quinoxaline derivatives’ anticancer potential, emphasizing mechanisms of action and therapeutic applications in oncology.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"How were studies selected for the review?",{"text":116,"@type":112},"Following PRISMA guidelines, searches were performed in MEDLINE/PubMed and ScienceDirect for studies published from 2020 to 2024, using relevant keywords to identify quinoxaline derivative anticancer studies.",{"name":118,"@type":109,"acceptedAnswer":119},"What key anticancer mechanisms are reported for quinoxaline derivatives?",{"text":120,"@type":112},"They inhibit cancer cell growth through multiple mechanisms, including suppression of topoisomerases and kinases, and they show antiproliferative and pro-apoptotic effects across several cancer cell lines.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},362565,1790190976,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},962084928432,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nBiomol Ther 34(2), 291-324 (2026)  \nQuinoxaline Derivatives in Cancer Therapy: Insights into Mechanisms of Action and Therapeutic Applications  \nJinan Alhuwayshil1, NoufAlnajim1, Sarah bin Dulaym1, Jehan Alamre2, Arwa Alsubait3,4, Afrah E Mohammed5,6 and Sahar S. Alghamdi1,3,7,*  \n1College of Pharmacy King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481,  \n2Department of Clinical Pharmacology, Faculty of Medicine, King Abdul-Aziz University, Jeddah 21589,  \n3Medical Research Core Facility and Platforms Department, King Abdullah International Medical Research Center (KAIMRC), Ministry of National Guard Health Affairs, Riyadh 11481,  \n4Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud Bin Abdulaziz University for Health Sciences, Riyadh 11481,  \n5Department of Biology, College of Science, Princess Nourah bint Abdulrahman University, Riyadh 11671,  \n6Microbiology and Immunology Unit, Natural and Health Sciences Research Center, Princess Nourah bint Abdulrahman University, Riyadh 47330,  \n7Ministry of the National Guard-Health Affairs, Riyadh 11426, Saudi Arabia  \nAbstract  \nCancer continues to be a leading cause of morbidity and mortality globally, which necessitates the development of more effective and less toxic therapies. Quinoxaline derivatives, a class of heterocyclic compounds with versatile chemical structures, have emerged as promising candidates for anticancer drug development. These derivatives exhibit a range of biological activities and have shown significant efficacy against various tumors. However, the therapeutic potential of quinoxaline derivatives, particularly in clinical applications, remains underexplored, highlighting the need for further research to optimize their use as anticancer agents. This systematic review aims to provide an updated analysis of quinoxaline derivatives’ anticancer potential, focusing on their mechanisms of action and therapeutic applications in oncology. Following PRISMA guidelines, a thorough search was conducted in MEDLINE/PubMed and Science Direct for studies from 2020 to 2024. Relevant keywords were used to identify studies on quinoxaline derivatives and their anticancer properties, resulting in the selection of 77 studies based on pharmacological activity and mechanisms. The review included 77 studies exploring various anticancer activities of quinoxaline derivatives. Key findings indicate that these compounds effectively inhibit cancer cell growth through multiple mechanisms, including the inhibition of topoisomerases, kinases, and other critical proteins involved in cancer progression. Additionally, they demonstrate strong antiproliferative and pro-apoptotic effects across several cancer cell lines, highlighting their broad therapeutic potential. Quinoxaline derivatives represent a promising class of compounds in anticancer therapy due to their diverse biological activities and multiple molecular targets. The development of these derivatives as targeted therapies holds the potential for more effective cancer treatments.  \nKey Words: Quinoxaline derivatives, Anticancer, Antiproliferative, Mechanism of action, Apoptosis, Antitumor activity  \nINTRODUCTION  \nCancer is globally recognized as a leading cause of mortality, affecting millions of individuals worldwide (World Health Organization, Regional Office for the Eastern Mediterranean, 2024) . A worrying increase in cancer mortality is anticipated  \nglobally, with an estimated 9.74 million deaths from all forms of cancer expected to occur in 2022 and 10.4 million deaths by 2025 (International Agency for Research on Cancer, 2024) . The most diagnosed cancers globally include breast, lung, colorectal, prostate, non-melanoma skin cancers, and stomach cancer, each impacting various body tissues and sys-  \n Open Access  [https://doi.org/10.4062/biomolther.2025.061](https://doi.org/10.4062/biomolther.2025.061)  \nThis is an Open Access article distributed under the terms of","cbCaie8o70udR6FR","https://ap.wps.com/l/cbCaie8o70udR6FR","pdf",2355702,34,"English","# Abstract\n# Introduction","[{\"question\":\"What is the purpose of this systematic review?\",\"answer\":\"To provide an updated analysis of quinoxaline derivatives’ anticancer potential, emphasizing mechanisms of action and therapeutic applications in oncology.\"},{\"question\":\"How were studies selected for the review?\",\"answer\":\"Following PRISMA guidelines, searches were performed in MEDLINE/PubMed and ScienceDirect for studies published from 2020 to 2024, using relevant keywords to identify quinoxaline derivative anticancer studies.\"},{\"question\":\"What key anticancer mechanisms are reported for quinoxaline derivatives?\",\"answer\":\"They inhibit cancer cell growth through multiple mechanisms, including suppression of topoisomerases and kinases, and they show antiproliferative and pro-apoptotic effects across several cancer cell lines.\"}]","Quinoxaline Derivatives in Cancer Therapy - Insights into Mechanisms of Action and Therapeutic Applications | PDF",1790148282,86]