[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-361950-105":59,"doc-detail-361950-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","quercetin-a-natural-ally-in-combating-breast-cancer","Quercetin: A Natural Ally in Combating Breast Cancer","","Breast cancer is among the most common cancers in women worldwide, with high incidence and mortality. Despite the fatality, a unified mechanistic and treatment framework for herbal medicines remains limited. This review evaluates quercetin, a natural flavonoid, by synthesizing 272 articles from PubMed, Google Scholar, and Web of Science. Quercetin shows multi-modal, multi-target activity—especially in TNBC—by regulating pathways including IGF1/IGF1R, PI3K/Akt/mTOR, Wnt/β-catenin, MAPK/ERK, and PTEN promoter demethylation. It also enhances chemotherapy through reduced toxicity and drug-resistance reversal, inducing apoptosis while suppressing proliferation, migration, invasion, and metastasis, positioning it as a strategic agent against complex breast cancer progression.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/quercetin-a-natural-ally-in-combating-breast-cancer/361950/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/quercetin-a-natural-ally-in-combating-breast-cancer/361950.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",14,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main objective of this review on quercetin?","Question",{"text":113,"@type":114},"To investigate and assess the mechanism and treatment potential of quercetin in breast cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was the evidence collected and how many relevant articles were retrieved?",{"text":118,"@type":114},"Articles published within five years were collected using PubMed, Google Scholar, and Web of Science with “breast cancer” and “quercetin” as keywords, yielding 272 relevant articles.",{"name":120,"@type":111,"acceptedAnswer":121},"Which molecular pathways are highlighted for quercetin’s anti-breast-cancer effects?",{"text":122,"@type":114},"Key highlighted pathways include IGF1/IGF1R, PI3K/Akt/mTOR, Wnt/β-catenin, MAPK/ERK cascades, and PTEN promoter demethylation, particularly in TNBC.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},361950,1790208209,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","International Journal of Nanomedicine  \nOpen Access Full Text Article REVIEW  \nQuercetin: A Natural Ally in Combating Breast Cancer  \nZi-Yun Wu , Kang-Yu Qiu , Yan-Jun Gai, Jia-Hui Wu, Bo-Xuan Zhou, Qing-Feng Shi   \nDepartment of Breast Disease Center, The First Affiliated Hospital of Nanchang University, The First Clinical Medical College of Nanchang University, Jiangxi Medical College, Nanchang, 330006, People’s Republic of China  \nCorrespondence: Bo-Xuan Zhou; Qing-Feng Shi, Email [zhoubx@ncu.edu.cn](zhoubx@ncu.edu.cn); [A1169627331@163.com](A1169627331@163.com)  \n\n| Abstract: Breast cancer is one of the most common cancers among women worldwide, exhibiting notably high incidence and mortality rates. Despite its high fatality, a comprehensive study that mechanism and treatment of herbal medicines has not yet been conducted. Quercetin, a natural flavonoid, exhibits multi-targeted therapeutic potential against breast cancer. The aim of this study is to investigate and assess the mechanism and treatment of quercetin in breast cancer. We collected articles published within five years using PubMed, Google Scholar, and Web of Science with “breast cancer” and “quercetin” as keywords. Correspondingly, a total of 272 relevant articles were retrieved. Quercetin exhibits multi-modal therapeutic potential in breast cancer through its ability to orchestrate diverse molecular mechanisms, particularly in TNBC, such as targeting IGF1/IGF1R pathway, PI3K/Akt/mTOR, Wnt/β-catenin, MAPK/ERK cascades, and PTEN promoter demethylation. Critically, quercetin demonstrates synergistic activity with chemotherapy by overcoming drug resistance and reducing toxicity. Its therapeutic efficacy arises from concurrently inducing apoptosis and inhibiting proliferation, migration, invasion and metastasis. This profile positions quercetin as a strategic agent against breast cancer’s complex pathophysiology, effectively disrupting breast cancer malignant progression.\u003Cbr>Keywords: quercetin, breast cancer, apoptosis, drug carrier, combination therapy |\n| --- |\n| Introduction\u003Cbr>Breast cancer, as one of the most common malignant tumors in women, accounts for approximately 2.3 million new cases globally each year, ranking at the forefront of the incidence and mortality spectrum of female cancers.1 Its development is influenced by a combination of multiple factors, including age, reproductive risks, exposure to exogenous hormones, lifestyle, and histological abnormalities of the breast tissue.2 Based on the expression patterns of hormone receptors (ER/PR/HER2), breast cancer can be classified into molecular subtypes such as luminal type, HER2 overexpression type, and basal-like type.3 The basal-like type mainly includes Triple-Negative Breast Cancer (TNBC), which is characterized by strong invasiveness, high rates of metastasis and recurrence, and a significantly worse prognosis compared to other subtypes.4 TNBC exhibits no responsiveness to HER2-directed therapies, which further restricts the range of treatment options available.5\u003Cbr>Traditional Chinese medicine (TCM) has demonstrated potential for multitarget regulation in the treatment of breast cancer. Its active components can exert antitumor effects by inhibiting tumor proliferation, inducing apoptosis, and modulating pathways related to metastasis, such as epithelial-mesenchymal transition and angiogenesis.6 For example, studies have shown that TCM can inhibit the epithelial-mesenchymal transition of renal tubular cells through the NF-κB/ Snail signaling pathway.7 Additionally, TCM has been found to modulate the immune microenvironment and inhibit key oncogenic signaling pathways such as PI3K/Akt and Wnt/β-catenin, which are crucial for tumor progression.8 Furthermore, TCM can enhance the sensitivity of chemotherapeutic drugs, thereby improving treatment efficacy.9 This multitarget and synergistic mechanism provides a novel therapeutic strategy for the intervention of breast cancer, especially for hormone re","cbCaikgB8LwbmUt1","https://ap.wps.com/l/cbCaikgB8LwbmUt1","pdf",5970025,23,"English","# Abstract\n# Introduction\n# Quercetin—History and Medicinal Use","[{\"question\":\"What is the main objective of this review on quercetin?\",\"answer\":\"To investigate and assess the mechanism and treatment potential of quercetin in breast cancer.\"},{\"question\":\"How was the evidence collected and how many relevant articles were retrieved?\",\"answer\":\"Articles published within five years were collected using PubMed, Google Scholar, and Web of Science with “breast cancer” and “quercetin” as keywords, yielding 272 relevant articles.\"},{\"question\":\"Which molecular pathways are highlighted for quercetin’s anti-breast-cancer effects?\",\"answer\":\"Key highlighted pathways include IGF1/IGF1R, PI3K/Akt/mTOR, Wnt/β-catenin, MAPK/ERK cascades, and PTEN promoter demethylation, particularly in TNBC.\"}]","Quercetin: A Natural Ally in Combating Breast Cancer | PDF",1790146112,58]