[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-378425-105":3,"doc-detail-378425-en":81,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","pyroptosis-shedding-light-on-the-mechanisms-and-links-with-cancers-review","Pyroptosis: shedding light on the mechanisms and links with cancers - Review","","Pyroptosis is a form of programmed cell death distinct from apoptosis and necrosis, marked by cell swelling, membrane perforation and lysis, chromatin DNA fragmentation, and release of intracellular proinflammatory mediators such as IL-1β, IL-18, ATP and HMGB1. Growing evidence shows pyroptosis induction in tumor cells can trigger strong inflammatory responses and cancer regression, while also potentially contributing to chemotherapy and radiotherapy side effects. This review systematically summarizes the molecular mechanisms and the latest evidence for pyroptosis-targeted antitumor therapies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/pyroptosis-shedding-light-on-the-mechanisms-and-links-with-cancers-review/378425/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/pyroptosis-shedding-light-on-the-mechanisms-and-links-with-cancers-review/378425.png","ImageObject",300,407,{"name":42,"@type":43},"4398046744996","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",14,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What distinguishes pyroptosis from other forms of cell death?","Question",{"text":63,"@type":64},"Pyroptosis is characterized by cell swelling, membrane rupture (membranolysis), DNA fragmentation, and release of proinflammatory contents such as IL-1β, IL-18, ATP and HMGB1.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is pyroptosis mechanistically driven?",{"text":68,"@type":64},"Pyroptosis commonly involves gasdermin-mediated lytic death, typically requiring caspase cleavage of gasdermin proteins, which enables pore formation and osmotic lysis.",{"name":70,"@type":61,"acceptedAnswer":71},"What is the relationship between pyroptosis and cancer?",{"text":72,"@type":64},"Inducing pyroptosis in tumor cells can elicit strong inflammatory responses and significant cancer regression, increasing interest in its potential use in clinical cancer therapy.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},378425,1790377827,{"code":4,"msg":82,"data":83},"success",{"doc_id":79,"user_id":84,"nickname":42,"user_avatar":11,"doc_module":4,"category_id":85,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":86,"file_id":87,"file_url":88,"file_type":89,"file_size":90,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":91,"language":92,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":93,"faqs":94,"seo_title":95,"seo_description":12,"update_tm":96,"read_time":97},4398046744996,7,"TYPE Review  \nPUBLISHED 02 November 2023 DOI 10.3389/fimmu.2023.1290885  \nOPEN ACCESS  \nEDITED BY  \nKeqiang Chen,  \nNational Cancer Institute at Frederick (NIH), United States  \nREVIEWED BY Ji-Xin Tang,  \nGuangdong Medical University, China Dipendra Khadka,  \nNADIANBIO Co. Ltd. Medicine and Pharmaceutical R&D, Republic of Korea  \n*CORRESPONDENCE Guo-ying Fang  \n [hfyfgya@163.com](hfyfgya@163.com)[ ](hfyfgya@163.com)Jun Li  \n [lj@ahmu.edu.cn](lj@ahmu.edu.cn)  \n†These authors have contributed equally to this work and share first authorship  \nRECEIVED 08 September 2023  \nACCEPTED 20 October 2023  \nPUBLISHED 02 November 2023  \nCITATION  \nYou H-m, Wang L, Meng H-w, Huang C, Fang G-y and Li J (2023)  \nPyroptosis: shedding light on the mechanisms and links with cancers.  \nFront. Immunol. 14:1290885 .  \ndoi: 10.3389/fimmu.2023.1290885  \nCOPYRIGHT  \n© 2023 You, Wang, Meng, Huang, Fang and Li. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nPyroptosis: shedding light on the mechanisms and links with cancers  \nHong-mei You 1†, Ling Wang 2†, Hong-wu Meng 3, Cheng Huang 4, Guo-ying Fang 1* and Jun Li 4*  \n1 Department of Pharmacy, Hangzhou Women’s Hospital, Hangzhou, China, 2 Department of Pharmacy, Shangyu People’s Hospital of Shaoxing, Shaoxing, China, 3 Department of Pharmacy, The First Affiliated Hospital of Anhui Medical University, Hefei, China, 4 Inflammation and Immune Mediated Diseases Laboratory of Anhui Province, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China  \nPyroptosis, a novel form of programmed cell death (PCD) discovered after apoptosis and necrosis, is characterized by cell swelling, cytomembrane perforation and lysis, chromatin DNA fragmentation, and the release of intracellular proinflammatory contents, such as Interleukin (IL) 8, IL-1b, ATP, IL- 1a, and high mobility group box 1 (HMGB1) . Our understanding of pyroptosis has increased over time with an increase in research on the subject: gasderminmediated lytic PCD usually, but not always, requires cleavage by caspases. Moreover, new evidence suggests that pyroptosis induction in tumor cells results in a strong inflammatory response and significant cancer regression, which has stimulated great interest among scientists for its potential application in clinical cancer therapy. It’s worth noting that the side effects of chemotherapy and radiotherapy can be triggered by pyroptosis. Thus, the intelligent use of pyroptosis, the double-edged sword for tumors, will enable us to understand the genesis and development of cancers and provide potential methods to develop novel anticancer drugs based on pyroptosis. Hence, in this review, we systematically summarize the molecular mechanisms of pyroptosis and provide the latest available evidence supporting the antitumor properties of pyroptosis, and provide a summary of the various antitumor medicines targeting pyroptosis signaling pathways.  \nKEYWORDS  \npyroptosis, gasdermin, caspase, cell death, cancers  \n1 Introduction  \nThe dynamic balance between cell proliferation and cell death plays a critical role in various physiological and pathological processes in multicellular organisms. Unlike accidental cell death, which is caused by mechanical and physicochemical stimulation, programmed cell death (PCD) can be precisely regulated by genetic and pharmacological factors. Pyroptosis is a recently discovered inflammatory, lytic type of PCD that requires  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \nthe participation of the membrane-rupturing gasdermin family. Pyroptosis is chara","cbCaik8vTBDYh5Bu","https://ap.wps.com/l/cbCaik8vTBDYh5Bu","pdf",3039968,17,"English","# Introduction\n# Molecular mechanisms of pyroptosis\n## Gasdermin family and pore formation\n## Caspase-mediated cleavage pathways\n# Pyroptosis in cancer progression and therapy\n## Antitumor benefits of pyroptosis induction\n## Treatment-related risks and side effects","[{\"question\":\"What distinguishes pyroptosis from other forms of cell death?\",\"answer\":\"Pyroptosis is characterized by cell swelling, membrane rupture (membranolysis), DNA fragmentation, and release of proinflammatory contents such as IL-1β, IL-18, ATP and HMGB1.\"},{\"question\":\"How is pyroptosis mechanistically driven?\",\"answer\":\"Pyroptosis commonly involves gasdermin-mediated lytic death, typically requiring caspase cleavage of gasdermin proteins, which enables pore formation and osmotic lysis.\"},{\"question\":\"What is the relationship between pyroptosis and cancer?\",\"answer\":\"Inducing pyroptosis in tumor cells can elicit strong inflammatory responses and significant cancer regression, increasing interest in its potential use in clinical cancer therapy.\"}]","Pyroptosis: shedding light on the mechanisms and links with cancers - Review | PDF",1790230028,43,{"code":4,"msg":82,"data":99},[100,104,108,112,117,122,125,130,135,138,142],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":109,"show_sort_weight":110,"slug":111},"Exam",70,"exam",{"id":113,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},5,"Comic",60,"comic",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},6,"Technology",50,"technology",{"id":85,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":123,"slug":124},40,"healthcare",{"id":126,"doc_module":4,"doc_module_name":25,"category_name":127,"show_sort_weight":128,"slug":129},8,"Research & Report",30,"research-report",{"id":131,"doc_module":4,"doc_module_name":25,"category_name":132,"show_sort_weight":133,"slug":134},9,"Religion & Spirituality",20,"religion-spirituality",{"id":133,"doc_module":4,"doc_module_name":25,"category_name":136,"show_sort_weight":133,"slug":137},"World Cup","world-cup",{"id":139,"doc_module":4,"doc_module_name":25,"category_name":140,"show_sort_weight":139,"slug":141},10,"Lifestyle","lifestyle",{"id":143,"doc_module":4,"doc_module_name":25,"category_name":144,"show_sort_weight":113,"slug":145},19,"General","general"]