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A 25-year-old previously healthy male developed acute fever, rigors, and petechial rash that rapidly progressed to extensive PF and septic shock. After targeted antibiotics and intensive supportive care, complications required debridement and multiple hyperbaric oxygen therapy sessions, preserving his limbs.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/purpura-fulminans-due-to-neisseria-meningitidis-septicemia-treated-with-adjunctive-hyperbaric-oxygen-therapy-a-case-report/459046/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/purpura-fulminans-due-to-neisseria-meningitidis-septicemia-treated-with-adjunctive-hyperbaric-oxygen-therapy-a-case-report/459046.png","ImageObject",300,407,{"name":92,"@type":93},"mieayamfan","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What condition does the case report focus on, and why is it dangerous?","Question",{"text":112,"@type":113},"The report focuses on purpura fulminans (PF) caused by Neisseria meningitidis septicaemia. PF is dangerous due to rapidly progressive skin necrosis and disseminated intravascular coagulation, often leading to severe complications.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did the patient’s symptoms progress after initial presentation?",{"text":117,"@type":113},"The patient presented with acute fever, rigors, and a diffuse petechial rash. Within hours, the rash progressed to extensive PF with signs of septic shock, and later advanced to ischemic and necrotic lesions.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatments were used, and how did they affect outcomes?",{"text":121,"@type":113},"The patient received prompt broadspectrum antibiotics and supportive care, followed by targeted antibiotic therapy and aggressive supportive measures. Because of severe complications, debridement and multiple hyperbaric oxygen therapy sessions were required, ultimately preserving his limbs.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},459046,1791116820,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090893677,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Review began 11/13/2025  \nReview ended 12/04/2025  \nPublished 12/09/2025  \n© Copyright 2025  \nBani Hammad et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98817  \nOpen Access Case Report  \nPurpura Fulminans Due to Neisseria meningitidis Septicemia Treated With Adjunctive Hyperbaric Oxygen Therapy: A Case Report  \nNoora Bani Hammad 1, Abdulla Alghatam 2 , Jawaher Aljalahma 3, Noora Albuainain 4  \n1. Medicine and Surgery, Bahrain Defence Force Hospital, Riffa, BHR 2. Dermatology, Bahrain Defence Force Hospital, Riffa, BHR 3. Dermatology, Salmaniya Medical Complex, Manama, BHR 4. Surgery, Bahrain Defence Force Hospital, Riffa, BHR  \nCorresponding author: Noora Bani Hammad, [noorabanihammad19@gmail.com](noorabanihammad19@gmail.com)  \nAbstract  \nNeisseria meningitidis, a pathogenic bacterium known for causing bacterial meningitis, can also lead to severe systemic infections, including septicaemia. Among the most severe manifestations of N. meningitidis septicaemia is purpura fulminans (PF), a life-threatening condition characterized by rapidly progressive skin necrosis and disseminated intravascular coagulation. We report a case of a previously healthy 25-year-old male who presented with an acute onset of fever, rigors, and a diffuse petechial rash. Within hours, the patient developed extensive PF, accompanied by signs of septic shock. Despite prompt initiation of broadspectrum antibiotics and supportive care, the patient 's condition rapidly deteriorated. Diagnostic evaluation revealed N. meningitidis as the causative agent of the septicaemia. The patient was treated with targeted antibiotic therapy and aggressive supportive measures. Despite these interventions, the patient experienced severe complications, including PF that ultimately required debridement and multiple hyperbaric oxygen therapy sessions, which preserved the patient 's limbs. This case highlights the aggressive nature of N. meningitidis septicaemia associated with PF, emphasizing the need for early recognition and immediate intervention. It underscores the importance of rapid diagnostic and therapeutic strategies to manage this critical condition effectively. The case also illustrates the potential for rapid deterioration and the challenges in managing such severe presentations of meningococcal infection.  \nCategories: Internal Medicine, Infectious Disease, Dermatology  \nKeywords: fulminans purpura, hyperbaric oxygen therapy (hbot), neisseria meningitidis (n. meningitidis), tissue necrosis, wound healing  \nIntroduction  \nNeisseria meningitidis is a Gram-negative encapsulated diplococcus and a major cause of bacterial meningitis, which carries high morbidity and mortality. While meningococcal infections primarily present as meningitis, they can also manifest as severe systemic infections, including meningococcal septicaemia.  \nPurpura fulminans (PF) is a rapidly progressing and potentially fatal condition characterized by widespread intravascular thrombosis, disseminated intravascular coagulation (DIC), and extensive skin necrosis. The condition often leads to multi-organ failure and requires immediate medical intervention [1] . Furthermore, PF is a rare manifestation amongst adults, with the majority of cases being cited as case reports and case series. It is seen in 10-20% of patients with meningococcal septicaemia, with the most common bacterial organisms being meningococcus and Streptococcus pneumoniae . In terms of the mortality rate, it is very high, going up to 60% in affected individuals [2] .  \nThe pathophysiology of PF involves the systemic activation of the coagulation cascade and subsequent vascular damage, resulting in a petechial rash that rapidly evolves into full-thickness skin necrosis and deep muscle damage [3] . Although","cbCaibz9Hq0DpYDo","https://ap.wps.com/l/cbCaibz9Hq0DpYDo","pdf",4781494,"English","# Abstract\n# Introduction\n# Case Presentation","[{\"question\":\"What condition does the case report focus on, and why is it dangerous?\",\"answer\":\"The report focuses on purpura fulminans (PF) caused by Neisseria meningitidis septicaemia. PF is dangerous due to rapidly progressive skin necrosis and disseminated intravascular coagulation, often leading to severe complications.\"},{\"question\":\"How did the patient’s symptoms progress after initial presentation?\",\"answer\":\"The patient presented with acute fever, rigors, and a diffuse petechial rash. Within hours, the rash progressed to extensive PF with signs of septic shock, and later advanced to ischemic and necrotic lesions.\"},{\"question\":\"What treatments were used, and how did they affect outcomes?\",\"answer\":\"The patient received prompt broadspectrum antibiotics and supportive care, followed by targeted antibiotic therapy and aggressive supportive measures. Because of severe complications, debridement and multiple hyperbaric oxygen therapy sessions were required, ultimately preserving his limbs.\"}]","Purpura Fulminans Due to Neisseria meningitidis Septicemia Treated With Adjunctive Hyperbaric Oxygen Therapy - A Case Report | PDF",1790755054,15]