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Early identification of malignant nodules can improve patient survival rates. Therefore, accurately distinguishing between benign and malignant pulmonary nodules is essential for optimizing patient management and enhancing the efficiency of healthcare resource utilization. Patient concerns: A 53-year-old male.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pulmonary-nodules-with-explosive-calcification-were-finally-diagnosed-as-lung-adenocarcinom-a-case-report/455088/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pulmonary-nodules-with-explosive-calcification-were-finally-diagnosed-as-lung-adenocarcinom-a-case-report/455088.png","ImageObject",300,407,{"name":92,"@type":93},"Well Done","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why are calcified pulmonary nodules clinically important to evaluate?","Question",{"text":113,"@type":114},"Accurate identification of pulmonary nodules is crucial because early recognition of malignancy can improve survival and supports appropriate treatment planning.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What diagnostic findings led to suspicion of lung cancer in this case?",{"text":118,"@type":114},"Contrast-enhanced CT showed a mass-like high-density lesion with lobulation, spiculation, pleural retraction, calcification within the lesion, mild enhancement, and additional nodules near the left lower lobe pleura, while tumor markers were negative.",{"name":120,"@type":111,"acceptedAnswer":121},"What treatment and molecular results were reported after surgery?",{"text":122,"@type":114},"The patient underwent thoracoscopic partial lobectomy and lymph node dissection; pathology confirmed invasive lung adenocarcinoma with intrapulmonary metastasis. Genetic testing identified ALK and AKT1 mutations, and the patient received targeted therapy with ensartinib.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},455088,1790954909,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},5909892210082,"https://ap-avatar.wpscdn.com/avatar/56001069da27c9f41e8?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789614185077863061","®  \n Clinical Case Report   \nPulmonary nodules with explosive calcification were finally diagnosed as lung adenocarcinom A case report  \nZhen Li, MDa , Min Song, MDa , Mingzhen Zhu, MDa , Yu Zhang, MDa , Luyuan Tian, MDa , Hongchuan Zhao, MDa ,*  \n\n| Abstract\u003Cbr>Rationale: Pulmonary nodules are a common lung condition, and accurately determining their nature is crucial for doctors to develop appropriate treatment plans. Early identification of malignant nodules can improve patient survival rates. Therefore, accurately distinguishing between benign and malignant pulmonary nodules is essential for optimizing patient management and enhancing the efficiency of healthcare resource utilization.\u003Cbr>Patient concerns: The patient is a 53-year-old male. During a routine health examination, a calcified pulmonary nodule was identified. Initially, the nodule was considered benign due to its characteristic calcification and stable appearance on imaging. Over an 8-month follow-up period, serial imaging studies demonstrated no significant changes in the size or morphology of the nodule. Despite the absence of progression, the patient expressed concern regarding the possibility of lung cancer, prompting further diagnostic evaluation.\u003Cbr>Diagnoses: Contrast-enhanced computed tomography scan revealed a mass-like high-density shadow in the anterior segment of the left upper lobe, with clear margins, measuring approximately 16 mm × 14 mm × 13 mm. The lesion is adjacent to the trachea and exhibits lobulation, spiculation, and pleural retraction. Calcification is present within the lesion, and blood vessels are seen entering it. The enhanced scan showed mild enhancement. Multiple nodules were observed near the pleura of the left lower lobe. All lung cancer-related tumor markers were negative. The patient underwent a thoracoscopic partial lobectomy (left upper and lower lobes) and thoracoscopic lymph node dissection. Postoperative pathology confirmed invasive lung adenocarcinoma with intrapulmonary metastasis.\u003Cbr>Interventions: The patient underwent surgical treatment, followed by genetic testing, which revealed anaplastic lymphoma kinase and AKT serine/threonine kinase 1 mutations. The patient is now receiving targeted therapy with ensartinib.\u003Cbr>Outcomes: The patient was discharged 7 days post-surgery and is now on ensartinib for targeted therapy, with regular follow-up examinations scheduled.\u003Cbr>Lessons: This case emphasizes that nodules with diffuse, popcorn-like calcification do not rule out the possibility of lung cancer. A comprehensive evaluation integrating multidimensional imaging features is necessary. For nodules with conflicting imaging characteristics, minimally invasive surgical resection remains valuable for diagnosis. This approach broadens our diagnostic perspective on calcified nodules, enhances clinicians’ understanding of lung adenocarcinoma, and reduces the rate of misdiagnosis.\u003Cbr>Abbreviation: CT = computed tomography. |\n| --- |\n| Keywords: lung adenocarcinoma, medical imaging, case report, pulmonary calcified nodule |\n\n1. Introduction  \nLung cancer is the leading cause of cancer-related deaths worldwide, accounting for 11.6% of all cancer diagnoses and 18.4% of cancer-related mortality in both men and women  \nglobally.[1] Even in the context of early-stage disease, the survival rate of lung cancer patients lags behind that of patients with other common cancers, such as colon, breast, and prostate cancer, with a persistently low 5-year survival rate. [2] Despite advances in diagnostic techniques (e.g., low-dose  \nThe authors have no funding and conflicts of interest to disclose. The datasets generated during and/or analyzed during the current study are available from the corresponding author on reasonable request.  \nAccording to our institutional guidelines, ethical review is not required for reporting an individual case, and the family member of the patient provided informed consent for its publication.  \na Affiliated Hospita","cbCaiacyNHhnKue8","https://ap.wps.com/l/cbCaiacyNHhnKue8","pdf",756365,"English","# Introduction\n## Case presentation\n## Diagnosis\n## Interventions\n## Outcomes\n## Lessons\n## Abbreviation","[{\"question\":\"Why are calcified pulmonary nodules clinically important to evaluate?\",\"answer\":\"Accurate identification of pulmonary nodules is crucial because early recognition of malignancy can improve survival and supports appropriate treatment planning.\"},{\"question\":\"What diagnostic findings led to suspicion of lung cancer in this case?\",\"answer\":\"Contrast-enhanced CT showed a mass-like high-density lesion with lobulation, spiculation, pleural retraction, calcification within the lesion, mild enhancement, and additional nodules near the left lower lobe pleura, while tumor markers were negative.\"},{\"question\":\"What treatment and molecular results were reported after surgery?\",\"answer\":\"The patient underwent thoracoscopic partial lobectomy and lymph node dissection; pathology confirmed invasive lung adenocarcinoma with intrapulmonary metastasis. Genetic testing identified ALK and AKT1 mutations, and the patient received targeted therapy with ensartinib.\"}]","Pulmonary nodules with explosive calcification were finally diagnosed as lung adenocarcinom: A case report | PDF",1790742087,15]