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After hysterectomy and adjuvant chemotherapy for Stage IIIC1 endometrial cancer, chest CT initially showed a right upper-lobe ground-glass nodule interpreted as inflammatory scarring. Two years later, an adjacent ground-glass nodule emerged, gradually enlarged, and showed partial collision. Right upper lobectomy enabled histologic confirmation of acinar adenocarcinoma and metastatic endometrial cancer, supported by immunohistochemistry and serial CT evidence.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pulmonary-collision-tumor-comprising-lung-adenocarcinoma-and-metastatic-endometrial-cancer-a-case-report/345757/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pulmonary-collision-tumor-comprising-lung-adenocarcinoma-and-metastatic-endometrial-cancer-a-case-report/345757.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-22",true,{"@type":101,"interactionType":102,"userInteractionCount":14},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What is a pulmonary collision tumor described in this case report?","Question",{"text":111,"@type":112},"It is characterized by close apposition or partial intermingling of two histologically distinct neoplastic entities within the same anatomical site, here involving lung adenocarcinoma and metastatic endometrial cancer.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"What did chest CT show before the final diagnosis?",{"text":116,"@type":112},"CT first revealed a right upper-lobe ground-glass nodule thought to be an inflammatory scar, followed two years later by a second adjacent ground-glass nodule that gradually enlarged and partially collided with the first.",{"name":118,"@type":109,"acceptedAnswer":119},"How was the diagnosis confirmed after surgery?",{"text":120,"@type":112},"Right upper lobectomy and histopathology demonstrated acinar adenocarcinoma for the first lesion and metastatic endometrial cancer for the second, supported by immunohistochemical marker patterns (including TTF-1 for primary lung adenocarcinoma and PAX-8/HNF1β for metastatic endometrial origin).","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},345757,1790111557,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":138,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":139,"faqs":140,"seo_title":141,"seo_description":67,"update_tm":142,"read_time":143},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Thoracic Cancer  \nCASE REPORT  OPEN ACCESS   \nPulmonary Collision Tumor Comprising Lung Adenocarcinoma and Metastatic Endometrial  \nCancer: A Case Report  \nMomoko Asami1  | Hayato Konno1  | Shinya Katsumata1 | Hideaki Kojima1 | Naoya Yokomakura1 | Mitsuhiro Isaka1 | Nobuhiro Kado2 | Takuya Kawata3 | Masahiro Endo4 | Yasuhisa Ohde1  \n1Division of Thoracic Surgery, Shizuoka Cancer Center, Shizuoka, Japan | 2Division of Gynecology, Shizuoka Cancer Center, Shizuoka, Japan | 3Division of Pathology, Shizuoka Cancer Center, Shizuoka, Japan | 4Division of Diagnostic Radiology, Shizuoka Cancer Center, Shizuoka, Japan  \nCorrespondence: Hayato Konno ([h.konno@scchr.jp](h.konno@scchr.jp))  \nReceived: 4 September 2025 | Revised: 7 June 2026 | Accepted: 17 June 2026  \nKeywords: collision tumor | endometrial cancer | lung adenocarcinoma  \nABSTRACT  \nWe report a rare case of a 78-year-old woman with a collision tumor composed of primary lung adenocarcinoma and metastatic endometrial cancer. The patient previously underwent hysterectomy and adjuvant chemotherapy for Stage IIIC1 endometrial cancer. Chest computed tomography (CT) revealed a ground-glass nodule in the right upper lobe, which was suspected to be inflammatory scarring. Two years later, new adjacent nodules emerged, both of which gradually increased in size and exhibited partial collisions. A lobectomy was performed to detect multiple synchronous lung cancers. Histological features of the surgical specimens included acinar adenocarcinoma and metastatic lung tumors of endometrial cancer. To the best ofour knowledge, this is the first report of a pulmonary collision tumor consisting ofa lung adenocarcinoma and a metastatic lung tumor of endometrial cancer, with serial CT imaging successfully capturing the collision between the two lesions.  \n1 | Introduction  \nCollision tumors represent a rare subset of synchronous multiple primary malignancies characterized by the close apposition or partial intermingling of two histologically distinct neoplastic entities within the same anatomical site. Herein, we report a case of a pulmonary collision tumor comprising primary lung adenocarcinoma and a metastatic lung lesion originating from endometrial cancer.  \n2 | Case Presentation  \nA 78-year-old woman underwent hysterectomy following the diagnosis of endometrial cancer and subsequently received postoperative adjuvant chemotherapy for pT2N1M0 Stage IIIC1 disease. The patient had no history of smoking or malignancies  \nother than endometrial cancer. At the time of the endometrial cancer diagnosis, chest computed tomography (CT) revealed aground-glass nodule in the upper lobe of the right lung (the first lesion) . The nodule exhibited contractile changes and was initially considered to be an inflammatory scar. Consequently, the patient underwent surveillance with chest CT every 6 months.  \nTwo years after surgery for endometrial cancer, follow-up CT revealed the emergence of a new ground-glass nodule (second lesion) adjacent to the first lesion. Both nodules gradually increased in size during the observation period and partially collided (Figure 1) . The first lesion appeared as a solid lesion with relatively well-defined margins on chest CT. In contrast, the second lesion demonstrated a faint ground-glass opacity with slightly indistinct margins. During the follow-up period, the ground-glass nodule showed interval changes, including a gradual increase in internal attenuation while maintaining a  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s) . Thoracic Cancer published by John Wiley & Sons Australia, Ltd.  \nThoracic Cancer, 2026; 17:e70339 1 of 5  \n[https://doi.org/10.1111/1759-7714.70339](https://doi.org/10.1111/1759-7714.70339)  \nFIGURE 1 | (A) Chest CT scan showing the appearance of a second lesion (▷ ) adjacent to th","cbCaieB2hwlxCbTJ","https://ap.wps.com/l/cbCaieB2hwlxCbTJ","pdf",684466,"English","# Introduction\n# Case Presentation","[{\"question\":\"What is a pulmonary collision tumor described in this case report?\",\"answer\":\"It is characterized by close apposition or partial intermingling of two histologically distinct neoplastic entities within the same anatomical site, here involving lung adenocarcinoma and metastatic endometrial cancer.\"},{\"question\":\"What did chest CT show before the final diagnosis?\",\"answer\":\"CT first revealed a right upper-lobe ground-glass nodule thought to be an inflammatory scar, followed two years later by a second adjacent ground-glass nodule that gradually enlarged and partially collided with the first.\"},{\"question\":\"How was the diagnosis confirmed after surgery?\",\"answer\":\"Right upper lobectomy and histopathology demonstrated acinar adenocarcinoma for the first lesion and metastatic endometrial cancer for the second, supported by immunohistochemical marker patterns (including TTF-1 for primary lung adenocarcinoma and PAX-8/HNF1β for metastatic endometrial origin).\"}]","Pulmonary Collision Tumor Comprising Lung Adenocarcinoma and Metastatic Endometrial Cancer: A Case Report | PDF",1790058799,13]