[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-376011-105":59,"doc-detail-376011-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","ptiv-complexes-as-anticancer-drugs-and-their-relationship-with-oxidative-stress-review","Pt(IV) Complexes as Anticancer Drugs and Their Relationship with Oxidative Stress - Review","","Despite ongoing advances, cancer remains a leading cause of death, and oxidative stress (OS) is a key pathogenic factor in its development. However, there is still no fast and simple blood-test approach to identify OS in cancer patients. This review evaluates whether Pt(IV) complexes can serve to assess blood oxidative stress indicators and support monitoring of cancer progression. Results from PubMed and Google Scholar analyses indicate favorable reactions between Pt(IV) and measurable serum antioxidants such as glutathione and ascorbic acid, suggesting diagnostic potential alongside therapeutic effects, while requiring further validation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ptiv-complexes-as-anticancer-drugs-and-their-relationship-with-oxidative-stress-review/376011/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ptiv-complexes-as-anticancer-drugs-and-their-relationship-with-oxidative-stress-review/376011.png","ImageObject",300,407,{"name":92,"@type":93},"นรินทร์","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":81},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is oxidative stress (OS) important in cancer?","Question",{"text":112,"@type":113},"OS is described as a crucial factor in cancer development and evolution, through intracellular generation of reactive oxygen species that disrupt genomic stability and signaling pathways.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What challenge does the review highlight for measuring OS in cancer patients?",{"text":117,"@type":113},"The review states there is currently no quick or easy way to identify OS in cancer patients using blood tests.",{"name":119,"@type":110,"acceptedAnswer":120},"How are Pt(IV) complexes proposed to relate to cancer management?",{"text":121,"@type":113},"Pt(IV) complexes are presented as anticancer prodrugs preferred over Pt(II) in certain respects, because intracellular reductants convert Pt(IV) into Pt(II) analogs with anti-carcinogenic effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},376011,1792666201,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":81,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336475104957,"https://ap-avatar.wpscdn.com/avatar/22000c4c6bd8a5076e1?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787554080175789136","Review  \nPt(IV) Complexes as Anticancer Drugs and Their Relationship with Oxidative Stress  \nVlad Iova 1, Radu Ciprian Tincu 1,2, Ioana Scrobota 3, * and Mihail Silviu Tudosie 1,2  \nAcademic Editor: Fabio Altieri  \nReceived: 8 February 2025  \nRevised: 6 April 2025  \nAccepted: 15 April 2025  \nPublished: 17 April 2025  \nCitation: Iova, V.; Tincu, R.C.; Scrobota, I.; Tudosie, M.S. Pt(IV) Complexes as Anticancer Drugs and Their Relationship with Oxidative Stress. Biomedicines 2025, 13, 981 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biomedicines13040981  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Faculty of Medicine,“Carol Davila” University of Medicine and Pharmacy Bucharest,  \n020021 Bucharest, Romania; [vlad.iova2022@stud.umfcd.ro](vlad.iova2022@stud.umfcd.ro) (V.I.); [radu.tincu@umfcd.ro](radu.tincu@umfcd.ro) (R.C.T.); [mihail.tudosie@umfcd.ro](mihail.tudosie@umfcd.ro) (M.S.T.)  \n2 ICU II Toxicology, Clinical Emergency Hospital, 014461 Bucharest, Romania  \n3 Department of Dental Medicine, Faculty of Medicine and Pharmacy, University of Oradea, 1st Decembrie Street, 410073 Oradea, Romania  \n* Correspondence: ioana_scrobota@uoradea.ro  \nAbstract: Despite continuous research, cancer is still a leading cause of death worldwide; therefore, new methods of cancer management improvement are emerging. It is well known that in the pathophysiology of cancer, oxidative stress (OS) is a significant factor. Nevertheless, there is currently no quick or easy way to identify OS in cancer patients using blood tests. Currently, in cancer treatments, Pt(IV) complexes are preferred to Pt(II) complexes in terms of adverse effects, drug resistance, and administration methods. Intracellular reductants convert Pt(IV) complexes to their Pt(II) analogs, which are Pt compounds with anti-carcinogenic effects. Our aim was to find out if Pt(IV) complexes could be used to assess blood oxidative stress indicators and, consequently, monitor the development of cancer. In this review, we analyzed previous research using the PubMed and Google Scholar public databases to verify the potential use of Pt(IV) complexes in cancer management. We found that two main serum antioxidants, glutathione and ascorbic acid, which are easily measured using conventional methods, react favorably with Pt(IV) complexes. Our research results suggest Pt(IV) complexes as therapeutic anticancer drugs and potential diagnosis agents. However, further research must be conducted to verify this hypothesis.  \nKeywords: oxidative stress; cancer; Pt(IV); anticancer prodrugs; glutathione; ascorbic acid  \n1. Introduction  \nCancer is the second leading cause of death globally after cardiovascular disease [1], according to estimates being responsible for 9.6 million deaths, or 1 in 6 deaths, in 2022 [2] .  \nAt present, cancer therapies imply different methods that, besides their advantages, often come with disadvantages like high invasiveness, postoperative morbidity and mortality, non-specificity, toxicity to the surrounding organs and tissues, drug resistance, limited data regarding the right dose, poor bioavailability, and high costs, respectively [3–14] .  \nAlthough therapeutic approaches have been developed over time, cancer incidence and mortality have not decreased [15] . Therefore, the improvement of knowledge on theetiopathogenetic mechanisms of cancer, early diagnosis techniques, and screening methods could contribute to better prevention and management in already-diagnosed cases.  \nThe development of cancer is linked to genetic dysregulation (acquired or congenital), tumor cells that bypass host immune responses, metabolic alterations and epigenetic modific","cbCaildaIqMScDSi","https://ap.wps.com/l/cbCaildaIqMScDSi","pdf",1773702,25,"English","# Abstract\n# Keywords\n# 1. Introduction","[{\"question\":\"Why is oxidative stress (OS) important in cancer?\",\"answer\":\"OS is described as a crucial factor in cancer development and evolution, through intracellular generation of reactive oxygen species that disrupt genomic stability and signaling pathways.\"},{\"question\":\"What challenge does the review highlight for measuring OS in cancer patients?\",\"answer\":\"The review states there is currently no quick or easy way to identify OS in cancer patients using blood tests.\"},{\"question\":\"How are Pt(IV) complexes proposed to relate to cancer management?\",\"answer\":\"Pt(IV) complexes are presented as anticancer prodrugs preferred over Pt(II) in certain respects, because intracellular reductants convert Pt(IV) into Pt(II) analogs with anti-carcinogenic effects.\"}]","Pt(IV) Complexes as Anticancer Drugs and Their Relationship with Oxidative Stress - Review | PDF",1790216993,63]