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Psoriasis is linked to increased AF risk through chronic systemic inflammation and elevated pro-inflammatory cytokines, including IL-6, IL-17, and tumor necrosis factor-alpha. These mediators promote atrial remodeling, fibrosis, and conduction abnormalities, with evidence from electrophysiological measures such as prolonged P-wave dispersion and atrial electromechanical delay. Observational data limit causal conclusions, motivating large-scale multicenter and mechanistic studies to improve early detection and management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/psoriasis-and-atrial-fibrillation-exploring-the-intersection/435069/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/psoriasis-and-atrial-fibrillation-exploring-the-intersection/435069.png","ImageObject",300,407,{"name":92,"@type":93},"4398046744996","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What relationship between psoriasis and atrial fibrillation does the review address?","Question",{"text":112,"@type":113},"The review examines an emerging connection between psoriasis and AF, highlighting shared inflammatory mechanisms and the clinical implications for AF risk in psoriatic patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which inflammatory mediators are emphasized as common contributors?",{"text":117,"@type":113},"It emphasizes chronic systemic inflammation and specific cytokines, including interleukin (IL)-6, IL-17, and tumor necrosis factor-alpha, as central to psoriasis pathology and AF risk.",{"name":119,"@type":110,"acceptedAnswer":120},"Why does the review call for further research?",{"text":121,"@type":113},"It notes reliance on observational studies, which limits definitive causal conclusions, and emphasizes the need for large-scale, multicenter work to validate mechanisms and identify genetic and lifestyle factors influencing AF burden.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},435069,1790716788,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":66,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},4398046744996,"| W | J | E | M | World Journal of\u003Cbr>Experimental Medicine |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Exp Med 2025 December 20; 15(4): 107425  \nDOI: 10.5493/wjem.v15.i4.107425 ISSN 2220-315x (online)  \nMINIREVIEWS  \nPsoriasis and atrial fibrillation: Exploring the intersection  \nHitaishi Mehta, Smriti Gupta, Juniali Hatwal, Aalam Sohal, Akash Batta, Bishav Mohan  \nSpecialty type: Medicine, research and experimental  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade B, Grade B, Grade B  \nNovelty: Grade A, Grade B, Grade B, Grade B  \nCreativity or Innovation: Grade A, Grade A, Grade B, Grade B Scientific Significance: Grade A, Grade A, Grade A, Grade B  \nP-Reviewer: Ji KK, MD, PhD, Chief Physician, Postdoctoral Fellow, Professor, China; Zhao K, MD,  \nProfessor, China  \nReceived: March 24, 2025  \nRevised: May 15, 2025  \nAccepted: August 13, 2025  \nPublished online: December 20, 2025  \nProcessing time: 271 Days and 14.9 Hours  \nHitaishi Mehta, Department of Dermatology, Sohana Hospital, Mohali, Punjab 140308, India  \nSmriti Gupta, Department of Internal Medicine, University of Maryland Medical Centre Midtown Campus, Baltimore, Baltimore, MD 21201, United States  \nJuniali Hatwal, Department of Internal Medicine, Post Graduate Institute of Medical Education and Research, Chandigarh 160012, India  \nAalam Sohal, Gastroenterology and Hepatology, Creighton University School of Medicine, Phoenix, AZ 85012, United States  \nAkash Batta, Bishav Mohan, Department of Cardiology, Dayanand Medical College and Hospital, Ludhiana 141001, Punjab, India  \nCorresponding author: Akash Batta, Associate Professor, Department of Cardiology, Dayanand Medical College and Hospital, Tagore Nagar, Civil Lines, Ludhiana 141001, Punjab, India.  \n[akashbatta02@gmail.com](akashbatta02@gmail.com)  \nAbstract  \nThis review explores the emerging connection between psoriasis and atrial fibrillation (AF), focusing on shared inflammatory mechanisms, clinical implications, and research gaps. Psoriasis, characterized by chronic systemic inflammation, has been associated with increased AF risk, driven by elevated pro-inflammatory cytokines such as interleukin (IL)-6, IL-17, and tumor necrosis factor-alpha. These inflammatory mediators contribute to atrial remodeling, fibrosis, and conduction abnormalities, evidenced by prolonged P-wave dispersion and atrial electromechanical delay in psoriasis patients. Severe psoriasis further exacerbates atrial dysfunction, increasing susceptibility to AF. This review synthesizes existing epidemiological and biological data, highlighting the need for interdisciplinary management of psoriasis patients to mitigate cardiovascular risks. However, the reliance on observational studies limits definitive conclusions about causality. We emphasize the necessity for large-scale, multicenter research to validate these findings, investigate genetic predispositions, and evaluate lifestyle factors and AF burden. Future research should aim to delineate the pathophysiological link between psoriasis and AF. By examining the interplay of systemic inflammation, electrophysiological changes, and clinical outcomes, this review aims to advance understanding of the psoriasis-AF link and guide strategies for early detection, prevention, and management of AF in psoriasis patients. Comprehensive care integrating dermatology and cardiology is essential for improving patient outcomes.  \nKey Words: Psoriasis; Atrial fibrillation; Inflammation; Cytokines; Cardiovascular disease;  \n WJEM  [https://www.wjgnet.com](https://www.wjgnet.com) 1 December 20, 2025  Volume 15  Issue 4   \nMehta H et al. Psoriasis and AF: Key considerations  \nBiologic therapies  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Emergi","cbCaisnVriMDxBr6","https://ap.wps.com/l/cbCaisnVriMDxBr6","pdf",1179309,11,"English","# Abstract\n# Core Tip\n# Introduction","[{\"question\":\"What relationship between psoriasis and atrial fibrillation does the review address?\",\"answer\":\"The review examines an emerging connection between psoriasis and AF, highlighting shared inflammatory mechanisms and the clinical implications for AF risk in psoriatic patients.\"},{\"question\":\"Which inflammatory mediators are emphasized as common contributors?\",\"answer\":\"It emphasizes chronic systemic inflammation and specific cytokines, including interleukin (IL)-6, IL-17, and tumor necrosis factor-alpha, as central to psoriasis pathology and AF risk.\"},{\"question\":\"Why does the review call for further research?\",\"answer\":\"It notes reliance on observational studies, which limits definitive causal conclusions, and emphasizes the need for large-scale, multicenter work to validate mechanisms and identify genetic and lifestyle factors influencing AF burden.\"}]","Psoriasis and atrial fibrillation - Exploring the intersection | PDF",1790671724,28]