[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-331541-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-331541-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","proton-therapy-in-the-treatment-of-head-and-neck-cancers-review","Proton Therapy in The Treatment of Head And Neck Cancers - Review","","Head and neck cancers are a leading global malignancy with high mortality, commonly treated through radiotherapy and surgery. Proton therapy is presented as a radiotherapy approach designed for tumors located near anatomically sensitive structures where strict dose limits are required. Recent evidence indicates that reduced late adverse effects are linked to how much of the dose is delivered to organs at risk and the absolute/relative organ volumes exposed to specific dose levels. Overall, proton therapy offers a promising alternative by lowering radiation to healthy tissues outside the tumor while maintaining effectiveness.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/proton-therapy-in-the-treatment-of-head-and-neck-cancers-review/331541/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/proton-therapy-in-the-treatment-of-head-and-neck-cancers-review/331541.png","ImageObject",300,407,{"name":42,"@type":43},"Seraphina","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why is proton therapy considered important for head and neck cancers?","Question",{"text":63,"@type":64},"Proton therapy is designed for tumors near anatomically sensitive organs where radiation dose must be strictly limited. It aims to reduce late adverse effects in nearby critical tissues.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How do side effects relate to proton therapy exposure?",{"text":68,"@type":64},"The occurrence and severity of side effects depend on the relative and absolute volume of organs at risk receiving specific radiation doses.",{"name":70,"@type":61,"acceptedAnswer":71},"What physical advantage of proton therapy reduces exit dose compared with photons?",{"text":72,"@type":64},"Proton beams deposit most energy near the end of their path and lack an exit dose, leading to a dose rise to a peak and then a sharp fall rather than continued deposition through the body.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331541,1790907560,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":55,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":117},962075114101,"https://ap-avatar.wpscdn.com/avatar/e000253a75eb197efd?x-image-process=image/resize,m_fixed,w_180,h_180&k=1780044092746381165","Current Oncology Reports (2024) 26:1380–1387 [https://doi.org/10.1007/s1](https://doi.org/10.1007/s1) 1912-024-01592-9  \nProton Therapy in The Treatment of Head And Neck Cancers‑ Review  \nKamila Bała1 · Yana Samovich1 · Karolina Dorobisz1  \nAccepted: 29 July 2024 / Published online: 8 August 2024 © The Author(s) 2024  \nAbstract  \nPurpose of Review Head and neck cancers rank as the seventh most common cancer worldwide, nearly half of which result in death. The most common treatment methods for head and neck cancers include radiotherapy and surgery. Proton therapy has emerged in radiotherapy for cases where tumors are located near anatomically sensitive areas where the radiation dose must be strictly limited. The purpose of the work is to discuss the role of the proton therapy in the treatment in various types of cancer, and particularly head and neck tumors.  \nRecent Findings Proton therapy allows for the delivery of radiation doses to critical organs to be reduced, resulting in a decrease in the occurrence of late adverse effects on these organs. The occurrence of side effects caused by proton therapy depends on the relative and absolute volume of organs at risk receiving specific radiation doses.  \nSummary Proton therapy represents a promising alternative to conventional radiotherapy due to the reduced number of complications in healthy tissues by delivering a lower radiation dose outside the tumor area.  \nKeywords Proton Therapy · Proton Beam Therapy · Head and Neck Cancer · Cancer Proton Therapy · Toxicity  \nIntroduction  \nAccording to GLOBOCAN 2020, head and neck can‑ cers rank as the seventh most common cancer worldwide, accounting for over 900,000 new cases annually, nearly half of which result in death. Currently, the treatment strategies for head and neck cancers encompass various disciplines including surgery, radiotherapy, chemotherapy, and sup‑ portive care [1] . The most common treatment methods for head and neck cancers include radiotherapy, surgery, or a combination of both [2] . Due to distant metastases being less common in head and neck cancers compared to other malignancies, the primary determinant of patient survival is the local growth of the tumor, necessitating effective locore‑ gional control [2] .  \nThe concept of applying proton beams in clinical practice was pioneered by the American physicist Robert Wilson in 1946 [3]. The first clinical application, involving the removal of pituitary tumors in breast cancer patients, took place in  \nBerkeley, California in 1954. This invention led to proton therapy being administered to nearly 40,000 patients over half a century [2]. The unique physical properties of proton therapy allow for the delivery of higher radiation doses while simultaneously reducing the radiation dose to surrounding tissues, resulting in fewer complications [4] .  \nStudy Design  \nThe purpose of the work is to discuss the role of the pro‑ ton therapy in the treatment in various types of cancer, and particularly head and neck tumors. The literature search strategy was carried out using the PubMed base based on the keyword combination: Proton Therapy, Proton Beam Therapy, Head and Neck Cancer, Cancer Proton Therapy, Toxicity. The references of the publications of interest were also screened for relevant papers. There were no limitations in regard to the publication date.  \n* Kamila Bała[kamila.bala@wp.pl](kamila.bala@wp.pl)  \n1 Department of Otolaryngology, Head and Neck Surgery, Wroclaw Medical University, Borowska 213, 50‑556, Wrocław, Poland  \nProton Therapy  \nProton therapy has emerged in radiotherapy for cases where tumors are located near anatomically sensitive areas [5] . Examples include tumors at the base of the skull, spine or its vicinity close to the brainstem, cranial nerves, and/or optic structures, as well as other tumors such as hepatocellular carcinoma to maximize the preser‑ vation of non‑cancerous liver parenchyma or mediastinal lymphomas, which occupy a large area, and man","cbCaifc9FHh6LYWc","https://ap.wps.com/l/cbCaifc9FHh6LYWc","pdf",632313,"English","# Abstract\n# Introduction\n## Study Design\n# Proton Therapy\n## Bragg peak and SOBP concept\n## Patient populations and program experience","[{\"question\":\"Why is proton therapy considered important for head and neck cancers?\",\"answer\":\"Proton therapy is designed for tumors near anatomically sensitive organs where radiation dose must be strictly limited. It aims to reduce late adverse effects in nearby critical tissues.\"},{\"question\":\"How do side effects relate to proton therapy exposure?\",\"answer\":\"The occurrence and severity of side effects depend on the relative and absolute volume of organs at risk receiving specific radiation doses.\"},{\"question\":\"What physical advantage of proton therapy reduces exit dose compared with photons?\",\"answer\":\"Proton beams deposit most energy near the end of their path and lack an exit dose, leading to a dose rise to a peak and then a sharp fall rather than continued deposition through the body.\"}]","Proton Therapy in The Treatment of Head And Neck Cancers - Review | PDF",1789993815]