[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329933-105":59,"doc-detail-329933-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","protein-glycosylation-in-lung-cancer-from-a-mass-spectrometry-perspective","Protein glycosylation in lung cancer from a mass spectrometry perspective","","Lung cancer requires improved diagnostic and therapeutic options. Aberrant protein glycosylation is linked to the disease’s pathogenesis and progression, with distinct glycosylation patterns reported between healthy versus cancer tissues and among lung cancer subtypes. These differences suggest clinically relevant, previously underused diagnostic potential. Characterizing glycosylation changes can also reveal novel therapeutic targets and support personalized treatment strategies. Mass-spectrometry-based glycomics and glycoproteomics provide high-resolution characterization of molecular alterations.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/protein-glycosylation-in-lung-cancer-from-a-mass-spectrometry-perspective/329933/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/protein-glycosylation-in-lung-cancer-from-a-mass-spectrometry-perspective/329933.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is protein glycosylation important in lung cancer?","Question",{"text":112,"@type":113},"Aberrant protein glycosylation contributes to lung cancer pathogenesis and progression. Reported glycosylation-pattern differences between healthy and cancer samples support this role.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do mass spectrometry methods help study glycosylation in lung cancer?",{"text":117,"@type":113},"Mass-spectrometry-based glycomics and glycoproteomics enable in-depth characterization of protein glycosylation changes. This helps reveal molecular bases of lung cancer and supports biomarker research.",{"name":119,"@type":110,"acceptedAnswer":120},"What diagnostic and therapeutic potential do glycosylation changes offer?",{"text":121,"@type":113},"Differences in glycosylation patterns across samples and subtypes suggest diagnostic value. Understanding these changes may also support new therapeutic target discovery and personalized treatment strategies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329933,1790195063,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","DOI: 10.1002/mas.21882  \nREV I EW ARTICLE  \nProtein glycosylation in lung cancer from a mass spectrometry perspective  \nMirjam Balbisi1,2  | Simon Sugár1 | Lilla Turiák1   \n1MTA‐TTK Lendület (Momentum) Glycan Biomarker Research Group, HUN‐REN Research Centre for Natural Sciences, Budapest, Hungary 2Semmelweis University Doctoral School, Budapest, Hungary  \nCorrespondence  \nLilla Turiák, HUN‐REN Research Centre for Natural Sciences, Magyar tudósokkörútja 2., H‐1117 Budapest, Hungary. Email: [turiak.lilla@ttk.hu](turiak.lilla@ttk.hu)  \nFunding information  \nJános Bolyai Research Scholarship of the Hungarian Academy of Sciences; National Research, Development, and Innovation Fund of Hungary,  \nGrant/Award Numbers: 2018‐1.2.1‐NKP‐  \nAbstract  \nLung cancer is a severe disease for which better diagnostic and therapeutic approaches are urgently needed. Increasing evidence implies that aberrant protein glycosylation plays a crucial role in the pathogenesis and progression of lung cancer. Differences in glycosylation patterns have been previously observed between healthy and cancerous samples as well as between different lung cancer subtypes, which suggests untapped diagnostic potential. In addition, understanding the changes mediated by glycosylation may shed light on possible novel therapeutic targets and personalized treatment strategies for lung cancer patients. Mass spectrometry based glycomics and glycoproteomics have emerged as powerful tools for in‐depth characterization of changes in protein glycosylation, providing valuable insights into the molecular basis of lung cancer. This paper reviews the literature on the analysis of protein glycosylation in lung cancer using mass spectrometry, which is dominated by manuscripts published over the past 5 years. Studies analyzing N‐glycosylation,  \nAbbreviations: 2‐D DIGE, two‐dimensional difference gel electrophoresis; 2‐D PAGE, two‐dimensional polyacrylamide gel electrophoresis; 2‐DE, two‐dimensional gel electrophoresis; A1AG1, alpha‐1‐acid glycoprotein; A1BG, alpha‐1B‐glycoprotein; AC, adenocarcinoma; ACT, alpha‐1‐ antichymotrypsin; ALK, anaplastic lymphoma kinase; APCS, serum amyloid p component; Asn, asparagine; AUC, area under curve; AZGP1, zinc‐ alpha‐2‐glycoprotein; BAL, bronchoalveolar lavage; BLD, benign lung disease; C18, octadecyl bonded silica; C9, complement component C9; CE, capillary electrophoresis; CFB, complement factor B; CP, ceruloplasmin; CRP, C‐reactive protein; CS, chondroitin sulfate; DS, dermatan sulfate; DSIgG, disease‐specific immunoglobulin G; EGFR, epidermal growth factor receptor; ELISA, enzyme‐linked immunosorbent assay; ESI, electrospray ionization; EV, extracellular vesicle; FF, fresh‐frozen; FFPE, formalin‐fixed, paraffin‐embedded; FTICR, Fourier‐transform ion cyclotron resonance; Fuc, fucose; FUT, fucosyltransferase; Fyn, proto‐oncogene tyrosine‐protein kinase Fyn; GAG, glycosaminoglycan; Gal, galactose; GalNAc, N‐acetylgalactosamine; GlcNAc, N‐acetylglucosamine; GPI‐80, vascular noninflammatory molecule 2; HA, hyaluronan; HILIC, hydrophilic interaction chromatography; Hp, haptoglobin; HPLC, high‐performance liquid chromatography; HPX, hemopexin; HS, heparan sulfate; IGFBP3, insulin‐like growth factor‐binding protein 3; IgG, immunoglobulin G; IGHG3, immunoglobulin heavy constant gamma 3; ITGB3, integrin beta 3; iTRAQ, isobaric tags for relative and absolute quantification; KRAS, Kirsten rat sarcoma virus; LCC, large cell carcinoma; LFQ, label‐free quantification; LIT, linear ion trap; L‐PGDS, lipocalin‐type prostaglandin D synthase; LRG1, leucine‐rich alpha‐2‐glycoprotein; MALDI, matrix‐ assisted laser desorption/ionization; Man, mannose; MRM, multiple reaction monitoring; MS/MS, tandem mass spectrometry; MS, mass spectrometry; NBS, 2‐nitrobenzensulfenyl; NSCLC, non‐small cell lung cancer; PAGE, polyacrylamide gel electrophoresis; PD‐1, programmed cell death protein 1; PD‐L1, programmed cell death ligand 1; PEDF, pigment epithelial differentiation fac","cbCaicdUibKGIFRP","https://ap.wps.com/l/cbCaicdUibKGIFRP","pdf",1113435,21,"English","# Introduction\n## Abbreviations\n## Keywords\n## Funding and licensing","[{\"question\":\"Why is protein glycosylation important in lung cancer?\",\"answer\":\"Aberrant protein glycosylation contributes to lung cancer pathogenesis and progression. Reported glycosylation-pattern differences between healthy and cancer samples support this role.\"},{\"question\":\"How do mass spectrometry methods help study glycosylation in lung cancer?\",\"answer\":\"Mass-spectrometry-based glycomics and glycoproteomics enable in-depth characterization of protein glycosylation changes. This helps reveal molecular bases of lung cancer and supports biomarker research.\"},{\"question\":\"What diagnostic and therapeutic potential do glycosylation changes offer?\",\"answer\":\"Differences in glycosylation patterns across samples and subtypes suggest diagnostic value. Understanding these changes may also support new therapeutic target discovery and personalized treatment strategies.\"}]","Protein glycosylation in lung cancer from a mass spectrometry perspective | PDF",1789986202,53]