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Phellinus igniarius has reported therapeutic value, yet mechanisms remain unclear. The study evaluates therapeutic effects in model rats and focuses on gut microbiota and metabolite regulation. SH-P-1-1 lowers uric acid and creatinine, reduces xanthine oxidase activity, alleviates kidney damage and joint urate deposition, and shifts microbial abundance and metabolic pathways, including tryptophan metabolism.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/protective-effects-of-polysaccharide-sh-p-1-1-isolated-from-phellinus-igniarius-on-hyperuricemia-and-gout-via-intestinal-microecosystem-regulation/417590/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/protective-effects-of-polysaccharide-sh-p-1-1-isolated-from-phellinus-igniarius-on-hyperuricemia-and-gout-via-intestinal-microecosystem-regulation/417590.png","ImageObject",300,407,{"name":92,"@type":93},"Patrick","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",16,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What condition does SH-P-1-1 target in the study?","Question",{"text":113,"@type":114},"The study targets hyperuricemia (HUA) and gout, examining therapeutic effects in model rats.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does SH-P-1-1 affect uric acid and kidney-related outcomes?",{"text":118,"@type":114},"SH-P-1-1 significantly decreases uric acid and creatinine levels, reduces xanthine oxidase and adenosine deaminase activities, and alleviates kidney damage.",{"name":120,"@type":111,"acceptedAnswer":121},"What mechanism is proposed for SH-P-1-1’s beneficial effects?",{"text":122,"@type":114},"The beneficial effects are linked to regulation of the intestinal microecosystem, including changes in gut microbiota composition and differential metabolites involved in pathways such as tryptophan metabolism.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},417590,1790810861,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},549758146520,"https://ap-avatar.wpscdn.com/avatar/80002397d8c0411e94?_k=1775819394049821470","OPEN ACCESS  \nEDITED BY  \nBarbara E. Teixeira-Costa,  \nFluminense Federal University, Brazil  \nREVIEWED BY  \nLanzhou Li,  \nJilin Agricultural University, China Siyue Song,  \nZhejiang Academy of Traditional Chinese Medicine, China  \n*CORRESPONDENCE  \nZaizhong Ni  \n [nizaizhong@163.com](nizaizhong@163.com)[ ](nizaizhong@163.com)Anhui Chen  \n [chenah201@163.com](chenah201@163.com)  \n†These authors have contributed equally to this work  \nRECEIVED 02 October 2025  \nREVISED 23 November 2025  \nACCEPTED 03 December 2025  \nPUBLISHED 19 December 2025  \nCITATION  \nWang Y, Qian X, Chen L, Yang L, Zhang Z, Qu Z, Yang Y, Li Y, Ni Z, Shao Y and  \nChen A (2025) Protective effects of polysaccharide SH-P-1-1 isolated from Phellinus igniarius on hyperuricemia and gout via intestinal microecosystem regulation. Front. Nutr. 12:1717561 .  \ndoi: 10.3389/fnut.2025.1717561  \nCOPYRIGHT  \n© 2025 Wang, Qian, Chen, Yang, Zhang, Qu, Yang, Li, Ni, Shao and Chen. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nTYPE Original Research PUBLISHED 19 December 2025 DOI 10.3389/fnut.2025.1717561  \nProtective effects of polysaccharide SH-P-1-1 isolated from Phellinus igniarius on hyperuricemia and gout via intestinal microecosystem regulation  \nYanan Wang 1,2†, Xinyi Qian 1†, Lingzhi Chen3, Ling Yang 1, Zhenjiang Zhang4, Zhilong Qu4, Yuhan Yang 1, Yihao Li 1, Zaizhong Ni 1,2*, Ying Shao 1,2 and Anhui Chen 1,2*  \n1College of Food and Bioengineering, Xuzhou University of Technology, Xuzhou, Jiangsu, China, 2Jiangsu Key Construction Laboratory of Food Resource Development and Quality Safe, Xuzhou University of Technology, Xuzhou, Jiangsu, China, 3School of Biotechnology, Jiangnan University, Wuxi, Jiangsu, China, 4Anhui Yanhuang Biotechnology Co., Ltd., Hefei, Anhui, China  \nIntroduction: Although Phellinus igniarius has been shown to treat hyperuricemia (HUA) and gout, a self-inflammatory disease caused by purine metabolism disorders, the underlying mechanisms remain unclear. Polysaccharides are among the main components of P. igniarius with antiinflammatory and immunoregulatory properties.  \nMethods: Here, we examined the therapeutic effects of polysaccharide SH-P- 1-1 isolated from P. igniarius on HUA and gout, and explored the underlying mechanism, focusing on gut microbiota and metabolite regulation.  \nResults: SH-P-1-1 significantly decreased uric acid and creatinine levels, reduced xanthine oxidase and adenosine deaminase activities, alleviated kidney damage, and reduced urate deposition in joints in model rats. It increased the abundance of Blautia and Muribaculaceae but reduced that of the Lachnospiraceae_NK4A136_group, Lactobacillus, and Turicibacter. SH-P- 1-1 also significantly modulated the metabolic profile and was closely related to some metabolic pathways, such as tryptophan metabolism, relevant to HUA and gout. The beneficial activities of SH-P-1-1 correlated with gut microbiota composition and differential metabolites, including short-chain fatty acids. Discussion: Overall, this study demonstrates the potential of SH-P-1-1 as a natural supplement for preventing and managing HUA and gout.  \nKEYWORDS  \nPhellinus igniarius, polysaccharide, structural characterization, hyperuricemia, gout, intestinal microecosystem  \n1 Introduction  \nGout is an auto-inflammatory disorder induced by chronic HUA due to disturbance in purine metabolism ( 1). It manifests as a gradual deposition of uric acid (UA) salt crystals in joints and surrounding tissues, triggering an innate immune response while inducing stressful arthritis (2, 3). Patients with gout typically present wit","cbCairCCnKb6LOFB","https://ap.wps.com/l/cbCairCCnKb6LOFB","pdf",5477219,15,"English","# Introduction\n# Methods\n# Results\n# Discussion\n# Keywords","[{\"question\":\"What condition does SH-P-1-1 target in the study?\",\"answer\":\"The study targets hyperuricemia (HUA) and gout, examining therapeutic effects in model rats.\"},{\"question\":\"How does SH-P-1-1 affect uric acid and kidney-related outcomes?\",\"answer\":\"SH-P-1-1 significantly decreases uric acid and creatinine levels, reduces xanthine oxidase and adenosine deaminase activities, and alleviates kidney damage.\"},{\"question\":\"What mechanism is proposed for SH-P-1-1’s beneficial effects?\",\"answer\":\"The beneficial effects are linked to regulation of the intestinal microecosystem, including changes in gut microbiota composition and differential metabolites involved in pathways such as tryptophan metabolism.\"}]","Protective effects of polysaccharide SH-P-1-1 isolated from Phellinus igniarius on hyperuricemia and gout - via intestinal microecosystem regulation | PDF",1790609760,38]