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Risk factors include genetic predisposition, family history, race/ethnicity, and occupational influences such as diet, obesity, smoking, and transmitted diseases. The JAK/STAT pathway regulates cell growth, differentiation, immune responses, and apoptosis, and its dysregulation is linked to cancer and inflammation. This review addresses PC incidence and risk, the JAK/STAT3 pathway and inhibitors, and how flavonoids may affect this pathology.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prostate-cancer-jakstat3-dysregulation-and-flavonoids-is-there-a-possible-link/344664/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prostate-cancer-jakstat3-dysregulation-and-flavonoids-is-there-a-possible-link/344664.png","ImageObject",300,407,{"name":92,"@type":93},"Himbo","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What major biological role does the JAK/STAT3 pathway play in the body?","Question",{"text":112,"@type":113},"The JAK/STAT3 pathway regulates gene expression programs that control cell growth, differentiation, immune regulation, and apoptosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does STAT3 dysregulation relate to disease development?",{"text":117,"@type":113},"Dysregulated JAK/STAT3 signaling contributes to cancer progression and inflammation, and is also associated with conditions such as diabetes and neurodegenerative disorders.",{"name":119,"@type":110,"acceptedAnswer":120},"What do the review’s findings suggest about flavonoids in prostate cancer?",{"text":121,"@type":113},"Natural flavonoids may be developed as cancer-preventive and therapeutic agents, and experimental evidence indicates some flavonoids can inhibit prostate cancer development.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},344664,1790193034,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},687197100911,"https://ap-avatar.wpscdn.com/avatar/a000239b6f1da00475?x-image-process=image/resize,m_fixed,w_180,h_180&k=1785132997149421697","Review  \nProstate Cancer, JAK/STAT3 Dysregulation, and Flavonoids: Is There a Possible Link?  \nValentina Uivarosi 1, Daniela Miricescu 2,*, Ileana Adela Vacaroiu 3,*, Dan Arsenie Spinu 4,5, Constantin Stefani 6, Silviu Stanciu 7, Remus Iulian Nica 8,9, Iulia-Ioana Stanescu-Spinu 10, Silviu Constantin Badoiu 11,  \nSilvia Nica 12,13 and Viorel Jinga 14,15  \nAcademic Editor: Shafiq Khan  \nReceived: 14 December 2025  \nRevised: 7 January 2026  \nAccepted: 13 January 2026  \nPublished: 15 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of General and Inorganic Chemistry, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Str., 020956 Bucharest, Romania; valentina.uivarosi@umfcd.ro  \n2 Discipline of Biochemistry, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania  \n3 Department of Nephrology, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania  \n4 Department 3, Faculty of Medicine, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania; [arsenie.spinu@umfcd.ro](arsenie.spinu@umfcd.ro)  \n5 Urology Department,“Dr. Carol Davila” Central Military Emergency University Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania  \n6 Department I of Family Medicine and Clinical Base,“Dr. Carol Davila” Central Military Emergency University Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania; [constantin.stefani@umfcd.ro](constantin.stefani@umfcd.ro)  \n7 Department of Internal Medicine and Gastroenterology, Carol Davila University of Medicine and Pharmacy,“Dr. Carol Davila” Central Military Emergency University Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania; [silviu.stanciu@umfcd.ro](silviu.stanciu@umfcd.ro)  \n8 Discipline of General Surgery, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania; remus.nica@umfcd.ro  \n9 Surgery Department,“Dr. Carol Davila” Central Military Emergency University Hospital, 134 Calea Plevnei, 010825 Bucharest, Romania  \n10 Discipline of Physiology, Faculty of Dentistry, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania; [iulia.stanescu@umfcd.ro](iulia.stanescu@umfcd.ro)  \n11 Department of Anatomy and Embryology, Faculty of Midwifery and Nursing, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd., 050474 Bucharest, Romania; [silviu.badoiu@umfcd.ro](silviu.badoiu@umfcd.ro)  \n12 Department of Emergency and First Aid, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitarii Blvd., 050474 Bucharest, Romania; [silvia.nica@umfcd.ro](silvia.nica@umfcd.ro)  \n13 Emergency Discipline, University Hospital of Bucharest, Independence Str., 050094 Bucharest, Romania  \n14 Department of Urology, Carol Davila University of Medicine and Pharmacy, 8 Eroii Sanitari Blvd.,  \n050474 Bucharest, Romania; [viorel.jinga@umfcd.ro](viorel.jinga@umfcd.ro)  \n15 Romanian Academy, 125 Calea Victoriei, 010071 Bucharest, Romania  \n* Correspondence: [daniela.miricescu@umfcd.ro](daniela.miricescu@umfcd.ro) (D.M.); ileana.vacaroiu@umfcd.ro (I.A.V.)  \nAbstract  \nWorldwide, prostate cancer (PC) has a rising incidence and is the sixth leading cause of death globally, especially with increasing cases in developing countries. Risk factors for PC include genetic predisposition, family history, race/ethnicity, and various occupational factors like diet, obesity, smoking, and transmitted diseases. The Janus kinase (JAK)-signal transducer and activator of transcription (STAT) pathway can be activated by hormones, cytokines, and growth factors, and it plays a role in many vital biological processes ","cbCaieuOmtYYOkcO","https://ap.wps.com/l/cbCaieuOmtYYOkcO","pdf",1263723,23,"English","# Abstract\n# Keywords\n# JAK/STAT3 Pathway Overview","[{\"question\":\"What major biological role does the JAK/STAT3 pathway play in the body?\",\"answer\":\"The JAK/STAT3 pathway regulates gene expression programs that control cell growth, differentiation, immune regulation, and apoptosis.\"},{\"question\":\"How does STAT3 dysregulation relate to disease development?\",\"answer\":\"Dysregulated JAK/STAT3 signaling contributes to cancer progression and inflammation, and is also associated with conditions such as diabetes and neurodegenerative disorders.\"},{\"question\":\"What do the review’s findings suggest about flavonoids in prostate cancer?\",\"answer\":\"Natural flavonoids may be developed as cancer-preventive and therapeutic agents, and experimental evidence indicates some flavonoids can inhibit prostate cancer development.\"}]","Prostate Cancer, JAK/STAT3 Dysregulation, and Flavonoids: Is There a Possible Link? | PDF",1790054790,58]