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A 6-month randomized controlled trial assessed whether n-3 PUFAs monotherapy reduces recurrent MDD. Sixty remitted patients were assigned to n-3 (n=30) or placebo (n=30). HRSD recurrence was defined by HRSD score >20. Results showed no monthly HRSD differences, but omega-3 monotherapy lowered recurrence at month 6 and improved survival-based recurrence prevention, with higher EPA levels but no DHA difference.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prophylactic-effect-of-omega-3-polyunsaturated-fatty-acids-monotherapy-in-preventing-recurrent-major-depressive-disorder-a-randomized-controlled-trial/464358/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prophylactic-effect-of-omega-3-polyunsaturated-fatty-acids-monotherapy-in-preventing-recurrent-major-depressive-disorder-a-randomized-controlled-trial/464358.png","ImageObject",300,407,{"name":92,"@type":93},"moss~","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study’s primary objective?","Question",{"text":112,"@type":113},"To assess the prophylactic effect of n-3 PUFAs monotherapy in preventing recurrence of major depressive disorder.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the trial designed and how were participants assigned?",{"text":117,"@type":113},"A 6-month randomized controlled trial assigned 60 remitted MDD patients to an n-3 group (n=30) or placebo (n=30).",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about MDD recurrence and depressive severity?",{"text":121,"@type":113},"There was no significant monthly difference in HRSD scores, but omega-3 monotherapy reduced recurrence at month 6 and showed superiority to placebo in survival analysis. EPA levels increased with omega-3, while DHA did not differ.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},464358,1790811373,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},962090895452,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","BioMedicine  \n\n| Volume 15  Issue 4 | Article 5 |\n| --- | --- |\n| 2025\u003Cbr>Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Monotherapy in Preventing Recurrent Major Depressive Disorder: A Randomized Controlled Trial\u003Cbr>Follow this and additional works at: [https://www.biomedicinej.com/biomedicine](https://www.biomedicinej.com/biomedicine)\u003Cbr> Part of the Life Sciences Commons, and the Medical Sciences Commons\u003Cbr>\u003Cbr>This work is licensed under a Creative Commons Attribution 4.0 License. |  |\n\nRecommended Citation  \nMalau, Ikbal Andrian; Chang, Cheng-Ho; Chen, Wei-Jen; Liu, Wen-Chun; Zailani, Halliru; Liao, Hsien-Feng; Chang, Jane Pei-Chen; Chiu, Wei-Che; and Su, Kuan-Pin (2025) \"Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Monotherapy in Preventing Recurrent Major Depressive Disorder: A Randomized Controlled Trial,\" BioMedicine: Vol. 15 : Iss. 4 , Article 5.  \nDOI: 10.37796/2211-8039 .1667  \nThis Original Article is brought to you for free and open access by BioMedicine. It has been accepted for inclusion in BioMedicine by an authorized editor of BioMedicine.  \nORIGINAL ARTICLE  \nProphylactic effect of omega-3 polyunsaturated fatty acids monotherapy in preventing recurrent major depressive disorder: A randomized controlled trial  \nIkbal Andrian Malau a,b,1, Cheng-Ho Chang c,1, Wei-Jen Chen d,1, Wen-Chun Liu e, Halliru Zailani a,f,g, Hsien-Feng Liao h, Jane Pei-Chen Chang a,i,j, Wei-Che Chiu k,l,*, Kuan-Pin Su d,i,m,n,**  \na Mind-Body Interface Research Center (MBI-Lab) and Department of Psychiatry, China Medical University Hospital, Taichung, Taiwan b Graduate Institute of Biomedical Sciences, College of Medicine, China Medical University, Taichung, Taiwan  \nc Department of Psychiatry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan d An Nan Hospital, China Medical University,(CMU) Tainan, Taiwan  \ne Department of Nursing, National Tainan Junior College of Nursing, Tainan, Taiwan f Graduate Institute of Nutrition, China Medical University, Taichung, Taiwan g Department of Biochemistry, Ahmadu Bello University, Zaria, Nigeria  \nh Jenteh Junior College of Medicine, Nursing and Management, Miaoli, Taiwan i College of Medicine, China Medical University,(CMU) Taichung, Taiwan  \nj Child and Adolescent Psychiatry Division, China Medical University Hospital, Taichung, Taiwan k Department of Psychiatry, Cathay General Hospital, Taipei, Taiwan  \nl School of Medicine, Fu Jen Catholic University, Taipei, Taiwan  \nm Mind-Body Interface Research Center (MBI Lab & Care), CMU Hospital, Taichung, Taiwan n Office of Research and Development, Asia University, Taichung, Taiwan  \nAbstract  \nBackground: Omega-3 polyunsaturated fatty acids (n-3 PUFAs) have demonstrated efficacy as adjunctive treatment for MDD. In fact, fewer studies assessed the prophylactic properties of n-3 PUFAs as monotherapy on the recurrence of MDD.  \nAims: This study aimed to assess the prophylactic effect of n-3 PUFAs monotherapy against recurrent MDD.  \nMethods: We conducted a 6-month randomized controlled trial to assess the prophylactic effect of n-3 in preventing recurrent MDD. We assigned 60 remitted MDD patients to the n-3 group (n ¼ 30) and placebo (n ¼ 30). Furthermore, we assessed the difference in depression severity and MDD recurrence based on the 21-item Hamilton Rating Scale for Depression (HRSD) at months 1, 2, 3, 4, and 6 between groups. The recurrent event of MDD was defined as an HRSD score >20. Furthermore, biochemical parameters in plasma were assessed as the secondary outcomes.  \nResults: There was no significant difference in the HRSD score between the n-3 group and placebo each month (pvalue >0.05). However, our findings have implicated that omega-3 monotherapy for MDD contributed to a lower recurrence rate compared to the placebo group at month 6 (p-value ¼ 0.035). Omega-3 supplementation was superior to placebo to preventing recurrent MDD analyzed using KaplaneMeier survival analysis over a 6-month study period (pvalue ¼ 0.04","cbCaibAI3080HxLg","https://ap.wps.com/l/cbCaibAI3080HxLg","pdf",488835,11,"English","# Abstract\n## Background and Aims\n## Methods\n## Results and Conclusion\n# Introduction","[{\"question\":\"What was the study’s primary objective?\",\"answer\":\"To assess the prophylactic effect of n-3 PUFAs monotherapy in preventing recurrence of major depressive disorder.\"},{\"question\":\"How was the trial designed and how were participants assigned?\",\"answer\":\"A 6-month randomized controlled trial assigned 60 remitted MDD patients to an n-3 group (n=30) or placebo (n=30).\"},{\"question\":\"What did the study find about MDD recurrence and depressive severity?\",\"answer\":\"There was no significant monthly difference in HRSD scores, but omega-3 monotherapy reduced recurrence at month 6 and showed superiority to placebo in survival analysis. EPA levels increased with omega-3, while DHA did not differ.\"}]","Prophylactic Effect of Omega-3 Polyunsaturated Fatty Acids Monotherapy in Preventing Recurrent Major Depressive Disorder - A Randomized Controlled Trial | PDF",1790768078,28]