[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330215-105":59,"doc-detail-330215-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","promising-dawn-in-tumor-microenvironment-therapy-engineering-oral-bacteria","Promising dawn in tumor microenvironment therapy: engineering oral bacteria","","Cancer remains a leading global cause of death despite improvements in prevention, detection, and treatment. The review examines how oral microbes and engineered bacteria may influence tumor occurrence and progression through mechanisms within the tumor microenvironment. Engineered oral flora are discussed as enabling directed genetic reprogramming, selective functional reorganization, and precise therapeutic control, with favorable biosafety compared with endotoxin-producing typical engineered bacteria. Literature is searched in PubMed and synthesized to consider oral-bacteria engineering as a cancer therapy approach, offering insights for prevention and treatment strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/promising-dawn-in-tumor-microenvironment-therapy-engineering-oral-bacteria/330215/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/promising-dawn-in-tumor-microenvironment-therapy-engineering-oral-bacteria/330215.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main focus of the review article?","Question",{"text":112,"@type":113},"The review focuses on engineered oral bacteria and how they may be used to influence the tumor microenvironment for cancer therapy, summarizing mechanisms and related literature.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why are oral microbes considered promising for engineered cancer therapies?",{"text":117,"@type":113},"Oral flora are described as having favorable biosafety characteristics compared with endotoxins from typical genetically modified bacteria, while engineered strains can be programmed for targeted functions.",{"name":119,"@type":110,"acceptedAnswer":120},"How does the article describe the limitations of current cancer treatments and the need for targeted approaches?",{"text":121,"@type":113},"It highlights drawbacks of surgery, chemotherapy, and radiotherapy, including recurrence, toxicity to normal tissues, limited effectiveness in deep tumors, and risks such as immune system suppression and drug resistance. This motivates development of safe, targeted therapies.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330215,1790713562,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","International Journal of Oral Science [www.nature.com/ijos](www.nature.com/ijos)  \nREVIEW ARTICLE OPEN  \nPromising dawn in tumor microenvironment therapy: engineering oral bacteria  \nZifei Wang 1, Wansu Sun2, Ruixue Hua 1, Yuanyin Wang 1, Yang Li 3 ✉ and Hengguo Zhang 1 ✉  \n\n|  | Despite decades of research, cancer continues to be a major global health concern. The human mouth appears to be a multiplicity of local environments communicating with other organs and causing diseases via microbes. Nowadays, the role of oral microbes in the development and progression of cancer has received increasing scrutiny. At the same time, bioengineering technology and nanotechnology is growing rapidly, in which the physiological activities of natural bacteria are modified to improve the therapeutic efficiency of cancers. These engineered bacteria were transformed to achieve directed genetic reprogramming, selective functional reorganization and precise control. In contrast to endotoxins produced by typical genetically modified bacteria, oral flora exhibits favorable biosafety characteristics. To outline the current cognitions upon oral microbes, engineered microbes and human cancers, related literatures were searched and reviewed based on the PubMed database. We focused on a number of oral microbes and related mechanisms associated with the tumor microenvironment, which involve in cancer occurrence and development. Whether engineering oral bacteria can be a possible application of cancer therapy is worth consideration. A deeper understanding of the relationship between engineered oral bacteria and cancer therapy may enhance our knowledge of tumor pathogenesis thus |  |\n| --- | --- | --- |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n|  |  |  |\n| providing new insights and strategies for cancer prevention and treatment. |  |  |\n|  | International Journal of Oral Science (2024)16:24 ; [https://doi.org/10.1038/s41368-024-00282-3](https://doi.org/10.1038/s41368-024-00282-3) |  |\n|  |  |  |\n\nINTRODUCTION  \nCancer remains a major global health concern, and despite recent advances in prevention, detection, and treatment, it remains a leading cause of death worldwide, accounting for an estimated 10 million deaths in 2020 .1 Studies have shown that the occurrence of many cancers can be attributed to random DNA mutations in highly dividing cell populations.2 The classic cancer-associated environmental risk factors are tobacco smoking, alcohol consumption, high body mass index (BMI), and exposure to ultraviolet radiation.3,4 Traditional cancer treatment methods, including surgery, chemotherapy, and radiation therapy, achieved certain therapeutic effects. However, these methods go along with significant limitations.5 For instance, surgical operation might end up with a high recurrence rate and poor prognosis upon cancer spread and growth, which results from the modulation of tumor dormancy, inflammatory response, and postoperative infection.6–8 Chemotherapy and radiotherapy exert notable influences on the immune system’s status, exhibiting pronounced toxicity toward normal tissue cells. Moreover, their efficacy in addressing deeply-rooted tumor tissues is somewhat restricted, thus presenting inherent challenges. Additionally, there exists a potential risk of developing drug resistance over time.5,9 As a result, these cytotoxic therapies often eliminate cancer cells at the expense of damaging normal tissues, resulting in unacceptable toxicity. Therefore, the objective of cancer treatment is to selectively eradicate tumors while minimizing harm to healthy cells. To achieve this, further research endeavors are required to develop effective targeted cancer treatment methods. In recent years, there has been significant progress in the field of  \nimmunotherapy, which has revolutionized traditional approaches to cancer treatment by shifting the focus from directly killing tumors to activating the host’s immune system.","cbCaiqyx5m9krbeS","https://ap.wps.com/l/cbCaiqyx5m9krbeS","pdf",2518466,17,"English","# INTRODUCTION\n# REVIEW ARTICLE","[{\"question\":\"What is the main focus of the review article?\",\"answer\":\"The review focuses on engineered oral bacteria and how they may be used to influence the tumor microenvironment for cancer therapy, summarizing mechanisms and related literature.\"},{\"question\":\"Why are oral microbes considered promising for engineered cancer therapies?\",\"answer\":\"Oral flora are described as having favorable biosafety characteristics compared with endotoxins from typical genetically modified bacteria, while engineered strains can be programmed for targeted functions.\"},{\"question\":\"How does the article describe the limitations of current cancer treatments and the need for targeted approaches?\",\"answer\":\"It highlights drawbacks of surgery, chemotherapy, and radiotherapy, including recurrence, toxicity to normal tissues, limited effectiveness in deep tumors, and risks such as immune system suppression and drug resistance. This motivates development of safe, targeted therapies.\"}]","Promising dawn in tumor microenvironment therapy: engineering oral bacteria | PDF",1789987765,43]