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Primary outcome was overall survival, with secondary endpoints including disease-free survival, surgical and pathologic outcomes, and postoperative complications. Multivariable Cox and logistic regression adjusted for key confounders including clinical stage, comorbidity, weight loss, and performance status. Results show no negative survival effect overall, but increased postoperative respiratory complications in the prolonged TTS group.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/prolonged-time-to-surgery-in-patients-with-residual-disease-after-neoadjuvant-chemoradiotherapy-for-esophageal-cancer/468113/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/prolonged-time-to-surgery-in-patients-with-residual-disease-after-neoadjuvant-chemoradiotherapy-for-esophageal-cancer/468113.png","ImageObject",300,407,{"name":42,"@type":43},"Aria","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What question does the study address about time to surgery?","Question",{"text":63,"@type":64},"Whether a prolonged time to surgery after nCRT negatively affects survival, pathologic outcome, or postoperative complications in patients with histologically confirmed residual disease.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were patients grouped for analysis?",{"text":68,"@type":64},"Patients with biopsy-proven residual disease 6 weeks after nCRT who underwent surgery were categorized as TTS > 12 weeks versus TTS ≤ 12 weeks.",{"name":70,"@type":61,"acceptedAnswer":71},"What were the main findings regarding survival and complications?",{"text":72,"@type":64},"Prolonged TTS was associated with better overall and disease-free survival in the reported analyses, while postoperative respiratory complications were more frequent. Other outcomes were comparable between groups.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},468113,1790955064,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":115,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Prolonged Time to Surgery in Patients With Residual Disease After Neoadjuvant Chemoradiotherapy for Esophageal  \nCancer  \nHidde C. G. Overtoom, BSc,✉ Ben M. Eyck, MD, PhD,  \nBerend J. van der Wilk, MD, PhD, Bo J. Noordman, MD, PhD,  \nPieter C. van der Sluis, MD, PhD, Bas P.L. Wijnhoven, MD, PhD, J. Jan B. van Lanschot, MD, PhD, Sjoerd M. Lagarde, MD, PhD, and on behalf of the SANO study group*  \nObjective: To investigate whether prolonged time to surgery negatively affects survival, pathologic outcome, or postoperative complications inpatients with histologically proven residual disease after neoadjuvant chemoradiotherapy (nCRT) for locally advanced esophageal cancer.  \nBackground: Historically, the standard time to surgery (TTS) has been 6 to 8 weeks after completion of nCRT. The effect of prolonged TTS is gaining interest, with contradicting results on survival and surgical morbidity. It can be hypothesized that, in patients with residual disease 6 weeks after completion of nCRT, prolonged TTS might be associated with worse survival and higher morbidity.  \nMethods: Patients with locally advanced esophageal cancer who had biopsy-proven residual disease 6 weeks after nCRT and underwent surgery, were categorized according to interval to surgery (TTS > 12w vs TTS≤ 12w) . The primary outcome of this study was overall survival. Secondary outcomes were disease-free survival, surgical outcomes, pathologic outcomes, and postoperative complications. Multivariable Cox regression was used for comparing survival and logistic regression for other outcomes, adjusted for the confounders age, cT, cN, Charlson comorbidity index, weight loss during nCRT, and WHO performance score after completion of nCRT.  \nResults: Forty patients were included for TTS > 12w and 127 for TTS≤ 12w. TTS > 12w was associated with better overall survival [adjusted hazard ratio (aHR) 0 .46, 95% CI: 0 .24–0.90], and diseasefree survival (aHR 0.48, 95% CI: 0.24–0.94), but also with more postoperative respiratory complications (aOR 3.66, 95% CI: 1.52–9. 59) . Other outcomes were comparable between both groups.  \nConclusions: Prolonged TTS in patients with histologically proven residual disease after completion of nCRT for esophageal cancer did not have a negative effect on overall and disease-free survival, but patients did have a higher risk for postoperative respiratory complications.  \nKey Words: esophageal cancer, neoadjuvant chemoradiotherapy,  \nprolonged time to surgery, residual disease (Ann Surg 2026;283:268–276)  \nFrom the Department of Surgery, Erasmus MC Cancer Institute, Erasmus University Medical Center, Rotterdam, The Netherlands.  \n✉ [h.overtoom@erasmusmc.nl](h.overtoom@erasmusmc.nl).  \nThe authors report no conflicts of interest.  \nSupplemental Digital Content is available for this article. Direct URL citations are provided in the HTML and PDF versions of this article on the journal’s website, [www.annalsofsurgery.com](www.annalsofsurgery.com).  \nCopyright © 2024 The Author(s) . Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution License 4 .0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nDOI: 10.1097/SLA.0000000000006488  \n[268](268 | www.annalsofsurgery.com)[ |](268 | www.annalsofsurgery.com)[ www.annalsofsurgery.com](268 | www.annalsofsurgery.com)  \nI n many countries, the standard treatment of locally  \nadvanced esophageal cancer (LAEC) is neoadjuvant chemoradiotherapy (nCRT) followed by esophagectomy. 1,2 Historically, the standard time to surgery (TTS) has been 6 to 8 weeks after completion of nCRT. Since the first publication on this subject by Kim et al,3 the effect of prolonged TTS for LAEC is gaining interest, with contradicting resultson survival and surgical morbidity.4–7  \nTo improve health-related quality of life, organ-sparing strategies are gaining increasing attention for patients wi","cbCaivSBqf8VJxYH","https://ap.wps.com/l/cbCaivSBqf8VJxYH","pdf",478338,"English","# Objective\n# Background\n# Methods\n## Study design and patients\n# Results\n# Conclusions","[{\"question\":\"What question does the study address about time to surgery?\",\"answer\":\"Whether a prolonged time to surgery after nCRT negatively affects survival, pathologic outcome, or postoperative complications in patients with histologically confirmed residual disease.\"},{\"question\":\"How were patients grouped for analysis?\",\"answer\":\"Patients with biopsy-proven residual disease 6 weeks after nCRT who underwent surgery were categorized as TTS \\u003e 12 weeks versus TTS ≤ 12 weeks.\"},{\"question\":\"What were the main findings regarding survival and complications?\",\"answer\":\"Prolonged TTS was associated with better overall and disease-free survival in the reported analyses, while postoperative respiratory complications were more frequent. Other outcomes were comparable between groups.\"}]","Prolonged Time to Surgery in Patients With Residual Disease After Neoadjuvant Chemoradiotherapy for Esophageal Cancer | PDF",1790773769,23]