[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331498-105":59,"doc-detail-331498-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","progress-in-application-of-nanomedicines-for-enhancing-cancer-sono-immunotherapy-review","Progress in application of nanomedicines for enhancing cancersono-immunotherapy - Review","","Cancer immunotherapy shows major promise by boosting antitumor immunity and reducing immune escape, yet clinical use remains constrained by low response rates and immune-related adverse effects. Ultrasound can reshape the tumor immune microenvironment, improve the efficacy of other anticancer treatments, and increase tumor sensitivity to immunotherapy. Nanomedicines further support immunological effects and strengthen ultrasound action, motivating design of effective nanomedicines to enhance sono-immunotherapy. This review discusses ultrasound modalities, parameters, mechanisms, and recent nanomedicine advances, concluding with opportunities and challenges.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/progress-in-application-of-nanomedicines-for-enhancing-cancer-sono-immunotherapy-review/331498/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/progress-in-application-of-nanomedicines-for-enhancing-cancer-sono-immunotherapy-review/331498.png","ImageObject",300,407,{"name":92,"@type":93},"Skyler","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is cancer immunotherapy potentially effective but still limited clinically?","Question",{"text":112,"@type":113},"It can enhance immune activity and reduce immune escape, but its clinical applicability is constrained by low response rates and immune-related side effects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does ultrasound contribute to improving cancer immunotherapy outcomes?",{"text":117,"@type":113},"Ultrasound can alter the tumor immune microenvironment, enhance other antitumor therapies, and make tumors more sensitive to immunotherapy through multiple mechanisms.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the role of nanomedicines in sono-immunotherapy?",{"text":121,"@type":113},"Nanomedicines are expected to improve immunological effects and strengthen ultrasound efficacy, and current progress focuses on synergistic enhancement of sono-immunotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331498,1790032901,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":46,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":31,"preview_page_count":4},2336464648746,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Ultrasonics Sonochemistry 111 (2024) 107105  \nContents lists available at ScienceDirect  \nUltrasonics Sonochemistry  \njournal [homepage:](homepage: www.elsevier.com/locate/ultson)[ www.elsevier.com/locate/ultson](homepage: www.elsevier.com/locate/ultson)  \n| Review\u003Cbr>Progress in application of nanomedicines for enhancing cancersono-immunotherapy |  |  | |\n| --- | --- | --- | --- |\n| Hongxin Zhao , Fangxue Du , Xi Xiang , Yuanjiao Tang , Ziyan Feng , Ziyao Wang , Xiao Rong\u003Cbr>*\u003Cbr>Li Qiu\u003Cbr>Department of Ultrasound, West China Hospital, Sichuan University, Chengdu 610041, China |  |  | *\u003Cbr>, |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords:\u003Cbr>Nanomedicines\u003Cbr>Sono-immunotherapy\u003Cbr>Ultrasound-mediated micro-/nanobubble destruction\u003Cbr>Sonodynamic therapy |  | Cancer immunotherapy has significant potential as a cancer treatment since it boosts the immune system and prevents immune escape to get rid of or fight cancers. However, its clinical applicability is still limited because of the low response rate and immune-related side effects. Recently ultrasound has been shown to alter the tumor immune microenvironment, enhance the effectiveness of other antitumor therapies, and cause tumors to become more sensitive to immunotherapy, thus providing new insights into cancer treatment. Nanomedicines are also anticipated to have a positive impact on improving the immunological effects and enhancing ultrasound effect for cancer therapy. Therefore, designing effective nanomedicines enhanced ultrasound effect for augmenting sono-immunotherapy has been a pivot on anticancer therapy. In this review, the immunological impacts of various ultrasound therapeutic modalities, ultrasound parameters, and their underlying mechanisms are discussed. Moreover, we highlight the recent progress of nanomedicines synergistically enhancing sonoimmunotherapy. Finally, we put forward opportunities and challenges on sono-immunotherapy. |  |\n\n1. Introduction  \nThe patient’s own cells multiply uncontrollably and harmfully, which is what causes cancer. Since the immune system views cancerous cells as “self,” it generally mounts a feeble defense against them. Furthermore, the tumor microenvironment often inhibits the immune response in cancer tissues through the emergence of receptors on cancer cells and the release of various immune-suppressive chemicals. Surgery, radiation therapy, and chemotherapy are examples of conventional standard cancer treatment regimens that are not effective in combating cancer and have a number of unavoidable side effects, such as weakened immune systems, bad drug reactions, high costs, and patient intolerance [1,2]. It is crucial to explore alternative, efficient therapeutic methods with minimal toxicity and high precision for the eradication of malignant tumors, especially their metastases, and to prevent their recurrence. Numerous studies on the complex relationships between malignancies and the immune systems have been conducted recently, and immunotherapy has demonstrated great promise during the therapies of certain patients with metastatic or advanced cancers[3]. A promising approach to treating cancer is immunotherapy, which includes adoptive T-cell therapy, immune checkpoint blockade (ICB)  \ntherapy, and vaccines for cancer[4,5]. In contrast to several conventional treatment approaches that target tumor cells directly, immunotherapy treats malignancies by stimulating the body’s natural defense system and activating immune cells[6]. Because immunotherapy creates long-term immunological memory, it is able to destroy not just localized cancers but also distant metastatic tumors and potentially prevent the return of tumors[7,8]. Cellular immunity and humoral immunity are components of human-specific immunity, and cellular immunity is primarily responsible for anti-cancer immunity. Dendritic cells (DCs), the most skilled antigen processing cells (APCs), are able to identify and phagocytize certain antigenic chemicals re","cbCaipiGvQgkl6Ib","https://ap.wps.com/l/cbCaipiGvQgkl6Ib","pdf",26886880,"English","# Introduction\n## Cancer and immune evasion\n## Limits of conventional therapies\n## Cancer immunotherapy overview\n## Role of ultrasound in cancer treatment\n## Ultrasound mechanisms and immunotherapy enhancement","[{\"question\":\"Why is cancer immunotherapy potentially effective but still limited clinically?\",\"answer\":\"It can enhance immune activity and reduce immune escape, but its clinical applicability is constrained by low response rates and immune-related side effects.\"},{\"question\":\"How does ultrasound contribute to improving cancer immunotherapy outcomes?\",\"answer\":\"Ultrasound can alter the tumor immune microenvironment, enhance other antitumor therapies, and make tumors more sensitive to immunotherapy through multiple mechanisms.\"},{\"question\":\"What is the role of nanomedicines in sono-immunotherapy?\",\"answer\":\"Nanomedicines are expected to improve immunological effects and strengthen ultrasound efficacy, and current progress focuses on synergistic enhancement of sono-immunotherapy.\"}]","Progress in application of nanomedicines for enhancing cancersono-immunotherapy - Review | PDF",1789993595]