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Material and Methods: Evidence was searched in Embase, PubMed, Web of Science, and Scopus for studies reporting overall survival (OS) or disease-free survival (DFS) using SII or SIRI, up to 25 May 2024. Results: Seventeen studies met criteria; high SII and high SIRI predicted worse OS, and high SII also predicted worse DFS. Conclusions: Despite evidence limitations, SII and SIRI can predict oral cancer prognosis.",{"@graph":69,"@context":115},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-value-of-systemic-immune-inflammation-index-and-systemic-inflammation-response-index-for-oral-cancers-a-systematic-review-and-meta-analysis/332777/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-value-of-systemic-immune-inflammation-index-and-systemic-inflammation-response-index-for-oral-cancers-a-systematic-review-and-meta-analysis/332777.png","ImageObject",300,407,{"name":92,"@type":93},"Quinn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109],{"name":110,"@type":111,"acceptedAnswer":112},"Were subgroup analyses consistent across patient and study characteristics?","Question",{"text":113,"@type":114},"Subgroup analyses by location, cancer type, sample size, treatment, cut-off, cut-off determination methods, analysis method, and study quality showed mixed results.","Answer","https://schema.org",{"og:url":83,"og:type":117,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":119,"canonical":83},"index,follow",{"doc_id":121,"site_id":62},332777,1790190476,{"code":4,"msg":5,"data":124},{"doc_id":121,"user_id":125,"nickname":92,"user_avatar":126,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":127,"file_id":128,"file_url":129,"file_type":130,"file_size":131,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":132,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":133,"faqs":134,"seo_title":135,"seo_description":67,"update_tm":136,"read_time":137,"preview_page_count":4},962075114765,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29 (6):e822-31. Systemic immune-inflammation index and systemic inflammation response index  \nJournal section: Oral Medicine and Pathology doi:10.4317/medoral.26779  \nPublication Types: Review  \nPrognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis  \nShaowei Yang 1, Chenyan Fei 1  \n1 Department of Stomatology, The second affiliated hospital of Jiaxing university, Jiaxing City, Zhejiang Province, China  \nCorrespondence:  \nDepartment of Stomatology  \nThe second affiliated hospital of Jiaxing university 1518 Huancheng North Road, Jianshe Street  \nNanhu District, Jiaxing City, Zhejiang Province, China [Callit9596@163.com](Callit9596@163.com)  \n[Received: 26/06/2024](Received: 26/06/2024)  \n[Accepted: 16/09/2024](Accepted: 16/09/2024)  \nYang S, Fei C. Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers: A systematic review and meta-analysis. Med Oral Patol Oral Cir Bucal. 2024 Nov 1;29 (6):e822-31.  \nArticle Number:26779 [http://www.medicinaoral.com/](http://www.medicinaoral.com/)  \n© Medicina Oral S. L. C.I.F. B 96689336-pISSN 1698-4447-eISSN: 1698-6946  \neMail: [medicina@medicinaoral.com](medicina@medicinaoral.com)  \nIndexed in:  \nScience Citation Index Expanded  \nJournal Citation Reports  \nIndex Medicus, MEDLINE, PubMed Scopus, Embase and Emcare Indice Médico Español  \nAbstract  \nBackground: The systemic immune-inflammation index (SII) and systemic inflammation response index (SIRI) are commonly used prognostic indicators for a variety of cancers. However, their utility in oral cancers is unknown. We systematically examined evidence on the ability of SII and SIRI to predict overall survival (OS) and disease-free survival (DFS) after oral cancers.  \nMaterial and Methods: Embase, PubMed, Web of Science, and Scopus were searched for oral cancer studies reporting OS or DFS based on SII or SIRI. Articles published up to 25th May 2024 were included.  \nResults: 17 studies were eligible (14 on SII and 3 on SIRI). Pretreatment high SII scores were found to be significantly linked with poor OS (HR: 1.62 95% 1.26, 2.08 I2=88%) and DFS (HR: 1.62 95% 1.25, 2.27 I2=86%) after oral cancer. Similarly, high SIRI was associated with worse OS in oral cancer patients (HR: 1.60 95% 1.31, 1.94 I2=0%). All results were unchanged on sensitivity analysis. Subgroup analysis based on location, cancer type, sample size, treatment, cut-off, methods of determining cut-off, analysis method, and study quality showed mixed results.  \nConclusions: Acknowledging the limitations of current evidence, it seems that both SII and SIRI can predict the prognosis of oral cancers. High SII and SIRI are both associated with worse OS while high SII also predicts worse DFS.  \nKey words: Oral carcinoma, inflammation, survival, prognosis.  \nIntroduction  \nOral cancer is one of the commonest malignancies of the head and neck and includes cancer of the lips and oral cavity (tongue, gingiva, floor of the mouth, palate, and other parts of the mouth). It is the 13th most diagnosed cancer worldwide leading to about 377,713 new cases and 177,757 deaths in 2020 alone (1). Significant heterogeneity exists in the distribution of oral cancer with the highest number of cases diagnosed in South-  \neast Asia and India alone accounting for about 1/3rd of the total global burden of oral cancer (2). The symptoms and the treatment of oral cancer have a major effect on apatient's quality of life affecting both cosmetic appearance and psychological well-being (3). Prognosis remains poor and 5-year survival in developed countries is about 64%(4). In developing countries which have a major share of cases, survival dips further and is only about 50% after 5-years (5). Considering such a poor  \nprognosis, there is a need for obtaining high-quality predictive markers that can accurately assess the progno","cbCaidPcvxcHaBmp","https://ap.wps.com/l/cbCaidPcvxcHaBmp","pdf",2432709,"English","# Abstract\n## Background\n## Material and Methods\n## Results\n## Conclusions\n# Introduction","[{\"question\":\"Were subgroup analyses consistent across patient and study characteristics?\",\"answer\":\"Subgroup analyses by location, cancer type, sample size, treatment, cut-off, cut-off determination methods, analysis method, and study quality showed mixed results.\"}]","Prognostic value of systemic immune-inflammation index and systemic inflammation response index for oral cancers - A systematic review and meta-analysis | PDF",1789999481,25]