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A total of 259 patients were enrolled and stratified by high vs. low NLR (cutoff 2.5) and PLT (cutoff 300×109/L). Survival was assessed using Kaplan-Meier and log-rank tests, with univariate and multivariate Cox regression to identify independent prognostic factors. Results showed high post-chemotherapy NLR and/or post-chemotherapy PLT as adverse markers.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-counts-during-chemotherapy-in-patients-with-advanced-gastric-cancer/383145/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-value-of-neutrophil-to-lymphocyte-ratio-and-platelet-counts-during-chemotherapy-in-patients-with-advanced-gastric-cancer/383145.png","ImageObject",300,407,{"name":92,"@type":93},"Guten tag","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What biomarkers were evaluated in this study?","Question",{"text":112,"@type":113},"The study evaluated dynamic changes in the neutrophil-to-lymphocyte ratio (NLR) and platelet counts (PLT) in advanced gastric cancer patients during chemotherapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How many patients were included and how were they grouped?",{"text":117,"@type":113},"A total of 259 advanced gastric cancer patients receiving chemotherapy were enrolled and grouped into high or low NLR and high or low PLT using predefined cutoff values.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the key prognostic findings?",{"text":121,"@type":113},"High NLR after chemotherapy and high PLT after chemotherapy were associated with adverse prognosis, while lower post-chemotherapy NLR (or decreasing NLR) related to better overall response and disease control.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383145,1790646179,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},687212321768,"https://ap-avatar.wpscdn.com/avatar/a0010bdbe886d2fe77?x-image-process=image/resize,m_fixed,w_180,h_180&k=1789897067658708522","Original Article  \nPrognostic value of neutrophil to lymphocyte ratio and platelet counts during chemotherapy in patients with advanced gastric cancer  \nBo Li, MD, PhD, Kemeng Wang, MD, PhD, Shuai Shi, MD, PhD, Meng Li, MD, PhD, Min-Ting Ma, MD, PhD,  \nZhi-Guo Zhou, MD, PhD, Zhi-Cong Wang, MD, PhD, Ya-Ning Gong, MD, PhD, Yajie Xiao, MD, PhD, Liyan Zhao, MD, PhD, Qingju Meng, MD, PhD, Yi-Bing Liu, MD, PhD.  \nABSTRACT  \nالأهداف: التحقق من القيمة التنبؤية للتغيرات الديناميكية في نسبة العدلاتإلى الخلايا الليمفاوية (NLR) وعدد الصفائح الدموية (PLT) في المرضى الذينيعانون من GC المتقدم أثناء العلاج الكيميائي.  \nالمنهجية: تم تسجيل 259 مريضً ا متقدمً ا من GC الذين يتلقون العلاجالكيميائي وتجميعهم حسب NLR و PLT المرتفع أو المنخفض، مع صماماتقطع 2.5 و 300×9/L/10لتر، على التوالي. تم إجراء نموذج البقاء على قيد الحياة Kaplan-Meier واختبار رتبة السجل لمقارنة الاختلافات في نظام التشغيل. تمإجراء تحليلات الانحدار وحيد المتغير ومتعدد المتغيرات من خلال تحليل الانحداركوكس للتحقيق في عوامل الإنذار المستقلة المحتملة.  \nالنتائج: ارتبط NLR العالي قبل العلاج الكيميائي بنقائل ودرجة عالية من نوع Borrmann على التوالي ، وكان NLR العالي لمرضى GC قبل العلاج الكيميائيأو بعده مرتبطً ا بدرجة نوع Borrmann. علاوة على ذلك ، ترتبط معدلات PLT المرتفعة بالدرجات المتقدمة من نوع Borrmann. ومن المثير للاهتمام ،أن المرضى الذين يعانون من انخفاض NLR بعد العلاج الكيميائي أو انخفاض NLR لديهم نسبة ORR و DCR أفضل من أولئك الذين لديهم NLR أعلىأو زيادة NLR. علاوة على ذلك، المرضى الذين يعانون من NLR العالي بعدالعلاج الكيميائي وحده أو أعلى بعد العلاج الكيميائي NLR بالإضافة إلى PLT أعلى بعد العلاج الكيميائي كان لها نظام تشغيل ضار.  \nالخلاصة: اقترحت دراستنا أن NLR العالي بعد العلاج الكيميائي و PLT بعدالعلاج الكيميائي قد يكونان علامات تنبؤية سلبية في مرضى GC المتقدمينالذين يخضعون للعلاج الكيميائي.  \nObjectives: To investigate the predictive significance of dynamic changes in the neutrophil to lymphocyte ratio )NLR( and platelet counts )PLTs( in patients with advanced gastric cancer )GC( during chemotherapy.  \nMethods: A total of 259 advanced GC patients receiving chemotherapy were enrolled and grouped by high or low NLR with a cut value of 2.5 and PLT with cut value of 300×109/L. The Kaplan-Meier survival model and the Log-rank test were carried out to determine the comparison on the overall survival differences. Cox regression analysis was employed to carry out both univariate and multivariate regression studies, aiming to explore potential prognostic factors acting independently.  \nResults: Higher pre-chemotherapy NLR exhibited an association with metastasis and advanced grade of Borrmann type, and higher NLR of pre- or postchemotherapy GC patients was related with Borrmann type grade. Moreover, higher PLT counts are associated with advanced grades of Borrmann type. Interestingly, patients with lower post-chemotherapy NLR or decreasing NLR hold better overall response rate and disease control rate than those with higher NLR or increasing NLR. Furthermore, patients with high postchemotherapy NLR alone or higher post-chemotherapy NLR plus higher post-chemotherapy PLT.  \nConclusion: Our study suggested that high postchemotherapy NLR and post-chemotherapy PLT might be adverse prognostic markers in advanced GC patients undergoing chemotherapy.  \nKeywords: neutrophils, lymphocytes, platelets )PLTs(, stomach neoplasms, chemotherapy.  \nSaudi MedJ 2023; Vol. 44 (11): 1104-1112 doi: 10.15537/smj.2023.44.11.20220946  \nFrom the Department Radiology (B. Li); from the Department of Medical Oncology (Ma, Liu), Fourth Hospital of Hebei Medical University, from the Department of Internal Medicine (K. Wang); from the Department of Orthopedics (Meng); from the Department of Medical Oncology (Gong), the first affiliated Hospital of Xingtai Medical College, from the Department of Medical Oncology (M. Li), Quyang cancer hospital/Hengzhou hospital, from the Department of Radiotherapy (Z. Wang), Cangzhou Central Hospital, Hebei, from YuceBio Technology Co. Ltd. (Xiao), Guangdong, China, and from the Departme","cbCail98sqRth6Kv","https://ap.wps.com/l/cbCail98sqRth6Kv","pdf",1237327,"English","# Abstract\n## Objectives\n## Methods\n## Results\n## Conclusion","[{\"question\":\"What biomarkers were evaluated in this study?\",\"answer\":\"The study evaluated dynamic changes in the neutrophil-to-lymphocyte ratio (NLR) and platelet counts (PLT) in advanced gastric cancer patients during chemotherapy.\"},{\"question\":\"How many patients were included and how were they grouped?\",\"answer\":\"A total of 259 advanced gastric cancer patients receiving chemotherapy were enrolled and grouped into high or low NLR and high or low PLT using predefined cutoff values.\"},{\"question\":\"What were the key prognostic findings?\",\"answer\":\"High NLR after chemotherapy and high PLT after chemotherapy were associated with adverse prognosis, while lower post-chemotherapy NLR (or decreasing NLR) related to better overall response and disease control.\"}]","Prognostic value of neutrophil to lymphocyte ratio and platelet counts during chemotherapy in patients with advanced gastric cancer | PDF",1790254468,23]