[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-386243-105":59,"doc-detail-386243-en":129},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":122,"head_meta":124,"extra_data":126,"updated_unix":128},105,"en","prognostic-value-and-immunological-role-of-ptpn21-in-pan-cancer-analysis","Prognostic value and immunological role of PTPN21 in pan-cancer analysis","","Cancer remains a persistent global public health challenge, yet the prognostic potential of PTPN21 across multiple cancers is not fully understood. This study analyzed PTPN21 expression and its prognostic value using TCGA and GEO datasets, explored PTPN21 genetic alterations via cBioPortal, and assessed immune infiltration correlations with TIMER2. It further performed GO/KEGG enrichment and identified PTPN21 as a diagnostic biomarker linked to mutation burden, immune infiltration, and neuroactive ligand-receptor interaction pathways.",{"@graph":69,"@context":121},[70,84,104],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-value-and-immunological-role-of-ptpn21-in-pan-cancer-analysis/386243/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":98,"encodingFormat":97,"isAccessibleForFree":99,"interactionStatistic":100},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-value-and-immunological-role-of-ptpn21-in-pan-cancer-analysis/386243.png","ImageObject",300,407,{"name":92,"@type":93},"Rizky","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-24",true,{"@type":101,"interactionType":102,"userInteractionCount":4},"InteractionCounter",{"@type":103},"ViewAction",{"@type":105,"mainEntity":106},"FAQPage",[107,113,117],{"name":108,"@type":109,"acceptedAnswer":110},"What was the purpose of analyzing PTPN21 in pan-cancer?","Question",{"text":111,"@type":112},"To determine PTPN21 expression patterns and its prognostic value across cancers, and to evaluate how PTPN21 relates to immune infiltration.","Answer",{"name":114,"@type":109,"acceptedAnswer":115},"Which datasets and tools were used for expression, survival, and genetic alteration analysis?",{"text":116,"@type":112},"Expression and survival were assessed using TCGA and GEO, genetic alterations were studied with cBioPortal, and immune infiltration correlations were evaluated using TIMER2.",{"name":118,"@type":109,"acceptedAnswer":119},"What relationships did the study find between PTPN21 and tumors?",{"text":120,"@type":112},"PTPN21 expression correlated with tumor mutations and immune infiltration, and enrichment analysis suggested involvement in neuroactive ligand-receptor interaction regulation.","https://schema.org",{"og:url":83,"og:type":123,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":125,"canonical":83},"index,follow",{"doc_id":127,"site_id":62},386243,1790272899,{"code":4,"msg":5,"data":130},{"doc_id":127,"user_id":131,"nickname":92,"user_avatar":132,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":133,"file_id":134,"file_url":135,"file_type":136,"file_size":137,"view_count":4,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":138,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":128,"read_time":143},962085564807,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Prognostic value and immunological role of PTPN21 in pan-cancer analysis  \nYanE Yang1, WEnChao Yang1, XingXing Su2, CaiXia ChEng2,3  \n1School of Public Health, Shanxi Medical University, China  \n2The First Clinical Medical College, Shanxi Medical University, China 3Department of Pathology, The First Hospital, Shanxi Medical University, China  \nAbstract  \nIntroduction: at present, cancer remains a persistent public health challenge facing the whole world. Studies have found that PTPn21 is associated with the development of cancer. however, the prognostic potential of PTPn21 in pan-cancer remains unclear. in this work, we aimed to analyze the expression and prognostic value of PTPn21 in pan-cancer and to further study the relationship between PTPn21 and immune infiltration.  \nMaterial and methods: TCga and gEo data were used for expression and survival analysis. genetic alterations in PTPn21 from TCga cancer were studied in cBioPortal. TiMER2 was used to evaluate the correlation between PTPN21 expression and immune infiltration. The R packages “ggplot2” and“clusterProfiler” were used for GO and KEGG analysis.  \nResults: PTPn21 was found to be a valuable diagnostic biomarker in multiple cancers, including bladder urothelial carcinoma (BLCA), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), and lung squamous cell carcinoma (LUSC). In addition, we observed that PTPn21 expression was associated with a variety of tumor mutations. our results indicated a correlation between PTPn21 expression and immune infiltration. Enrichment analysis showed that PTPn21 was mainly involved in the regulation of neuroactive ligand-receptor interaction.  \nConclusions: our study showed that PTPn21 expression is associated with clinical prognosis, mutation, and immune infiltration of tumors. PTPn21 may be apotential biomarker for many cancers, especially in KIRC.  \nKey words: PTPn21, prognosis, immune infiltration, mutation, pan-cancer.  \n(Cent Eur Jimmunol 2023; 48 (2): 111-125)  \nIntroduction  \nCancer is a persistent public health challenge facing society. As the second most common cause of death worldwide, cancer is expected to be the most significant obstacle to increasing life expectancy in the 21st century. The burden of cancer is increasing. In the coming decades, the greatest impact and fastest increase in the burden of cancer will continue to occur in developing countries, which not only causes immense suffering to patients but also imposes a heavy economic burden on society and patients’ families [1] .  \nSince the occurrence and development of cancer is a complex and changeable process, various genetic changes may affect the treatment and prognosis of cancer patients [2, 3]. Pan-cancer analysis has been used by a wide range of researchers to explore the correlation between gene expression and clinical outcomes by analyzing large amounts of data from publicly funded databases. For ex-  \nample, previous studies have demonstrated that LAYN, SNLRP3, and SND1 could act as predictive biomarkers for cancer prognosis [4-6] .  \nIn recent years, immunotherapy has been a developing field in oncology [7] . The development of several novel immunomodulatory antibodies has altered the treatment of many cancers, to selectively enhance the host’s immune response to malignant diseases [8] . For instance, programmed death-1 (PD-1), an immune checkpoint molecule, has been recognized as a major target for cancer therapy [9] . Given the growing number of genetic abnormalities in tumors, immunotherapy appears to be a promising treatment option for cancer patients. In addition, tumor-infiltrating immune cells have been proven to influence the prognosis [10] .  \nProtein tyrosine phosphatases (PTPs) are key regulators of cell activity, regulating tyrosine phosphorylation and signal transduction pathways [11] . The PTP family comprises 125 members, which can be divided into three  \nCorrespondence: CaiXia Cheng, The First Clinical Med","cbCaiuGBWkUeKivm","https://ap.wps.com/l/cbCaiuGBWkUeKivm","pdf",3875916,15,"English","# Introduction\n## Cancer burden and pan-cancer analysis\n## Immunotherapy and tumor-infiltrating immune cells\n## Protein tyrosine phosphatases and PTPN21 background\n# Material and methods\n## Expression and survival analysis using TCGA and GEO\n## Genetic alterations via cBioPortal\n## Immune infiltration correlation via TIMER2\n## GO and KEGG analysis with R packages\n# Results\n## Diagnostic biomarker potential across cancers\n## Association with tumor mutations\n## Correlation with immune infiltration\n## Enrichment in neuroactive ligand-receptor interaction regulation\n# Conclusions\n## Clinical prognosis, mutation, and immune infiltration relevance\n## Potential biomarker value, especially in KIRC","[{\"question\":\"What was the purpose of analyzing PTPN21 in pan-cancer?\",\"answer\":\"To determine PTPN21 expression patterns and its prognostic value across cancers, and to evaluate how PTPN21 relates to immune infiltration.\"},{\"question\":\"Which datasets and tools were used for expression, survival, and genetic alteration analysis?\",\"answer\":\"Expression and survival were assessed using TCGA and GEO, genetic alterations were studied with cBioPortal, and immune infiltration correlations were evaluated using TIMER2.\"},{\"question\":\"What relationships did the study find between PTPN21 and tumors?\",\"answer\":\"PTPN21 expression correlated with tumor mutations and immune infiltration, and enrichment analysis suggested involvement in neuroactive ligand-receptor interaction regulation.\"}]","Prognostic value and immunological role of PTPN21 in pan-cancer analysis | PDF",38]