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This study performs pan-cancer analyses of PD-L1 expression, genetic alterations, prognostic associations, and immunological features, evaluating links to survival using pooled odds ratios and hazard ratios with 95% CI. It further examines correlations with MSI, TMB, DNMTs, MMR genes, immune checkpoint biomarkers, and applies immunohistochemistry and qRT-PCR to assess protein and mRNA levels.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-value-and-immunological-role-of-pd-l1-gene-in-pan-cancer/329987/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-value-and-immunological-role-of-pd-l1-gene-in-pan-cancer/329987.png","ImageObject",300,407,{"name":92,"@type":93},"Jiven","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-26","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the research objective regarding PD-L1 in pan-cancer?","Question",{"text":112,"@type":113},"The study aims to clarify PD-L1’s prognostic value and immunological role across human pan-cancers, since it has not been fully investigated.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which methods are used to analyze PD-L1’s prognostic and immunological associations?",{"text":117,"@type":113},"Survival correlations are assessed using pooled odds ratios and hazard ratios with 95% CI, Kaplan–Meier analysis, COX analysis, and ROC curves. Relationships with MSI, TMB, DNMTs, MMR genes, and immune checkpoint biomarkers are evaluated with Spearman correlation.",{"name":119,"@type":110,"acceptedAnswer":120},"What key findings link PD-L1 to tumor biology and the immune microenvironment?",{"text":121,"@type":113},"PD-L1 shows abnormal mRNA and protein expression across cancers and predicts patient prognosis. 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BMC Cancer (2024) 24:20 [https://doi.org/10.1186/s12885-023-11267-6](https://doi.org/10.1186/s12885-023-11267-6)  \nBMC Cancer  \n RESEARCH Open Access  \nPrognostic value and immunological role of PD‑L1 gene in pan-cancer  \nYongfeng Wang1,2,3,4†, Hong Jiang5†, Liangyin Fu2†, Ling Guan5, Jiaxin Yang5, Jingyao Ren2, Fangyu Liu 1, Xiangyang Li1, Xuhui Ma2, Yonghong Li4* and Hui Cai1,2,3,4*  \nAbstract  \nObjective PD-L1, a target of immune checkpoint blockade, has been proven to take the role of an oncogene in most human tumors. However, the role of PD-L1 in human pan-cancers has not yet been fully investigated.  \nMaterials and methods Pan-cancer analysis was conducted to analyze expression, genetic alterations, prognosis analysis, and immunological characteristics of PD-L1 . Estimating the correlation between PD-L1 expression and survival involved using pooled odds ratios and hazard ratios with 95% CI. The Kaplan–Meier (K-M) technique, COX analysis, and receiver operating characteristic (ROC) curves were applied to the survival analysis. Additionally, we investigated the relationships between PD-L1 and microsatellite instability (MSI), tumor mutational burden (TMB), DNA methyltransferases (DNMTs), the associated genes of mismatch repair (MMR), and immune checkpoint biomarkers using Spearman’s correlation analysis. Also, immunohistochemical analysis and qRT-PCR were employed in evaluating PD-L1’s protein and mRNA expression in pan-caner.  \nResults PD-L1 showed abnormal mRNA and protein expression in a variety of cancers and predicted prognosis in cancer patients. Furthermore, across a variety of cancer types, the aberrant PD-L1 expression was connected to the MSI, MMR, TMB, drug sensitivity, and tumor immune microenvironment (TIME) . Moreover, PD-L1 was significantly correlated with infiltrating levels of immune cells (T cell CD8 + , neutrophil, and so on) .  \nConclusion Our study provides a better theoretical basis and guidance for the clinical treatment of PD-L1 . Keywords PD-L1, Prognosis, Cancers, Bioinformatics analysis  \n†Yongfeng Wang, Hong Jiang, and Liangyin Fu were the co-first authors.  \n*Correspondence: Yonghong Li [haifenglyh@126.com](haifenglyh@126.com)[ ](haifenglyh@126.com)Hui Cai[caialonteam@163.com](caialonteam@163.com)  \n1 The First Clinical Medical College of Lanzhou University, Lanzhou, Gansu 730000, China  \n2 General Surgery Clinical Medical Center, Gansu Provincial Hospital, Lanzhou, Gansu 730000, China  \n3 Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology in Gansu Province, Gansu Provincial Hospital, Gansu 730000, China  \n4 NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor, Gansu Provincial Hospital, 204 Donggang West Road, Lanzhou, Gansu 730000, China  \n5 School of Stomatology, Lanzhou University, Lanzhou, Gansu 730000, China  \n© The Author(s) 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[htt","cbCaiuCh65w5tTXb","https://ap.wps.com/l/cbCaiuCh65w5tTXb","pdf",16427256,"English","# Abstract\n# Objective\n# Materials and methods\n# Results\n# Conclusion\n# Keywords","[{\"question\":\"What is the research objective regarding PD-L1 in pan-cancer?\",\"answer\":\"The study aims to clarify PD-L1’s prognostic value and immunological role across human pan-cancers, since it has not been fully investigated.\"},{\"question\":\"Which methods are used to analyze PD-L1’s prognostic and immunological associations?\",\"answer\":\"Survival correlations are assessed using pooled odds ratios and hazard ratios with 95% CI, Kaplan–Meier analysis, COX analysis, and ROC curves. Relationships with MSI, TMB, DNMTs, MMR genes, and immune checkpoint biomarkers are evaluated with Spearman correlation.\"},{\"question\":\"What key findings link PD-L1 to tumor biology and the immune microenvironment?\",\"answer\":\"PD-L1 shows abnormal mRNA and protein expression across cancers and predicts patient prognosis. Aberrant PD-L1 expression correlates with MSI, MMR, TMB, drug sensitivity, TIME, and infiltration levels of immune cells including CD8+ T cells and neutrophils.\"}]","Prognostic value and immunological role of PD-L1 gene in pan-cancer | PDF",1789986465,48]