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TIMER2.0 and immune-related algorithms assess tumor microenvironment changes, supported by GO/KEGG and GSEA to clarify cancer pathways and biological functions. TMED9 is proposed to remodel the TME and influence immunotherapeutic response.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/prognostic-value-and-anti-tumor-immunity-role-of-tmed9-in-pan-cancer-a-bioinformatics-study/331500/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/prognostic-value-and-anti-tumor-immunity-role-of-tmed9-in-pan-cancer-a-bioinformatics-study/331500.png","ImageObject",300,407,{"name":42,"@type":43},"Eden","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-04","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the main aim of the study on TMED9?","Question",{"text":63,"@type":64},"To evaluate the prognostic value of TMED9 and its role in anti-tumor immunity across pan-cancers.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was TMED9’s prognostic impact assessed?",{"text":68,"@type":64},"TMED9 expression was linked to clinical outcomes and patient survival using Kaplan-Meier curves, log-rank tests, and Cox regression (univariate and multivariate).",{"name":70,"@type":61,"acceptedAnswer":71},"What does the study report about TMED9 in the tumor microenvironment?",{"text":72,"@type":64},"TMED9 expression correlates with changes in the infiltration levels of immune cells and cancer-associated fibroblasts, suggesting it may reshape the TME and affect immunotherapy response.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},331500,1791031303,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Prognostic value and anti-tumor immunity role of TMED9 in pan-cancer: a bioinformatics study  \nHaodi Wang1\\#, Yue Wang2\\#, Pengyu Tan1, Yichi Liu1, Sa Zhou1, Wenjian Ma1,3  \n1College of Biotechnology, Tianjin University of Science and Technology, Tianjin, China; 2College of Future Education, Beijing Normal University at Zhuhai, Zhuhai, China; 3College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan, China  \nContributions: (I) Conception and design: H Wang, Y Wang; (II) Administrative support: W Ma; (III) Provision of study materials or patients: Y Wang, Y Liu; (IV) Collection and assembly of data: H Wang, P Tan; (V) Data analysis and interpretation: H Wang, S Zhou; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work as co-first authors.  \nCorrespondence to: Wenjian Ma, PhD. Professor, College of Biotechnology, Tianjin University of Science and Technology, 29\\# 13th Ave., Binhai TEDA, Tianjin 300457, China; College of Biological and Chemical Engineering, Qilu Institute of Technology, Jinan, [China. Email: ma_wj@tust.edu.cn](China. Email: ma_wj@tust.edu.cn).  \nBackground: Transmembrane p24 trafficking protein 9 ( TMED9) belongs to the TMED family, and its overexpression frequently induces cancer. Studies have demonstrated the association between the overexpression of TMED9 and cancer development and proliferative migration in cancers such as ovarian cancer, hepatocellular carcinoma, and breast cancer. However, there has been no study investigating the clinical value, biological function, and anti-tumor immune effects of TMED9 from a pan-cancer perspective.  \nThe aim of this study is to evaluate the prognostic value and anti-tumor immunity role of TMED9 across  \npan-cancers.  \nMethods: We utilized R language along with The Cancer Genome Atlas (TCGA), UCSC Xena (University of California, Santa Cruz Xena Browser), Human Protein Atlas (HPA), and other datasets to investigate TMED9 expression in various tumors. The association between high TMED9 expression and clinical prognosis and patient survival was examined using the Kaplan-Meier method, log-rank test, as well as univariate and multivariate Cox regression analyses. Tumor Immune Estimation Resource 2.0 (TIMER2.0) and various algorithms were employed to explore the relationship between TMED9 and the tumor microenvironment (TME). Additionally, the biological function of TMED9 in cancer was investigated through Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and gene set  \nenrichment analysis (GSEA) analyses.  \nResults: TMED9 was over-expressed in the majority of cancers. Patients exhibiting elevated TMED9 expression typically experienced diminished survival rates and unfavorable clinical outcomes. TMED9 played a role as a mediator in the aggressive phenotype of numerous tumors, actively engaging in various biological and signaling pathways linked to cancer development. TMED9 demonstrated the capacity to modulate the anti-tumor immune response in pan-cancer patients, exerting its influence on the infiltration levels of  \nimmune cells and cancer-associated fibroblasts (CAFs) .  \nConclusions: TMED9 serves as a novel “cancer indicator” and “clinical prognostic marker”, capable of reshaping the TME, impacting the immunotherapeutic response, and guiding precise treatments for cancers  \nto a certain extent.  \nKeywords: Transmembrane p24 trafficking protein 9 (TMED9); pan-cancer analysis; prognosis biomarker; tumor  \nmicroenvironment (TME); cancer immunity  \nSubmitted Feb 17, 2024. Accepted for publication Jul 07, 2024. Published online Sep 11, 2024.  \ndoi: 10.21037/tcr-24-258  \nView this article at: [https://dx.doi.org/10.21037/tcr-24-258](https://dx.doi.org/10.21037/tcr-24-258)  \n© AME Publishing Company. Transl Cancer Res 2024;13(10):5429-5445 | [https://dx.doi.org/10.21037/tcr-24-258](https://dx.doi.org/10.21037/tcr-24-258)  \n5430 Wang et al. TMED9’s pro","cbCait5qMX9sv9G4","https://ap.wps.com/l/cbCait5qMX9sv9G4","pdf",3120697,17,"English","# Background\n## Methods\n## Results\n## Conclusions\n## Introduction","[{\"question\":\"What is the main aim of the study on TMED9?\",\"answer\":\"To evaluate the prognostic value of TMED9 and its role in anti-tumor immunity across pan-cancers.\"},{\"question\":\"How was TMED9’s prognostic impact assessed?\",\"answer\":\"TMED9 expression was linked to clinical outcomes and patient survival using Kaplan-Meier curves, log-rank tests, and Cox regression (univariate and multivariate).\"},{\"question\":\"What does the study report about TMED9 in the tumor microenvironment?\",\"answer\":\"TMED9 expression correlates with changes in the infiltration levels of immune cells and cancer-associated fibroblasts, suggesting it may reshape the TME and affect immunotherapy response.\"}]","Prognostic value and anti-tumor immunity role of TMED9 in pan-cancer - a bioinformatics study | PDF",1789993601,43]