[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-356948-105":3,"doc-detail-356948-en":80,"detail-sidebar-cat-0-en-105":98},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":73,"head_meta":75,"extra_data":77,"updated_unix":79},105,"en","prognostic-significance-of-lymphovascular-invasion-in-breast-cancer-insights-from-a-retrospective-analysis-at-a-tertiary-care-center","Prognostic Significance of Lymphovascular Invasion in Breast Cancer - Insights From a Retrospective Analysis at a Tertiary Care Center","","Objective: Explore the relationship between lymphovascular invasion (LVI) and outcomes across histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities in breast cancer. Methods: Retrospectively reviewed 828 women with invasive breast carcinoma treated at King Abdulaziz University Hospital (2010–2020). OS and EFS were estimated using Kaplan–Meier curves and assessed with stepwise Cox models. Results: LVI appeared in 31.5% of cases and predicted significantly worse OS and EFS, with persistent adverse effects across subgroups.",{"@graph":14,"@context":72},[15,34,55],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/prognostic-significance-of-lymphovascular-invasion-in-breast-cancer-insights-from-a-retrospective-analysis-at-a-tertiary-care-center/356948/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/prognostic-significance-of-lymphovascular-invasion-in-breast-cancer-insights-from-a-retrospective-analysis-at-a-tertiary-care-center/356948.png","ImageObject",300,407,{"name":42,"@type":43},"eBook King","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-09-27","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":30},"InteractionCounter",{"@type":54},"ViewAction",{"@type":56,"mainEntity":57},"FAQPage",[58,64,68],{"name":59,"@type":60,"acceptedAnswer":61},"What study objective focuses on lymphovascular invasion (LVI) in breast cancer?","Question",{"text":62,"@type":63},"The study examines how LVI relates to outcomes across histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities.","Answer",{"name":65,"@type":60,"acceptedAnswer":66},"How was the prognostic impact of LVI evaluated?",{"text":67,"@type":63},"OS and EFS were estimated using Kaplan–Meier curves, and independent predictors were identified using stepwise Cox models with multivariable adjustment.",{"name":69,"@type":60,"acceptedAnswer":70},"What were the key survival findings associated with LVI?",{"text":71,"@type":63},"Patients with LVI showed significantly reduced mean overall survival and event-free survival, and LVI remained an independent predictor of poorer EFS after adjustment.","https://schema.org",{"og:url":32,"og:type":74,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":76,"canonical":32},"index,follow",{"doc_id":78,"site_id":7},356948,1790466940,{"code":4,"msg":81,"data":82},"success",{"doc_id":78,"user_id":83,"nickname":42,"user_avatar":84,"doc_module":4,"category_id":85,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":86,"file_id":87,"file_url":88,"file_type":89,"file_size":90,"view_count":30,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":91,"language":92,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":93,"faqs":94,"seo_title":95,"seo_description":12,"update_tm":96,"read_time":97},962088006270,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45",8,"SAUDI MEDICAL JOURNAL 2026;47:461–469 Scan the QR to view  \nthe full-text article on the journal website  \nORIGINAL ARTICLE  \nPrognostic Significance of Lymphovascular Invasion in Breast Cancer: Insights From a Retrospective Analysis at a Tertiary Care Center  \nNora Trabulsi, MBBS, MSc a,*, Shayma Alotaibi, MBBS b, Mohammed Bahabri, MBBS c, Hussain A. Alkhalifah, MBBS c,  \nGhady D. Alshehri, MBBS d, Sultan K. Alshali, MBBS e, Ali Farsi, MBBS, FRCSC a, Marwan Alhajeili, MD, MS f, Hassan Al-turki, MBBS, MPH, FRCSc a,  \nSalma Sait, MBBS g, Alaa Shabkah, MBBS g, Rana Ajaboor, MBBS h, Hessa Aljhdali, MBBS h  \na Department of Surgery, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia b Department of General Surgery, King Abdulaziz Hospital, Jeddah, Saudi Arabia  \nc Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia  \nd Department of Neurosciences, King Faisal Specialist Hospital & Research Center, Jeddah, Saudi Arabia e Department of Surgery, Saudi German Hospital, Jeddah, Saudi Arabia  \nf Department of Medicine, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia g Department of Surgery, International Medical Center, Jeddah, Saudi Arabia  \nh Department of Anatomical Pathology, Faculty of Medicine, King Abdulaziz University Hospital, King Abdulaziz University, Jeddah, Saudi Arabia  \nABSTRACT  \nObjective: To explore the relationship between lymphovascular invasion (LVI) and outcomes across different histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities. Lymphovascular invasion is a well-recognized histopathological feature associated with tumor dissemination in breast cancer. However, its prognostic weight is under-reported in Middle Eastern cohorts.  \nMethods: We retrospectively reviewed data from 828 women treated for invasive breast carcinoma at King Abdulaziz University Hospital from 2010 to 2020. Clinicopathologic variables, treatments, and outcomes were extracted. Overall survival (OS) and event-free survival (EFS) were estimated and tested using Kaplan–Meier curves; independent predictors were identified with stepwise Cox models.  \nResults: Lymphovascular invasion was identified in 31.5% of cases, and Kaplan–Meier analysis revealed significantly reduced mean OS (9.94 vs. 12.43 years; p \u003C 0.001) and EFS (8.33 vs. 11.23 years; p \u003C 0.001) in these patients. Multivariable analysis adjusted for established clinicopathological covariates indicated LVI as an independent predictor of poorer EFS (HR D 1.909, 95% CI 1.218–2.992; p D 0.005). Additionally, positive estrogen receptor status conferred lower risk (HR D 0.543; 95% CI: 0.345–0.853; p D 0.008), while higher pathological N stages (N2 and N3) were correlated with significantly increased hazard ratios for recurrence or death (HR D 3.515 and 4.479, respectively; both p \u003C 0.01). Notably, the adverse prognostic impact of LVI persisted across different histological subtypes, hormonal profiles, and treatment modalities.  \nReceived 26 July 2025; accepted 18 October 2025.  \nAvailable online 10 March 2026  \n* Corresponding author.  \nE-mail [addresses:](addresses: Noratrabulsi@gmail.com)[ Noratrabulsi@gmail.com](addresses: Noratrabulsi@gmail.com) (N. Trabulsi), [Otaibi.shayma@gmail.com](Otaibi.shayma@gmail.com) (S. Alotaibi), [Bahabry1999@gmail.com](Bahabry1999@gmail.com) (M. Bahabri),  \n[Hussainalkhalifa7@gmail.com](Hussainalkhalifa7@gmail.com) (H. A. Alkhalifah), [ghadydhafer@gmail.com](ghadydhafer@gmail.com) (G. D. Alshehri), [sultankalshali@gmail.com](sultankalshali@gmail.com) (S. K. Alshali),  \n[alihmfarsi@gmail.com](alihmfarsi@gmail.com) (A. Farsi), [Marwan.alhajeili@gmail.com](Marwan.alhajeili@gmail.com) (M. Alhajeili), [Hassan.alturki@gmail.com](Hassan.alturki@gmail.com) (H. Al-turki), [salmasait93@gmail.com](salmasait93@gmail.com) (S. Sait),  \n[aashabkah@gmail.com](aashabkah@gmail.com) (A. Shabkah), [Rajabnoor@kau.edu.sa](Rajabnoor@kau.edu.sa) (R. Ajaboor), [haljhdali@kau.edu.sa](","cbCaid4Q0AdQF7Fs","https://ap.wps.com/l/cbCaid4Q0AdQF7Fs","pdf",4252432,9,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Introduction\n## Background on breast cancer incidence and variability\n## Definition and clinical relevance of LVI\n# Methods and Analysis\n## Data source and cohort\n## Survival analysis approach\n## Predictor modeling","[{\"question\":\"What study objective focuses on lymphovascular invasion (LVI) in breast cancer?\",\"answer\":\"The study examines how LVI relates to outcomes across histopathological subtypes, tumor grades, clinical stages, hormone receptor profiles, and treatment modalities.\"},{\"question\":\"How was the prognostic impact of LVI evaluated?\",\"answer\":\"OS and EFS were estimated using Kaplan–Meier curves, and independent predictors were identified using stepwise Cox models with multivariable adjustment.\"},{\"question\":\"What were the key survival findings associated with LVI?\",\"answer\":\"Patients with LVI showed significantly reduced mean overall survival and event-free survival, and LVI remained an independent predictor of poorer EFS after adjustment.\"}]","Prognostic Significance of Lymphovascular Invasion in Breast Cancer - Insights From a Retrospective Analysis at a Tertiary Care Center | PDF",1790128402,23,{"code":4,"msg":81,"data":99},[100,104,108,112,117,122,127,130,134,137,141],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":101,"show_sort_weight":102,"slug":103},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":105,"show_sort_weight":106,"slug":107},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":109,"show_sort_weight":110,"slug":111},"Exam",70,"exam",{"id":113,"doc_module":4,"doc_module_name":25,"category_name":114,"show_sort_weight":115,"slug":116},5,"Comic",60,"comic",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":119,"show_sort_weight":120,"slug":121},6,"Technology",50,"technology",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":125,"slug":126},7,"Healthcare",40,"healthcare",{"id":85,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":128,"slug":129},30,"research-report",{"id":91,"doc_module":4,"doc_module_name":25,"category_name":131,"show_sort_weight":132,"slug":133},"Religion & Spirituality",20,"religion-spirituality",{"id":132,"doc_module":4,"doc_module_name":25,"category_name":135,"show_sort_weight":132,"slug":136},"World Cup","world-cup",{"id":138,"doc_module":4,"doc_module_name":25,"category_name":139,"show_sort_weight":138,"slug":140},10,"Lifestyle","lifestyle",{"id":142,"doc_module":4,"doc_module_name":25,"category_name":143,"show_sort_weight":113,"slug":144},19,"General","general"]