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This study evaluates whether gut and tissue microbiota can serve as prognostic biomarkers linked to treatment outcomes. In 30 ICCA patients treated with cisplatin and gemcitabine, gut bacterial profiles differed by response and survival, including effects of Opisthorchis viverrini infection. Higher Acidaminococcus and Sutterella and lower NK4A214_group, Lachnospiraceae_FCS020_group, and UCG-010 related to poor outcomes.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-role-of-gut-microbiota-and-clinical-parameters-in-predicting-survival-in-advanced-cholangiocarcinoma-patients-receiving-chemotherapy/354335/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-role-of-gut-microbiota-and-clinical-parameters-in-predicting-survival-in-advanced-cholangiocarcinoma-patients-receiving-chemotherapy/354335.png","ImageObject",300,407,{"name":92,"@type":93},"Elsa","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the primary aim of the study?","Question",{"text":112,"@type":113},"To investigate whether gut and tissue microbiota can function as prognostic biomarkers associated with survival and chemotherapy outcomes in advanced intrahepatic cholangiocarcinoma patients.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were gut and tissue microbiota measured?",{"text":117,"@type":113},"Gut bacterial profiles were characterized from pre-treatment fecal samples using 16S rRNA sequencing, while tissue bacterial profiles were determined by real-time qPCR.",{"name":119,"@type":110,"acceptedAnswer":120},"Which gut microbiota patterns were linked to clinical outcomes?",{"text":121,"@type":113},"Gut microbiota differed by chemotherapy response, PFS, overall survival, and Opisthorchis viverrini infection. Acidaminococcus and Sutterella increased with poor outcomes, while NK4A214_group, Lachnospiraceae_FCS020_group, and UCG-010 decreased with poor outcomes.",{"name":123,"@type":110,"acceptedAnswer":124},"Did tissue microbiota differ between cholangiocarcinoma and hepatocellular carcinoma?",{"text":125,"@type":113},"Among total 70 patients, bacterial profiles from ICCA and HCC tissues did not significantly differ.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},354335,1790195090,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149},137455077381,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","Ivyspring  \nInternational Publisher  \nInternationalJournal of Medical Sciences  \n2026; 23(7): 2448-2461. doi: 10.7150/ijms.131376  \nResearch Paper  \nPrognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy  \nThanika Ketpueak1, Chanon Kunasol2,3, Kanokphong Suparan2,3,4, Nakarin Inmutto5, Sunhawit Junrungsee6, Nattayaporn Apaijai3,7, Sasiwan Kerdphoo2,3,7, Chanisa Thonusin2,3,7, Chaiyut Charoentum1, Thatthan Suksombooncharoen1, Sarawut Kongkarnka8, Sirinart Kumfu3,7, Lakkhana Sadaow9,10, Wanchai Maleewong9,10, Siriporn C. Chattipakorn2,3,11, Nipon Chattipakorn2,3,7􀀍  \n1. Division of Oncology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n2. Neurophysiology Unit, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n3. Center of Excellence in Cardiac Electrophysiology Research, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n4. Immunology Unit, Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n5. Department of Radiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n6. Department of Surgery, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n7. Cardiac Electrophysiology Unit, Department of Physiology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n8. Department of Pathology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n9. Mekong Health Science Research Institute, Khon Kaen University, Khon Kaen, Thailand, 40002.  \n10. Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand, 40002.  \n11. Department of Oral Biology and Diagnostic Sciences, Faculty of Dentistry, Chiang Mai University, Chiang Mai, Thailand, 50200.  \n􀀍 Corresponding author: Nipon Chattipakorn, MD, PhD, Cardiac Electrophysiology Research and Training Center, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand; Tel: 011-66-53-935-329, Fax: 011-66-53-935-368; [Email: nchattip@gmail.com](Email: nchattip@gmail.com), [nipon.chat@cmu.ac.th](nipon.chat@cmu.ac.th).  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [https://ivyspring.com/terms](https://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2026.01.13; Accepted: 2026.04.14; Published: 2026.06.10  \nAbstract  \nIntroduction: Cholangiocarcinoma (CCA) is high prevalent in Asia. Emerging evidence indicates gut and tissue microbiota are involved in CCA carcinogenesis and progression. This study investigated the potential role of gut and tissue microbiota as prognostic biomarkers associated with treatment outcomesin advanced intrahepatic CCA (ICCA) patients.  \nMethods: This prospective study comprised two cohorts: hepatocellular carcinoma (HCC) or ICCA patients undergoing surgery or biopsy, and unresectable ICCA patients treated with cisplatin and gemcitabine. Gut bacterial profiles were characterized from pre-treatment fecal samples using 16S rRNA and analyzed with clinical outcomes. Tissue bacterial profiles were determined by real-time qPCR. Results: In 30 ICCA patients receiving chemotherapy, gut microbiota differed based on chemotherapy response, PFS, overall survival, and Opisthorchis viverrini infection. An increase in Acidaminococcus and Sutterella, along with a decrease in NK4A214_group, Lachnospiraceae_FCS020_group, and UCG-010, were associated with poor clinical outcomes. Notably, Intestinimonas levels were significantly associated with less progression of disease within six months (aOR 0.92). Of total 70 patients, bacterial profiles of ICCA and HCC tissues did not significantly differ.  ","cbCairK0qXG2D5RH","https://ap.wps.com/l/cbCairK0qXG2D5RH","pdf",9441607,14,"English","# Abstract\n## Introduction\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What was the primary aim of the study?\",\"answer\":\"To investigate whether gut and tissue microbiota can function as prognostic biomarkers associated with survival and chemotherapy outcomes in advanced intrahepatic cholangiocarcinoma patients.\"},{\"question\":\"How were gut and tissue microbiota measured?\",\"answer\":\"Gut bacterial profiles were characterized from pre-treatment fecal samples using 16S rRNA sequencing, while tissue bacterial profiles were determined by real-time qPCR.\"},{\"question\":\"Which gut microbiota patterns were linked to clinical outcomes?\",\"answer\":\"Gut microbiota differed by chemotherapy response, PFS, overall survival, and Opisthorchis viverrini infection. Acidaminococcus and Sutterella increased with poor outcomes, while NK4A214_group, Lachnospiraceae_FCS020_group, and UCG-010 decreased with poor outcomes.\"},{\"question\":\"Did tissue microbiota differ between cholangiocarcinoma and hepatocellular carcinoma?\",\"answer\":\"Among total 70 patients, bacterial profiles from ICCA and HCC tissues did not significantly differ.\"}]","Prognostic Role of Gut Microbiota and Clinical Parameters in Predicting Survival in Advanced Cholangiocarcinoma Patients Receiving Chemotherapy | PDF",1790110168,35]