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EMR1 mRNA was measured in primary tumors (n=66) and regional lymph nodes (n=377) from 121 colon cancer patients. Disease-free survival from Kaplan–Meier and hazard ratios from uni- and multivariate Cox regression showed high EMR1 in lymph nodes predicted worse outcomes, while high EMR1 in primary tumors predicted better prognosis. Combined EMR1 and CXCL17 further stratified very poor-risk patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-role-of-emr1-in-lymph-nodes-and-primary-tumors-of-colon-cancer-patients-research-article/356072/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-role-of-emr1-in-lymph-nodes-and-primary-tumors-of-colon-cancer-patients-research-article/356072.png","ImageObject",300,407,{"name":92,"@type":93},"PakDamar76","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the main purpose of this study on EMR1?","Question",{"text":112,"@type":113},"To determine whether EMR1, an eosinophil biomarker ectopically expressed in colon cancer tumor cells, can be used to identify patients at risk for relapse after curative surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were EMR1 levels measured and in which samples?",{"text":117,"@type":113},"EMR1 mRNA levels were measured in primary tumors (n=66) and lymph nodes (n=377) from 121 colon cancer patients.",{"name":119,"@type":110,"acceptedAnswer":120},"How did EMR1 relate to prognosis in lymph nodes versus primary tumors?",{"text":121,"@type":113},"High EMR1 levels in regional lymph nodes were associated with poor prognosis, whereas high EMR1 levels in the primary tumor were associated with good prognosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},356072,1790537091,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},962090893057,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Advanced Biology  \n[www.advanced-bio.com](www.advanced-bio.com)  \n RESEARCH ARTICLE   \nPrognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients  \nTamer Roshdy1, 2, 3  Hagar Eltorky1, 2, 4  Alaa Mohamed1, 2, 4  Faten Zahran4  Adel Guirgis3  Lina Olsson1  Gudrun Lindmark5  Marie-Louise Hammarström1  Sten Hammarström1  Basel Sitohy1, 2   \n1 Department of Clinical Microbiology, Umeå University, Umeå, Sweden  2 Department of Diagnostics and Intervention, Oncology, Umeå University, Umeå, Sweden  3 Department of Molecular Biology, Genetic Engineering, and Biotechnology Research Institute, University of Sadat City, Sadat City, Menoufia, Egypt   \n4 Department of Biochemistry, Faculty of Science, Zagazig University, Zagazig, Egypt  5Institution of Clinical Sciences, Lund University, Lund, Sweden Correspondence: Basel Sitohy (basel.sitohy@umu.se)  \nReceived: 21 October 2025  Revised: 28 July 2026  Accepted: 31 July 2026  \nKeywords: CEA | CXCL16 | CXCL17 | EMR1 | eosinophilic biomarker | LGR6 | regional lymph nodes  \nABSTRACT  \nThe purpose was to investigate whether the eosinophil biomarker EMR1, ectopically expressed in colon cancer tumor cells, could be used to identify patients at risk for relapse after curative surgery. EMR1 mRNA levels were determined in primary tumors (n = 66) and lymph nodes (LNs; n = 377) from 121 colon cancer patients. Controls were resection margins of colon cancer tumorsand LNs from patients with inflammatory bowel disease. Primary read-out was recurrency evaluated as disease-free survival time in the Kaplan–Meier survival model and hazard ratio calculation by uni-and multivariate Cox regression. High EMR1 levels in the regional LNs were associated with poor prognosis [hazard ratio 3.1 (1.2–8.0) at 5-year follow-up, p = 0.02] . Patients with a very poor prognosis were identified by combining EMR1 with CXCL17 analysis of LNs [hazard ratio 4.6 (1.1–19.7), p = 0.04] . High EMR1 levels in the primary tumor were associated with a good prognosis [hazard ratio 0.1 (0.02–0.9), p = 0.04] . Multivariate analysis strengthened the result for LNs but weakened the result for the primary tumor. These contradictory prognostic results probably relate to the prominent eosinophilia in the primary tumor, essentially lacking in LNs, where ectopically expressed EMR1 in tumor cells dominates. Thus, EMR1 expressed in tumor cells probably promotes tumor growth.  \n1  Introduction  \nColorectal cancer (CRC) ranks among the leading causes of cancer-related mortality and is the third most prevalent form of malignancy worldwide, with a growing frequency [1] . The primary treatment strategy for CRC is still surgery, which is often combined with other treatments such as radiotherapy, chemotherapy, anti-angiogenic therapy, and immunotherapy [2–5] . Approximately 25% of CRC patients undergoing curative resection experience recurrence, resulting in significant mortality rates [6, 7] . Identifying high-risk patients is crucial in order  \nto provide them with the best possible postoperative treatment options and follow-up care.  \nTumor progression in colon cancer involves tumor cells migrating from the primary intestinal site to form colonies in the regional lymph nodes (LNs) and finally in peripheral organs like the liver and lung. It will depend on the properties of the tumor cells themselves and the microenvironment, including growth-promoting activated fibroblasts and the protective forces of innate and adaptive immunity. Studies exhibited that CD8+T cells contribute significantly to adaptive  \nTamer Roshdy and Hagar Eltorky contributed equally to this study.  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Advanced Biology published by Wiley-VCH GmbH  \nAdvanced Biology, 2026; 10:e00645 1 of 14  \n[https://doi.org/10.1002/adbi.202500645](https:","cbCaijQe4kqga5dg","https://ap.wps.com/l/cbCaijQe4kqga5dg","pdf",3161368,14,"English","# Introduction\n## Colorectal cancer treatment and recurrence risk\n## Immune microenvironment and eosinophil roles\n## EMR1/ADGRE1 as a biomarker in colon cancer","[{\"question\":\"What was the main purpose of this study on EMR1?\",\"answer\":\"To determine whether EMR1, an eosinophil biomarker ectopically expressed in colon cancer tumor cells, can be used to identify patients at risk for relapse after curative surgery.\"},{\"question\":\"How were EMR1 levels measured and in which samples?\",\"answer\":\"EMR1 mRNA levels were measured in primary tumors (n=66) and lymph nodes (n=377) from 121 colon cancer patients.\"},{\"question\":\"How did EMR1 relate to prognosis in lymph nodes versus primary tumors?\",\"answer\":\"High EMR1 levels in regional lymph nodes were associated with poor prognosis, whereas high EMR1 levels in the primary tumor were associated with good prognosis.\"}]","Prognostic Role of EMR1 in Lymph Nodes and Primary Tumors of Colon Cancer Patients - Research Article | PDF",1790123279,35]