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Materials and Methods: Retrospectively analyze 115 patients with recurrence after curative gastrectomy, categorizing recurrence into lymph node, peritoneum, other single organs, and multiple lesions, comparing clinicopathologic features and survival. Results: Peritoneum was the most common site (33%); recurrence-after surgery was similar across sites, but survival after recurrence differed significantly, with peritoneal and multiple lesions worse. Conclusions: Recurrence sites may carry distinct prognostic impacts; peritoneal recurrence may be less responsive to chemotherapy and tends to occur later.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-relevance-of-recurrent-sites-of-gastric-cancer-treated-with-curative-resection-a-single-center-retrospective-study/332198/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-relevance-of-recurrent-sites-of-gastric-cancer-treated-with-curative-resection-a-single-center-retrospective-study/332198.png","ImageObject",300,407,{"name":92,"@type":93},"Maeve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What recurrence sites were analyzed in this study?","Question",{"text":113,"@type":114},"Recurrence was divided into four groups: lymph node (LN), peritoneum, other single organs, and multiple lesions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Did survival after surgery differ between recurrence sites?",{"text":118,"@type":114},"Survival after resection did not show a statistically significant difference across recurrence sites.",{"name":120,"@type":111,"acceptedAnswer":121},"Which recurrence sites were associated with worse prognosis after recurrence?",{"text":122,"@type":114},"Patients with peritoneal recurrence and multiple lesion recurrences had significantly worse survival after recurrence.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},332198,1790090145,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},5909877438554,"https://ap-avatar.wpscdn.com/avatar/5600025385ad2bf12a7?_k=1778553567797529272","J Gastric Cancer. 2024 Jul;24(3):291-299 [https://doi.org/10.5230/jgc.2024.24.e23](https://doi.org/10.5230/jgc.2024.24.e23)[ ](https://doi.org/10.5230/jgc.2024.24.e23)pISSN 2093-582X·eISSN 2093-5641  \nOriginal Article  \nReceived: Apr 1, 2024  \nRevised: Apr 30, 2024  \nAccepted: May 13, 2024  \nPublished online: May 29, 2024  \nCorrespondence to  \nMasato Hayashi  \nDepartment of Surgery, Tochigi Cancer Center Hospital, 4-9-13 Yonan, Utsunomiya, Tochigi 320-0834, Japan.  \nEmail: [sas.jtf@gmail.com](sas.jtf@gmail.com)  \nCopyright © 2024. Korean Gastric Cancer Association  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://](https://)[ ](https://)[creativecommons.org/licenses/by-nc/4.0](creativecommons.org/licenses/by-nc/4.0)) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nConflict of Interest  \nNo potential conflict of interest relevant to this article was reported.  \nAuthor Contributions  \nConceptualization: H. M.; Data curation: F.T., M. H.; Writing-original draft: H. M.  \nPrognostic Relevance of Recurrent Sites of Gastric Cancer Treated With Curative Resection: A Single Center Retrospective Study  \nMasato Hayashi, Takeshi Fujita, Hisayuki Matsushita  \nDepartment of Surgery, Tochigi Cancer Center Hospital, Utsunomiya, Japan  \nABSTRACT  \nPurpose: Gastric cancer treated with curative resection exhibits several recurrence patterns. The peritoneum is the most common site of recurrence. Some reports have indicated different prognostic influences according to the recurrence sites in other cancers, such as esophageal and colorectal cancers. This study investigated whether the recurrence sites influenced the prognosis of patients with recurrent gastric cancer.  \nMaterials and Methods: The data of 115 patients who experienced tumor recurrence after curative gastrectomy were retrospectively reviewed. The sites of recurrence were divided into 4 groups: lymph node (LN), peritoneum, other single organs, and multiple lesions. Clinicopathological features were compared between the sites of recurrence. Prognosis after resection and recurrence were also compared.  \nResults: The peritoneum was the primary site of recurrence in 38 patients (33%) . The tumor differentiation and pathological stages were significantly different. Survival after surgery did not show a statistically significant difference (hazard ratio [HR] of LN: 1, peritoneum: 1.083, other single organs: 1.025, and multiple lesions: 1.058; P=1.00) . Survival after recurrence was significantly different (HR of LN, 1; peritoneum, 2.164; other single organs, 1.092; multiple lesions, 1.554; P=0.01), and patients with peritoneal and multiple lesion recurrences had worse prognosis. Furthermore, peritoneal recurrence seemed to occur later than that at other sites; the median times to recurrence in LN, peritoneal, other single-organ, and multiple lesions were 265, 722, 372, and 325 days, respectively.  \nConclusions: The sites of gastric cancer recurrence may have different prognostic effects. Peritoneal recurrence may be less sensitive to chemotherapy and occur during the late phase of recurrence.  \nKeywords: Gastric cancer; Recurrence; Prognosis  \nINTRODUCTION  \nThe prognosis of gastric cancer has improved owing to advancements in surgical techniques and chemotherapy [1]. Advancements in systemic chemotherapy have especially improved the prognosis ofunresectable and recurrent gastric cancers, as S-1 and cisplatin treatment have shown efficacy [2,3]. New drug options for gastric cancer are the most plausible reasons  \n[https://jgc-online.org](https://jgc-online.org) 291  \nRecurrence Sites and Prognosis  \nfor this prognostic improvement [4-7]. However, the prognosis for patients with recurrent gastric cancer remains poor. Therefore, novel treatment options and drugs are required.  \nThere are several patterns of recurrent gastric","cbCaisSFaKLZxkhA","https://ap.wps.com/l/cbCaisSFaKLZxkhA","pdf",912532,"English","# ABSTRACT\n# INTRODUCTION\n# MATERIALS AND METHODS\n## Patients\n## Detection of recurrence and recurrent groups\n# Recurrence Sites and Prognosis","[{\"question\":\"What recurrence sites were analyzed in this study?\",\"answer\":\"Recurrence was divided into four groups: lymph node (LN), peritoneum, other single organs, and multiple lesions.\"},{\"question\":\"Did survival after surgery differ between recurrence sites?\",\"answer\":\"Survival after resection did not show a statistically significant difference across recurrence sites.\"},{\"question\":\"Which recurrence sites were associated with worse prognosis after recurrence?\",\"answer\":\"Patients with peritoneal recurrence and multiple lesion recurrences had significantly worse survival after recurrence.\"}]","Prognostic Relevance of Recurrent Sites of Gastric Cancer Treated With Curative Resection - A Single Center Retrospective Study | PDF",1789997283,23]