[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-329826-105":59,"doc-detail-329826-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","prognostic-nomogram-for-verrucous-leukoplakia-proliferative","Prognostic nomogram for verrucous leukoplakia - proliferative","","Proliferative verrucous leukoplakia (PVL) is a distinct leukoplakia subtype with a high malignant transformation rate into oral squamous cell carcinoma (OSCC). This study assesses canceration risk and prognostic factors and builds diagnostic and prognostic predictive nomogram models. A cohort of 467 patients (170 PVL cases) was analyzed using univariable and multivariable logistic regression, with model performance evaluated via ROC, calibration, Hosmer-Lemeshow, and decision curve analyses.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognostic-nomogram-for-verrucous-leukoplakia-proliferative/329826/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognostic-nomogram-for-verrucous-leukoplakia-proliferative/329826.png","ImageObject",300,407,{"name":92,"@type":93},"Aurelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main objective for proliferative verrucous leukoplakia (PVL)?","Question",{"text":112,"@type":113},"To analyze canceration risk and prognostic factors of PVL and establish diagnostic and prognostic predictive nomogram models.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were PVL risk and prognostic factors identified?",{"text":117,"@type":113},"Independent risk and prognostic factors were analyzed using univariable and multivariable logistic regression.",{"name":119,"@type":110,"acceptedAnswer":120},"Which factors were identified as associated with canceration risk and prognosis in PVL?",{"text":121,"@type":113},"Canceration risk factors include sex, lesion sites, clinical presentation, non-smoker status, and oral epithelial dysplasia (OED). Independent prognostic factors include sex, clinical presentation, local irritants, and OED.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},329826,1790363885,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},1099514068365,"https://ap-avatar.wpscdn.com/avatar/10000253d8d9f28188e?_k=1776742907772140068","Journal of Dental Sciences 20 (2025) 238e247  \nAvailable online [at](at www.sciencedirect.com)[ www.sciencedirect.com](at www.sciencedirect.com)  \nScienceDirect  \njournal [homepage:](homepage: www. e-jds. com)[ www. e-jds. com](homepage: www. e-jds. com)  \nOriginal Article  \nPrognostic nomogram for verrucous leukoplakia  \nproliferative  \nYanning Zhang a,b, Xinning Zhang a,c, Zhiming Qin a,c, Jing Yan a, Binbin Li a,c*  \na Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Beijing, PR China  \nb Laboratory of Stomatology Hebei Clinical Research Center for Oral Diseases, School and Hospital of Stomatology, Hebei Medical University, Shijiazhuang, PR China  \nc Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), PR China  \nReceived 3 July 2024; Final revision received 30 July 2024 Available online 13 August 2024  \nKEYWORDS Proliferativeverrucous  \nleukoplakia; Nomogram; Early diagnosis; Prognosis; Predictive model  \nAbstract Background: Proliferative verrucous leukoplakia (PVL) is a special type of leukoplakia characterized by high rate of malignant transformation into oral squamous cell carcinoma (OSCC) . This study aimed to analyze the canceration risk and prognostic factors of PVL and establish effective diagnostic and prognostic predictive models.  \nMaterials and methods: A total of 467 patients were enrolled, including 170 cases of PVL. The independent risk and prognostic factors of PVL were analyzed by univariable and multivariable logistic regression. Nomogram models were constructed to predict the canceration risk and prognosis of PVL. The predictive power was evaluated by HosmereLemeshow test, receiver operating characteristic (ROC) curve, calibration curve and decision curve analysis.  \nResults: Multivariable logistic regression analyses identified that canceration risk factors of PVL included sex, lesion sites, clinical presentation, non-smoker and oral epithelial dysplasia (OED) . The independent prognostic factors of PVL were sex, clinical presentation, local irritants and OED. Diagnosis and prognostic nomogram models were constructed. The areas under the ROC curve were 0.945 and 0.893, respectively. The calibration plots showed strong agreement between the prediction and observation. Decision curve analysis indicated that the models provided significant clinical benefits for patients.  \n* Corresponding author. Department of Oral Pathology, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices, Research Unit of Precision Pathologic Diagnosis in Tumors of the Oral and Maxillofacial Regions, Chinese Academy of Medical Sciences (2019RU034), No. 22 Zhongguancun South Avenue, Haidian District, Beijing, 100081, PR China.  \nE-mail address: [kqlibinbin@bjmu.edu.cn](kqlibinbin@bjmu.edu.cn) (B. Li).  \n[https://doi.org/10.1016/j.jds.2024.07.037](https://doi.org/10.1016/j.jds.2024.07.037)  \n1991-7902/ª 2025Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This isan open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \nConclusion: Our study established and validated the diagnosis and prognostic predictive nomogram models, which were accurate to predict the canceration risk and prognostic factors of PVL, providing individualized clinical decisions for clinical work.  \nª 2025 Association for Dental Sciences of the Republic of China. Publishing services by Elsevier B.V. This is an open access article under the CC BY-NC-ND l","cbCaikKTfQSlL7vE","https://ap.wps.com/l/cbCaikKTfQSlL7vE","pdf",1656573,"English","# Abstract\n## Background\n## Materials and methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the study’s main objective for proliferative verrucous leukoplakia (PVL)?\",\"answer\":\"To analyze canceration risk and prognostic factors of PVL and establish diagnostic and prognostic predictive nomogram models.\"},{\"question\":\"How were PVL risk and prognostic factors identified?\",\"answer\":\"Independent risk and prognostic factors were analyzed using univariable and multivariable logistic regression.\"},{\"question\":\"Which factors were identified as associated with canceration risk and prognosis in PVL?\",\"answer\":\"Canceration risk factors include sex, lesion sites, clinical presentation, non-smoker status, and oral epithelial dysplasia (OED). Independent prognostic factors include sex, clinical presentation, local irritants, and OED.\"}]","Prognostic nomogram for verrucous leukoplakia - proliferative | PDF",1789985733,25]