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Searches in PubMed, Embase, and Cochrane Library were performed through September 2022, and hazard ratios were pooled for overall survival, disease-specific survival, progression-free survival, and disease-free survival.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/prognostic-impact-of-oral-microbiome-on-survival-of-malignancies-a-systematic-review-and-meta-analysis/326758/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/prognostic-impact-of-oral-microbiome-on-survival-of-malignancies-a-systematic-review-and-meta-analysis/326758.png","ImageObject",300,407,{"name":42,"@type":43},"Logic","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What was the goal of this meta-analysis?","Question",{"text":63,"@type":64},"To evaluate the prognostic impact of the oral microbiome on survival outcomes in patients with malignant neoplasms.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which databases and timeframe were searched?",{"text":68,"@type":64},"PubMed, Embase, and Cochrane Library were searched until September 2022.",{"name":70,"@type":61,"acceptedAnswer":71},"What oral microbiome findings were associated with poorer survival?",{"text":72,"@type":64},"Low oral microbiome diversity and Fusobacterium-high/positive or Porphyromonas gingivalis-positive signals in cancer tissue were associated with worse overall survival, and low diversity was also linked with poorer disease-specific survival and progression/disease-free survival.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326758,1790134862,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},7,"Healthcare",40,"healthcare",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":113,"slug":114},8,30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":112,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Li et al. Systematic Reviews (2024) 13:41 [https://doi.org/10.1186/s13643-023-02419-7](https://doi.org/10.1186/s13643-023-02419-7)  \nSystematic Reviews  \n SYSTEMATIC REVIEW UPDATE Open Access  \nPrognostic impact of oral microbiome  \non survival of malignancies: a systematic review and meta-analysis  \nShuluan Li 1†, Tianyu Wang2†, Ya Ren3†, Zhou Liu3*, Jidong Gao2* and Zhi Guo4,5*  \nAbstract  \nBackground Recent studies have shown that there exists a significant correlation between oral microbiome and the occurrence of malignancies. However, the prognostic significance of oral microbiome for cancer patients remains unclear. The purpose of this meta-analysis is to evaluate the impact of oral microbiome on the survival of patients with malignant neoplasms.  \nMethods We conducted a thorough literature search of PubMed, Embase, and Cochrane Library databases until September 2022. The hazard ratio (HR) with a corresponding 95% confidence interval (CI) was analyzed using Review Manager 5.4 software for survival outcomes, including overall survival (OS), disease-specific survival (DSS), progression-free survival (PFS), and disease-free survival (DFS) .  \nResults A total of 15 studies, covering 5191 samples with various types of cancers, were selected based on specified inclusion and exclusion criteria. In both univariate and multivariate analysis, patients with low diversity of the oral microbiome, or those with Fusobacterium-high/positive, or P. gingivalis positive in cancer tissue displayed poorer OS (univariate HR = 1 . 74; 95% CI 1.15–2. 62; P = 0 . 009; multivariate HR = 1 . 56; 95% CI 1.07–2. 27; P = 0 . 02), DSS (univariate HR = 2 . 06; 95% CI 1.50–2. 84; P \u003C 0. 00001; multivariate HR = 1 . 80; 95% CI 1.48–2. 20; P \u003C 0. 00001), and PFS/DFS (univariate HR = 2 . 00; 95% CI 1.12–3. 58; P = 0 . 002; multivariate HR = 1 . 78; 95% CI 1.05–3. 02; P = 0 . 003) . Subgroup analysis revealed that Fusobacterium positive or high abundance in cancer tissues was associated with poor OS in multivariate analysis but had no statistical differences in PFS or DFS in univariate and multivariate analysis. Additionally, P. gingivalis positive in cancer tissue was also associated with worse OS.  \nConclusions Our meta-analysis suggests that the composition of the oral microbiome may play a significant role in predicting survival outcomes for cancer patients.  \nKeywords Oral microbiome, Malignancies, Survival, Meta-analysis  \n†Shuluan Li, Tianyu Wang andYa Ren contributed equally to this work.  \n*Correspondence: Zhou Liu [443617072@qq.com](443617072@qq.com)[ ](443617072@qq.com)Jidong Gao [ab168@cicams.ac.cn](ab168@cicams.ac.cn)[ ](ab168@cicams.ac.cn)Zhi Guo [guozhi77@126.com](guozhi77@126.com)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[. The Creative Commons Public Domain Dedication waiver (](http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ()[http://creativeco](http://creativeco)[mmons.org/publicdomain/zero/1.0/](mmon","cbCaioM8r9WRmsJz","https://ap.wps.com/l/cbCaioM8r9WRmsJz","pdf",3392578,11,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions\n# Keywords","[{\"question\":\"What was the goal of this meta-analysis?\",\"answer\":\"To evaluate the prognostic impact of the oral microbiome on survival outcomes in patients with malignant neoplasms.\"},{\"question\":\"Which databases and timeframe were searched?\",\"answer\":\"PubMed, Embase, and Cochrane Library were searched until September 2022.\"},{\"question\":\"What oral microbiome findings were associated with poorer survival?\",\"answer\":\"Low oral microbiome diversity and Fusobacterium-high/positive or Porphyromonas gingivalis-positive signals in cancer tissue were associated with worse overall survival, and low diversity was also linked with poorer disease-specific survival and progression/disease-free survival.\"}]","Prognostic impact of oral microbiome on survival of malignancies - a systematic review and meta-analysis | PDF",1789975262,28]