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Low mitotic rate independently reduced mortality, while pleomorphism strongly increased mortality, emphasizing the prognostic value of detailed histopathological 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Makale  \nPrognostic clinical and pathological factors in intrathoracic solitary fibrous tumors: A retrospective single-center study  \nİntratorasik soliter fibröz tümörlerde prog nostik klinik ve patolojik faktörler: Retrospektif tek merkezli çalışma  \nAylin Canavar􀀬, Melek Erk􀀬, Levent Cansever􀀬, Kemal Karapınar􀀬, Emir Kaan Tekin􀀬,  \nVolkan Erdoğu􀀬, Muzaffer Metin􀀬  \nDepartment of Chest Surgery, Yedikule Chest Diseases and Thoracic Surgery Training and Research Hospital, İstanbul, Türkiye  \nABSTRACT  \nBackground: This study aims to emphasize the features that should be considered in the follow-up of patients with solitary fibrous tumors by analyzing the clinical and pathological parameters that are effective in the prognosis.  \nMethods: In this study, 53 patients (28 males, 25 females; mean age: 56.2±5 years; range, 24 to 76 years) diagnosed with solitary fibrous tumor and operated on between 2009 and 2023 were retrospectively examined. The patients included in the study were followed for at least one year. Patients with complete clinical and pathological data records were included in the study. Survival and recurrence rates were analyzed in relation to clinical and pathological parameters.  \nResults: The median follow-up was 44.9 months. Eight (15%) patients underwent anatomic resection, 23 (35.8%) patients underwent wedge resection, five (5.6%) patients underwent total pleurectomy, 26 (41.5%) patients underwent mass excision, and three (1.8%) underwent mass excision and chest wall resection. Survival analyses were conducted using the Kaplan-Meier method. Overall survival and disease-free survival were calculated in months from the date of surgery until the date of death or recurrence, respectively. Low mitotic rate was found to be a significant independent predictor of reduced mortality (odds ratio [OR]=0.46, 95% confidence interval [CI]: 0.243-0.877, p=0.018), indicating better survival outcomes in patients with low mitotic activity. In contrast, low Ki-67 expression was not a statistically significant predictor (OR=0.9, 95% CI: 0.880-1.116, p=0.885) . Pleomorphism was strongly associated with increased mortality (OR=10.0, 95% CI: 1.316–76.081, p=0.026), highlighting the importance of pleomorphism as an important prognostic marker. Necrosis, although not statistically significant (OR=6.3, 95% CI: 0.497-79,123, p=0.156), showed a trend indicating worse outcomes. Similarly, CD34 negativity showed a trend in favor of mortality (OR=3.5, 95% CI: 0.429-28.990, p=0.241 .  \nConclusion: Solitary fibrous tumors are generally benign and have low recurrence and high survival rates. However, the recurrence rate is higher in malignant solitary fibrous tumors. According to the results of our study, high mitosis rate and pleomorphism are important independent predictors of increased mortality in solitary fibrous tumors. These findings emphasize the importance of detailed histopathological examination in prognostic evaluation.  \nKeywords: Mitotic count, pleomorphism, prognostic factors, solitary fibrous tumor, survival, recurrence.  \nÖZ  \nAmaç: Bu çalışmada, soliter fibröz tümörlü hastaların prognozunda etkili olan klinik ve patolojik parametreler analiz edilerek bu hastalarıntakibinde dikkate alınması gereken özellikler vurgulandı .  \nÇalışma planı: Bu çalışmada 2009-2023 yılları arasında soliter fibröz tümör tanısı konulan ve ameliyat edilen 53 hasta (28 erkek, 25 kadın; ort. yaş: 56.2±5 yıl; dağılım, 24-76 yıl) retrospektif olarak incelendi.Çalışmaya dahil edilen hastalar en az bir yıl takip edildi. Klinik ve patolojik veri kayıtları tam olan hastalar çalışmaya dahil edildi. Sağkalım ve nüks oranları klinik ve patolojik parametrelerle ilişkili olarak analiz edildi.  \nBulgular: Medyan takip süresi 44.9 aydı . Hastaların sekizi (%15) anatomik rezeksiyon, 23ʼü (%35.8) kama rezeksiyonu, beşi (%5.6) total plörektomi, 26ʼsı (%41.5) kitle eksizy","cbCait2SJxBkChbn","https://ap.wps.com/l/cbCait2SJxBkChbn","pdf",699002,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n## Keywords","[{\"question\":\"What was the aim of the study on intrathoracic solitary fibrous tumors?\",\"answer\":\"To identify clinical and pathological features relevant to prognosis by analyzing parameters effective in follow-up outcomes.\"},{\"question\":\"How were survival outcomes analyzed in this retrospective study?\",\"answer\":\"Survival analyses used the Kaplan-Meier method, calculating overall survival and disease-free survival in months from surgery to death or recurrence.\"},{\"question\":\"Which pathological factors were associated with mortality in the results?\",\"answer\":\"Low mitotic rate was an independent predictor of reduced mortality, while pleomorphism was strongly associated with increased mortality.\"}]","Prognostic clinical and pathological factors in intrathoracic solitary fibrous tumors: A retrospective single-center study | PDF",1790712315,23]