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This retrospective study compared segmentectomy versus lobectomy in 888 patients with clinical T1c solid-dominant NSCLC (tumor diameter 2–3 cm; consolidation-to-tumor ratio >0.5). Five-year recurrence-free survival (RFS) and overall survival (OS) were assessed using propensity score matching (1:1) and subgroup Cox regression. Segmentectomy showed higher 5-year OS and RFS, with OS significant overall.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prognosis-of-segmentectomy-and-lobectomy-for-clinical-t1c-solid-dominant-lung-cancer/448167/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prognosis-of-segmentectomy-and-lobectomy-for-clinical-t1c-solid-dominant-lung-cancer/448167.png","ImageObject",300,407,{"name":92,"@type":93},"Ezra","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What clinical population was included in this study?","Question",{"text":113,"@type":114},"Patients with clinical T1c solid-dominant NSCLC were included, with tumor diameter 2–3 cm and consolidation-to-tumor ratio greater than 0.5.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which treatment strategies were compared?",{"text":118,"@type":114},"The study compared segmentectomy of the dominant pulmonary segment with lobectomy for clinical T1c solid-dominant NSCLC.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings for overall survival and recurrence-free survival?",{"text":122,"@type":114},"Segmentectomy showed a statistically significant improvement in 5-year overall survival versus lobectomy in the overall analysis. Five-year recurrence-free survival was also higher for segmentectomy, though the propensity score analysis did not show a significant difference.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},448167,1790956200,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1099514068035,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Prognosis of segmentectomy and lobectomy for clinical T1c solid-dominant lung cancer  \nZiyao Zhang1,2,3\\#, Fangqiu Fu1,2,3\\#, Xiangze Li1,2,3\\#, Yang Zhang1,2,3, Haiquan Chen1,2,3  \n1Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, Shanghai, China; 2Institute of Thoracic Oncology, Fudan University, Shanghai, China; 3Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China  \nContributions: (I) Conception and design: Z Zhang, Y Zhang, H Chen; (II) Administrative support: Y Zhang, H Chen; (III) Provision of study materials or patients: Z Zhang, F Fu, X Li; (IV) Collection and assembly of data: Z Zhang, X Li; (V) Data analysis and interpretation: Z Zhang, Y Zhang; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work.  \nCorrespondence to: Haiquan Chen, MD; Yang Zhang, MD. Department of Thoracic Surgery and State Key Laboratory of Genetic Engineering, Fudan University Shanghai Cancer Center, 270 Dong’an Road, Shanghai 200032, China; Institute of Thoracic Oncology, Fudan University, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, [China. Email: hqchen1@yahoo.com](China. Email: hqchen1@yahoo.com); [fduzhangyang1987@hotmail.com](fduzhangyang1987@hotmail.com).  \nBackground: The optimal surgical extent for clinical T1c solid-dominant non-small cell lung cancer (NSCLC) remains debated. This study aimed to compare the recurrence-free survival (RFS) and overall survival (OS) between segmentectomy and lobectomy in patients with clinical T1c solid-dominant NSCLC.  \nMethods: We retrospectively analyzed 888 patients with clinical T1c solid-dominant NSCLC [tumor  \ndiameter: 2–3 cm; consolidation-to-tumor ratio (CTR) >0.5] who underwent segmentectomy of the dominant pulmonary segment or lobectomy. Clinical characteristics, 5-year RFS, and 5-year OS were evaluated. Propensity score matching (PSM, 1:1) and subgroup Cox regression models were employed to  \nadjust for confounders.  \nResults: Of the 888 eligible cases, segmentectomy and lobectomy were performed in 55 and 833 patients, respectively. The difference in the 5-year OS between segmentectomy and lobectomy was found to be statistically significant (91.7% vs. 84.3%, P=0.02), which was also showed in the propensity score analysis (91.7% vs. 90.0%; P=0.08), with a median follow-up time of 46 months. The 5-year RFS did differ significantly between segmentectomy and lobectomy (89.46% vs. 71.50%; P=0.02), but it shown no  \ndifference in the propensity score analysis (89.46% vs. 81.5%; P=0.26) .  \nConclusions: The results indicate that segmentectomy of dominant pulmonary segment is superior to  \nlobectomy in terms ofOS for solid-dominant NSCLC cases with a tumor diameter between 2 and 3 cm.  \nKeywords: Segmentectomy; lobectomy; solid-dominant; clinical T1c; lung cancer  \nSubmitted Sep 15, 2025. Accepted for publication Nov 10, 2025. Published online Dec 29, 2025.  \ndoi: 10.21037/tlcr-2025-1068  \nView this article at: [https://dx.doi.org/10.21037/tlcr-2025-1068](https://dx.doi.org/10.21037/tlcr-2025-1068)  \nIntroduction  \nThe cornerstone of treatment for early-stage non-small cell lung cancer (NSCLC) remains radical lobectomy, a procedure involving en bloc resection of the affected pulmonary lobe, ipsilateral hilar lymph nodes, and mediastinal lymph node dissection to ensure oncological radicality. In 1995, Ginsberg and Rubinstein conducted a  \nrandomized controlled clinical trial comparing lobectomy to local resection for early stage lung cancer with nodules ≤ 3 cm in diameter (1) . Although the study established lobectomy as a superior radical treatment, it was unable to demonstrate the non-inferiority of sublobectomy due to limitations in case enrollment criteria and surgical instruments available at that time.  \n© AME Publishing Company. Transl Lung Cancer Res 2025;14(1","cbCaivQdf5eqnQ7Y","https://ap.wps.com/l/cbCaivQdf5eqnQ7Y","pdf",764814,"English","# Introduction\n## Background and rationale\n# Methods\n## Study design and patient selection\n## Survival endpoints and statistical analysis\n# Results\n## Overall survival\n## Recurrence-free survival\n# Conclusions\n## Clinical implications","[{\"question\":\"What clinical population was included in this study?\",\"answer\":\"Patients with clinical T1c solid-dominant NSCLC were included, with tumor diameter 2–3 cm and consolidation-to-tumor ratio greater than 0.5.\"},{\"question\":\"Which treatment strategies were compared?\",\"answer\":\"The study compared segmentectomy of the dominant pulmonary segment with lobectomy for clinical T1c solid-dominant NSCLC.\"},{\"question\":\"What were the main findings for overall survival and recurrence-free survival?\",\"answer\":\"Segmentectomy showed a statistically significant improvement in 5-year overall survival versus lobectomy in the overall analysis. Five-year recurrence-free survival was also higher for segmentectomy, though the propensity score analysis did not show a significant difference.\"}]","Prognosis of segmentectomy and lobectomy for clinical T1c solid-dominant lung cancer | PDF",1790725814,25]