[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-290134-105":59,"doc-detail-290134-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","profilegraph-an-interactive-graphical-tool-for-protein-sequence-analysis","PROFILEGRAPH - an interactive graphical tool for protein sequence analysis","","PROFILEGRAPH is a computer program designed for interactive, graphical analysis of amino acid sequences. It integrates multiple sliding-window methods into a single user-friendly interface, letting users combine amino-acid specific parameters with selectable analysis types and visualize results as graphs in several on-screen windows. It also supports calculating amino-acid specific parameter moments for given secondary structures, reporting absolute moment values and moment angles relative to a reference residue, and includes utilities such as helical-wheel diagrams for protein primary-structure inspection.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":30,"@type":76,"position":81},"https://docshare.wps.com/document/technology/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/profilegraph-an-interactive-graphical-tool-for-protein-sequence-analysis/290134/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/profilegraph-an-interactive-graphical-tool-for-protein-sequence-analysis/290134.png","ImageObject",300,407,{"name":92,"@type":93},"Mimi","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-06","2026-09-17",true,{"@type":102,"interactionType":103,"userInteractionCount":24},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is PROFILEGRAPH used for?","Question",{"text":112,"@type":113},"PROFILEGRAPH is used to analyze amino acid sequences graphically, integrating sliding-window methods to compute and display amino-acid property profiles.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What inputs are needed for sliding-window profile calculation?",{"text":117,"@type":113},"The calculation uses the amino acid sequence, a table of amino-acid specific parameter values, and the sliding window width used for averaging.",{"name":119,"@type":110,"acceptedAnswer":120},"How does PROFILEGRAPH support analysis beyond simple averaging?",{"text":121,"@type":113},"It can compute distributions of amino-acid property along proposed secondary structures and calculate hydrophobic moments or averaged hydropathy on specific helical faces.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},290134,1790618727,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":29,"category_name":30,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":24,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},2336477974920,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","K.Hofmann and W.Stoffel  \n# Abstract\n\nThe computer program PROFILEGRAPH,a graphical inter-active tool for the analysis of amino acid sequences,isdescribed.The main task of the program is to integrate a varietyof sliding-window methods into a single user-friendly shell.Theprogram allows the user to combine any amino acid specificparameter with a selection of several possible types of analysisand to plot the resulting graph in one of several windows onthe screen.It is also possible to calculate the moment of theamino acid specific parameter for a given secondary structureand to display both the absolute moment value and the momentangle relative to a reference residue.Also included are severaluilities that facilitate visual analysis of protein primarystructures like,for example,helical-wheel diagrams.It spossible to adapt the majority of published sliding-windowanalysis procedures for use with PROFILEGRAPH.  \n# Introduction\n\nOne o the most frequently encountered tasks in the computer-assisted analysis of amino acid sequences is a graphicalrepresentation of the distribution of some amino acid propertiesalong the primary structure.A well-known example for thistype of analysis is the hydropathy plot(Kyte and Doolittle,1982).  \nThe general procedure for the calculation of a sliding-windowprofile requires as input (i)the amino acid sequence;(ii)a tableof the amino acid specific parameter to be analyzed,holdinga numerical value for each different amino acid;and(iii)thewidth of the window that is used for averaging.In the first stepof the calculation,for each residue in the original sequence anabscissa value is given by the position of the residue,while theordinate is the parameter value associated with the amino acidunder consideration.In most cases,a plot at this stage of theanalysis would be too noisy to be useful,so the ordinate valueof a specified position i is usually not only a function of theamino acid A but an average of a window centered around theconsidered position including also values for the neighboring  \nInstitute fur Biochemie,Medizinische Fakulrdt der Universitat zu Kon,JosephSrelzmann Strasse 52,D-5000 Koln 41,Gernany  \nINTERNET:KHOFMANN@BIOMED.BIOLAN.UNI-KOELN.DE'To whom reprint request should be sent  \n# PROFILEGRAPH:an interactive graphical toolfor protein sequence analysis\n\namino acids A;-n·…,Ai-1,A;,A₁+1,…,Ai+nif the windowwidth is 2n+1.  \nMany different sets of amino acid parameters have beenproposed for sliding-window analysis of protein sequences,among them different measures for amino acid hydrophobicity(Ponnuswany et al.,1980;Hopp and Woods,1981;Kyte andDoolittle,1982;Eisenberg,1984;Parker et al.,1986).Otherexamples are measures for flexibility(Karplus and Schulz,1985;Bhaskaran and Ponnuswamy,1988;Ragone et al.,1989),residue volume(Chothia,1975),surface area(Rose et al.,1985)and propensity for different secondary structure types (Levitt,1978).A database of all published amino acid parameters has'been compiled and is being updated (Nakai et al.,1988).  \nMost of these amino acid parameters are used with only onerecommended window width while in some cases the windowwidth has to be adjusted depending on the type of informationto be obtained.As an example,the hydrophobicity parameterswhen used with a window width of～17-19 give informationabout possible transmembranal domains of proteins,while forlocating smaller hydrophobic stretches,as they occur withinthe core of globular proteins,window widths of～7 are usuallyapplied.  \nBesides these simple average calculations of a single aminoacid parameter,some more complex types of analysis also basedon profile calculation have been proposed.Some of these arefor determining the distribution of a particular amino acidproperty along a proposed secondary structure.An example isthe calculation of the hydrophobic moment (Eisenberg et al.,1982)as a measure of the excentricity of hydrophobicity ifconsidering an α-helix.Another method in dealing withasymmetrical hydrophobicities ","cbCaicqeNArDQrBX","https://ap.wps.com/l/cbCaicqeNArDQrBX","pdf",9835775,"English","# Abstract\n# Introduction\n# PROFILEGRAPH: an interactive graphical tool for protein sequence analysis","[{\"question\":\"What is PROFILEGRAPH used for?\",\"answer\":\"PROFILEGRAPH is used to analyze amino acid sequences graphically, integrating sliding-window methods to compute and display amino-acid property profiles.\"},{\"question\":\"What inputs are needed for sliding-window profile calculation?\",\"answer\":\"The calculation uses the amino acid sequence, a table of amino-acid specific parameter values, and the sliding window width used for averaging.\"},{\"question\":\"How does PROFILEGRAPH support analysis beyond simple averaging?\",\"answer\":\"It can compute distributions of amino-acid property along proposed secondary structures and calculate hydrophobic moments or averaged hydropathy on specific helical faces.\"}]","PROFILEGRAPH - an interactive graphical tool for protein sequence analysis | PDF",1789640743,18]