[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-369606-105":59,"doc-detail-369606-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","probiotics-and-cancer-mechanistic-insights-and-organ-specific-impact","Probiotics and Cancer: Mechanistic Insights and Organ-Specific Impact","","Probiotics modulate the gut microbiome and influence multiple cancer types, including oesophageal, lung, liver, and colorectal cancer. Reported mechanisms cover inhibition of carcinogen metabolism, anti-inflammatory and immunopotentiator effects, antioxidant activity, suppression of tumour growth, and reduction of chemotherapy-related adverse effects. The review synthesizes recent findings on probiotic efficacy for prevention and treatment and highlights organ-specific impact. Strategic probiotic use is suggested as a complementary cancer management approach, while further studies and clinical trials are needed.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/probiotics-and-cancer-mechanistic-insights-and-organ-specific-impact/369606/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/probiotics-and-cancer-mechanistic-insights-and-organ-specific-impact/369606.png","ImageObject",300,407,{"name":92,"@type":93},"Bintang","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How do probiotics affect cancer according to the review?","Question",{"text":113,"@type":114},"The review states that probiotics can modulate the gut microbiome, prevent metabolism of carcinogenic substances, exert anti-inflammatory and immunopotentiator effects, and show antioxidant activity. It also notes potential to prevent tumour growth and decrease chemotherapy-induced side effects.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which cancer types are mentioned as having probiotic-related impact?",{"text":118,"@type":114},"The abstract lists oesophageal, lung, liver, and colorectal cancer. It also refers to multiple kinds of cancer as potential targets for complementary probiotic management.",{"name":120,"@type":111,"acceptedAnswer":121},"Is probiotic use recommended as a standalone cancer treatment?",{"text":122,"@type":114},"No. The evidence is framed as a complementary approach for management, and the review emphasizes that additional studies and clinical trials are required to better understand relationships between cancer and probiotics.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},369606,1790318518,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146},962085564381,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Review  \nProbiotics and Cancer: Mechanistic Insights and Organ-Specific Impact  \nMd Faruque Ahmad 1, *, Fakhruddin Ali Ahmad 2, Abdulrahman A. Alsayegh 1, Md. Zeyaullah 3,  \nAhmad O. Babalghith 4, Hani Faidah 5, Faiyaz Ahmed 6, Anjum Khanam 1, Boshra Mozaffar 1, Nahla Kambal 1 and Farkad Bantun 5  \nAcademic Editor: Wei Zhong  \nReceived: 17 April 2025  \nRevised: 6 June 2025  \nAccepted: 13 June 2025  \nPublished: 16 June 2025  \nCitation: Ahmad, M.F.; Ahmad, F.A.; Alsayegh, A.A.; Zeyaullah, M.; Babalghith, A.O.; Faidah, H.; Ahmed, F.; Khanam, A.; Mozaffar, B.; Kambal, N.; et al. Probiotics and Cancer: Mechanistic Insights and OrganSpecific Impact. Biomolecules 2025, 15, 879. [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)biom15060879  \nCopyright: © 2025 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://creativecommons.org/](https://creativecommons.org/)[ ](https://creativecommons.org/)[licenses/by/4.0/](licenses/by/4.0/)) .  \n1 Department of Clinical Nutrition, College of Nursing and Health Sciences, Jazan University, Jazan 45142, Saudi Arabia; [aalsayegh@jazanu.edu.sa](aalsayegh@jazanu.edu.sa) (A.A.A.); [akhanam@jazanu.edu.sa](akhanam@jazanu.edu.sa) (A.K.); [bmozaffar@jazanu.edu.sa](bmozaffar@jazanu.edu.sa) (B.M.); [nhmohammed@jazanu.edu.sa](nhmohammed@jazanu.edu.sa) (N.K.)  \n2 Department of Basic and Applied Science, School of Engineering and Science, G.D Goenka University, Gurugram 122103, Haryana, India; [faahmad97@gmail.com](faahmad97@gmail.com)  \n3 Department of Basic Medical Science, College of Applied Medical Sciences, Khamis Mushayt Campus, King Khalid University (KKU), Abha 62561, Saudi Arabia; [mdhafed@kku.edu.sa](mdhafed@kku.edu.sa)  \n[4](4 Department of Medical Genetics)[ Department of Medical Genetics](4 Department of Medical Genetics), [Faculty of Medicine](Faculty of Medicine), [Umm Al-Qura University](Umm Al-Qura University), Makkah 24382, Saudi Arabia; [aobabalghith@uqu.edu.sa](aobabalghith@uqu.edu.sa)  \n5 Department of Microbiology and Parasitology, Faculty of Medicine, Umm Al-Qura University, Makkah 24382, Saudi Arabia; [hsfaidah@uqu.edu.sa](hsfaidah@uqu.edu.sa) (H.F.); [fmbantun@uqu.edu.sa](fmbantun@uqu.edu.sa) (F.B.)  \n6 Department of Basic Health Sciences, College of Applied Medical Sciences, Qassim University, Buraydah 51452, Saudi Arabia; [f.masfoor@qu.edu.sa](f.masfoor@qu.edu.sa)  \n* [Correspondence: mfahmd@gmail.com or mfahmad@jazanu.edu.sa](Correspondence: mfahmd@gmail.com or mfahmad@jazanu.edu.sa)  \nAbstract: Probiotics have been revealed in various studies to modulate the gut microbiome and have a substantial impact on cancers, comprising oesophageal, lung, liver, and colorectal cancer. These properties are endorsed by a diverse mechanism, including the modulation of the gut microbiome; preventing the metabolism of carcinogenic substances; exertion of anti-inflammatory action, immunopotentiator properties, and antioxidant activities; prevention of tumour growth; and decreasing the adverse effects of chemotherapy. There are promising perspectives regarding the new and developing field of probiotic research in relation to cancer treatment. This review demonstrates the recent findings of probiotics efficacy in cancer prevention and treatment and organ-specific impact along with protection from chemotherapy-induced side effects. The present evidence specifies that strategic probiotics application may be an effective complementary approach for the management of numerous kinds of cancer; still, additional studies and clinical trials are required to comprehend the relationships between cancer and probiotics.  \nKeywords: probiotics in cancer; mechanisms; safety; chemotherapy; synergistic; antioxidant  \n1. Introduction  \nCancer is a complicated group of disorders characterised by aberrant cell proliferation, which can have lethal effe","cbCairwj8t426HqH","https://ap.wps.com/l/cbCairwj8t426HqH","pdf",4179756,37,"English","# Introduction\n# Cancer Overview\n# Probiotics and Gut Microbiome\n# Lactobacillus and Taxonomic Updates\n# Review Scope and Mechanisms","[{\"question\":\"How do probiotics affect cancer according to the review?\",\"answer\":\"The review states that probiotics can modulate the gut microbiome, prevent metabolism of carcinogenic substances, exert anti-inflammatory and immunopotentiator effects, and show antioxidant activity. It also notes potential to prevent tumour growth and decrease chemotherapy-induced side effects.\"},{\"question\":\"Which cancer types are mentioned as having probiotic-related impact?\",\"answer\":\"The abstract lists oesophageal, lung, liver, and colorectal cancer. It also refers to multiple kinds of cancer as potential targets for complementary probiotic management.\"},{\"question\":\"Is probiotic use recommended as a standalone cancer treatment?\",\"answer\":\"No. The evidence is framed as a complementary approach for management, and the review emphasizes that additional studies and clinical trials are required to better understand relationships between cancer and probiotics.\"}]","Probiotics and Cancer: Mechanistic Insights and Organ-Specific Impact | PDF",1790183665,93]