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This retrospective observational study evaluated the impact of proactive consultation of laboratory medicine (PCLM) on diagnostic performance and clinical outcomes in newly diagnosed patients from 2011 to 2022. PCLM started in 2015 using a laboratory-oriented algorithm. After implementation, the annual diagnostic rate increased from 4.65 ± 1.59 to 7.43 ± 1.52 per million patient-visits, and the median interval from symptom onset to diagnosis shortened significantly (50 days vs 150 days, P=.003). One-year survival was higher after PCLM (72.4% vs 51.7%, P=.035).",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/proactive-consultation-of-laboratory-medicine-increased-diagnostic-rate-of-multiple-myeloma-one-single-centers-12-year-experience/342887/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/proactive-consultation-of-laboratory-medicine-increased-diagnostic-rate-of-multiple-myeloma-one-single-centers-12-year-experience/342887.png","ImageObject",300,407,{"name":92,"@type":93},"Violet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problem does proactive consultation of laboratory medicine (PCLM) address in multiple myeloma?","Question",{"text":112,"@type":113},"PCLM targets diagnostic delay caused by the disease’s rarity and nonspecific symptoms, helping support more timely diagnosis.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How did PCLM affect the diagnostic rate after implementation?",{"text":117,"@type":113},"The annual diagnostic rate increased from 4.65 ± 1.59 to 7.43 ± 1.52 per million patient-visits after PCLM was implemented.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the outcome improvements linked to PCLM in this study?",{"text":121,"@type":113},"PCLM significantly shortened the median time from symptom onset to diagnosis and improved one-year survival compared with the pre-implementation period.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},342887,1790195112,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","®  \n Observational Study   \nProactive consultation of laboratory medicine increased diagnostic rate of multiple myeloma One single center’s 12-year experience  \nChih-Chun Chang, MDa ,b , Jung-Li Ho, MTa , Pei-Chin Lin, MDa , Chao-Pei Lin, MTa , Wei-Ting Tsai, MTa , Huei-Ling Huang, MTa , Yuan-Bin Yu, MDc ,d ,e , Wei-Chi Chen, MSb ,f , Fang-Yeh Chu, MDa ,g ,h ,*  \n\n| Abstract\u003Cbr>Multiple myeloma (MM) was one of the hardest cancers to diagnose because of numerous nonspecific symptoms, leading to diagnostic delay. Proactive consultation of laboratory medicine (PCLM) could help timely diagnosis of blood cancers, avoiding diagnostic delay. This study aimed to evaluate the effect of PCLM on diagnosis and outcomes in MM. This retrospective study was conducted in newly diagnosed MM patients from 2011 to 2022. Implementation of PCLM initiated in 2015 with a laboratoryoriented algorithm. The annual diagnostic rate, patient demographics, the time intervals from symptom onset to diagnosis and to treatment, and clinical outcomes were analyzed. A total of 134 patients were newly diagnosed during the study interval. The diagnostic rate increased from 4.65 ± 1.59 to 7.43 ± 1.52 per million patient-visits after implementation of PCLM. The median time interval from symptom onset to diagnosis was significantly shortened after implementation of PCLM (50 days with interquartile range [IQR]: 24–136 days vs 150 days with IQR: 41–385 days, P = .003) . Besides, the 1-year survival was significantly higher in patients diagnosed as MM after implementation of PCLM (72 .4% vs 51.7%, P = .035) . Implementation of PCLM not only increased diagnostic rate of MM and improved outcomes, but also raise awareness for MM and promote multidisciplinary collaboration in healthcare. |\n| --- |\n| Abbreviations: COVID-19 = coronavirus disease-19 , FEMH = Far Eastern Memorial Hospital , Ig = immunoglobulin, IQR = interquartile range, ISS = international staging system, MM = multiple myeloma, PCLM = proactive consultation of laboratory medicine. |\n| Keywords: immunoparesis, interval from symptom onset to diagnosis, multiple myeloma, proactive consultation of laboratory medicine, rouleaux formation |\n\n1. Introduction  \nFor decades, multiple myeloma (MM) has been considered as one of the hardest malignancies for diagnosis. The entire rarity and nonspecific symptoms of MM make it difficult to suspect this disease at the first time, hence leading to a diagnostic delay. In the UK, the proportion of MM was about 2% in newly diagnosed cancer patients every year.[1] In Taiwan, it was reported that MM accounted for approximately 0.6% of total new cases diagnosed as cancer.[2] Patients with MM could present with  \nC-CC and J-LH have contributed to this study equally.  \nThe authors have no funding and conflicts of interest to disclose.  \nThe datasets generated during and/or analyzed during the current study are not publicly available, but are available from the corresponding author on reasonable request.  \nThe study was approved by the Ethics Committee of Far Eastern Memorial Hospital (approval date: December 28, 2023 and approval number: 112228-E). The requirement for written informed consent was waived due to the retrospective nature of the study and the use of de-identified data. All procedures used in this study adhere to the tenets of the Declaration of Helsinki. a Department of Clinical Pathology, Far Eastern Memorial Hospital, New Taipei, Taiwan, b Department of Nursing, Cardinal Tien Junior College of Healthcare and Management, Yilan, Taiwan, c Department of Internal Medicine, Division of Oncology and Hematology, Far Eastern Memorial Hospital, New Taipei, Taiwan, d Faculty of Medicine, School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, e Graduate Institute of Medicine, Yuan Ze University, Taoyuan, Taiwan, f Public Health Bureau, New Taipei, Taiwan, g Graduate School of Biotechnology and Bioengineering, Yuan Ze University, Taoyuan, Taiwan,  \nnonspecif","cbCainop7b6hjCaj","https://ap.wps.com/l/cbCainop7b6hjCaj","pdf",677367,"English","# Abstract\n# Introduction\n## Background on diagnostic delay in multiple myeloma\n## Rationale for proactive consultation of laboratory medicine","[{\"question\":\"What problem does proactive consultation of laboratory medicine (PCLM) address in multiple myeloma?\",\"answer\":\"PCLM targets diagnostic delay caused by the disease’s rarity and nonspecific symptoms, helping support more timely diagnosis.\"},{\"question\":\"How did PCLM affect the diagnostic rate after implementation?\",\"answer\":\"The annual diagnostic rate increased from 4.65 ± 1.59 to 7.43 ± 1.52 per million patient-visits after PCLM was implemented.\"},{\"question\":\"What were the outcome improvements linked to PCLM in this study?\",\"answer\":\"PCLM significantly shortened the median time from symptom onset to diagnosis and improved one-year survival compared with the pre-implementation period.\"}]","Proactive consultation of laboratory medicine increased diagnostic rate of multiple myeloma - One single center’s 12-year experience | PDF",1790048641,13]