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When this program fails, inflammation can persist and transition into chronic pathological states, driving cardiovascular disease, metabolic disorders, autoimmune conditions, neurodegeneration, and tumor progression. Conventional anti-inflammatory drugs suppress mediators but do not restore immune balance or actively promote resolution, and long-term use may impair host defense. Pro-resolving lipid mediators (resolvins, maresins, protectins, lipoxins) regulate resolution via efferocytosis enhancement, cytokine modulation, leukocyte trafficking, and receptor-dependent signaling, with remaining challenges in translation such as metabolic inactivation and delivery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/pro-resolving-lipid-mediators-in-diseases-exploring-the-molecular-basis-and-clinical-implication/438848/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/pro-resolving-lipid-mediators-in-diseases-exploring-the-molecular-basis-and-clinical-implication/438848.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-02","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"为什么炎症的消退被认为是“主动”过程？","Question",{"text":112,"@type":113},"炎症消退被理解为由机体协调的程序性生物过程，而不是炎症信号的被动衰减。该程序失败时，炎症可能持续并发展为慢性病理状态。","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"PRLMs 与传统抗炎药物的关键区别是什么？",{"text":117,"@type":113},"传统抗炎药可抑制炎症介质，但不能恢复免疫平衡，也不主动促进消退；长期用药还可能影响宿主防御与组织修复。PRLMs 则通过参与专门的促消退程序来调节免疫稳态。",{"name":119,"@type":110,"acceptedAnswer":120},"PRLMs 主要通过哪些机制发挥促消退作用？",{"text":121,"@type":113},"PRLMs 可通过受体依赖的信号通路作用，增强吞噬/清除（如促巨噬细胞吞噬与清除炎症细胞），调控细胞因子网络，并指导白细胞迁移，同时促进组织再生。","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},438848,1790904648,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Li et al. Molecular Biomedicine (2026) 7:1 [https://doi.org/10.1186/s43556-025-00400-5](https://doi.org/10.1186/s43556-025-00400-5)  \nMolecular Biomedicine  \n REVIEW Open Access  \nPro-resolving lipid mediators in diseases: exploring the molecular basis and clinical implication  \nChaofu Li1†, Zimu Wang2†, Yukun Yang3†, Qiuyan Jiang1, Yingying Jiang1, Jun Xiao1*, Li Shen2,4*, Wei Wu1* and Chuanwei Li 1*  \nAbstract  \nInflammation resolution is now understood as an active and highly coordinated biological process rather than a passive decline in inflammatory signals. When this program fails, inflammation may become persistent and gradually shift to a chronic pathological state. Such unresolved inflammation is increasingly recognized as a core driver of cardiovascular disease, metabolic disorders, autoimmune pathologies, neurodegeneration, and tumor progression. Although conventional anti-inflammatory drugs can suppress inflammatory mediators, they do not restore immune balance or actively promote resolution, and long-term administration may disrupt host defense and tissue-repair processes. Pro-resolving lipid mediators (PRLMs), including resolvins, maresins, protectins, and lipoxins, represent a distinct class of bioactive metabolites derived from polyunsaturated fatty acids. Recent studies have demonstrated that PRLMs regulate inflammation through specialized pro-resolving programs, such as enhancing efferocytosis, modulating cytokine networks, guiding leukocyte trafficking, and promoting tissue regeneration via receptor-dependent signaling pathways. These findings highlight a conceptual shift in inflammation management from broadly inhibiting inflammation to restoring immune homeostasis. Despite encouraging progress, several challenges hinder clinical translation, including rapid metabolic inactivation, limited delivery strategies, and unresolved pharmacological parameters. In this review, we summarize the current advances in PRLM biosynthesis, signaling pathways, and biological functions across multiple disease contexts. We also discuss emerging therapeutic strategies, biomarker development, and knowledge gaps that require further investigation. PRLM research offers a promising framework for nextgeneration resolution-based therapeutic interventions.  \nKeywords Pro-resolving lipid mediators, Inflammation resolution, Biosynthesis and receptor signaling, Immune regulation and tissue repair, Translational medicine  \n†Chaofu Li, Zimu Wang andYukun Yang contributed equally to this work and share first authorship.  \n*Correspondence: Jun Xiao [xj73wy@163.com](xj73wy@163.com)[ ](xj73wy@163.com)Li Shen [shen.li1@zs-hospital.sh.cn](shen.li1@zs-hospital.sh.cn)[ ](shen.li1@zs-hospital.sh.cn)Wei Wu [david2015@cqu.edu.cn](david2015@cqu.edu.cn)[ ](david2015@cqu.edu.cn)Chuanwei Li[lichuanwei@cqu.edu.cn](lichuanwei@cqu.edu.cn)  \nFull list of author information is available at the end of the article  \n© The Author(s) 2026. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/licenses/by/4.0/](http://creativecommons.org/licenses/by/4.0/.)[.](http://creativecommons.org/licenses/by/4.0/.)  \nLi et al. Molecular Biomedicine (2026) 7:1  \nIntroduction  \nTherapeutic strategies for chronic","cbCail3GWIDu1ixA","https://ap.wps.com/l/cbCail3GWIDu1ixA","pdf",5753899,47,"English","# Abstract\n# Introduction\n## Resolution-based therapeutic strategies\n## Role of PRLMs in inflammation resolution\n## Mechanisms of PRLM signaling","[{\"question\":\"为什么炎症的消退被认为是“主动”过程？\",\"answer\":\"炎症消退被理解为由机体协调的程序性生物过程，而不是炎症信号的被动衰减。该程序失败时，炎症可能持续并发展为慢性病理状态。\"},{\"question\":\"PRLMs 与传统抗炎药物的关键区别是什么？\",\"answer\":\"传统抗炎药可抑制炎症介质，但不能恢复免疫平衡，也不主动促进消退；长期用药还可能影响宿主防御与组织修复。PRLMs 则通过参与专门的促消退程序来调节免疫稳态。\"},{\"question\":\"PRLMs 主要通过哪些机制发挥促消退作用？\",\"answer\":\"PRLMs 可通过受体依赖的信号通路作用，增强吞噬/清除（如促巨噬细胞吞噬与清除炎症细胞），调控细胞因子网络，并指导白细胞迁移，同时促进组织再生。\"}]","Pro-resolving lipid mediators in diseases - exploring the molecular basis and clinical implication | PDF",1790686559,118]