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A cross-sectional study in Ghana assessed knowledge, attitudes, and practices (KAP) about epilepsy among undergraduate students and traders using a structured questionnaire. Among 532 participants, 95.3% recognized epilepsy but 65.8% had poor knowledge, and 25.9% attributed epilepsy to ancestral sin. Attitudes were positive in 27.6%, while 84.2% reported societal discrimination; one-third showed good practices. Prior epilepsy knowledge significantly predicted more positive attitudes (AOR 95% CI 2.794–10.938, p\u003C0.001) and appropriate practices (AOR 95% CI 0.675–9.137, p=0.003), with test-based differences by sex and age. Targeted education is needed to correct misconceptions and improve 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was the study’s purpose regarding epilepsy knowledge, attitudes, and practices (KAP)?","Question",{"text":112,"@type":113},"To understand how knowledge, attitude, and practice (KAP) about epilepsy relate to misconceptions and to guide strategies that dispel myths.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What did the study find about participants’ knowledge of epilepsy?",{"text":117,"@type":113},"Most participants were aware of epilepsy (95.3%), but 65.8% had poor or inadequate knowledge, and misconceptions were common.",{"name":119,"@type":110,"acceptedAnswer":120},"How did prior knowledge influence attitudes and practices toward people living with epilepsy (PLWE)?",{"text":121,"@type":113},"Prior knowledge significantly predicted more positive attitudes (AOR 95% CI 2.794–10.938) and more appropriate practices (AOR 95% CI 0.675–9.137) toward 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Otua Otabil1  Abdala Mumuni Ussif2  Francis Tanam Djankpa3  Kwasi Agyen-Mensah4  Daniel Lawer Egbenya3  \n1 School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana  2 Department of Forensic Sciences, School of Biological Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana  3 Department of Physiology, School of Medical Sciences, College of Health and Allied Sciences, University of Cape Coast, Cape Coast, Ghana  4 Department of Surgery, School of Medical Sciences, College of  \nHealth and Allied Sciences, University of Cape Coast, Cape Coast, Ghana Correspondence: Daniel Lawer Egbenya ([daniel.egbenya@ucc.edu.gh](daniel.egbenya@ucc.edu.gh))  \nRevised: 9 December 2025  Accepted: 15 December 2025  \nKeywords: attitude | epilepsy | knowledge | misconception | practice | stigmatization  \nABSTRACT  \nBackground: Epilepsy-associated misconceptions may put persons living with epilepsy (PLWE) at risk of developing psychological disorders, resulting in a decrease in social contact.  \nPurpose: Understanding knowledge, attitude, and practice (KAP) about epilepsy is essential in developing strategies to dispel these epilepsy-associated myths and misconceptions.  \nMethod: This cross-sectional study assessed the KAP relating to epilepsy among undergraduate university students and traders in Ghana using a structured questionnaire.  \nFindings: Of the 532 participants surveyed, the majority were aware of epilepsy (95.3%), although 65.8% had poor/inadequate knowledge. Misconceptions were evident, as 25.9% of the participants reported that epilepsy is due to ancestral sin. Regarding attitudes toward epilepsy, 27.6% were positive, but 84.2% acknowledged societal discrimination against PLWE. A third of the participants exhibited good/appropriate practices toward PLWE. The Mann–Whitney U test showed a significant difference between males and females on the possession of adequate knowledge about epilepsy (male = 282.75 and female = 251.43, p = 0.018, n = 532) as well as practices toward PLWE (male = 287.34 and female = 247.17, p = 0.002, n = 532) . Also, knowledge about epilepsy (χ2 = 20.324, p = 0.018) and attitude toward PLWE (χ2 = 11.880, p = 0.036) vary by age group, as shown by the Kruskal– Wallis test. Prior knowledge about epilepsy significantly predicted positive attitudes [AOR: 95% CI (2.794, 10.938), p = 0.000] and practices [AOR: 95% CI (0.675, 9.137), p = 0.003] toward PLWE.  \nConclusion: Overall, there is the need for targeted educational interventions to correct misconceptions and improve KAP about epilepsy.  \n1  Introduction  \nEpilepsy is a neurological disease characterized by at least two unprovoked seizures that occur >24 h apart (Fisher et al. 2014) . Epilepsy stems from functional abnormality of brain cells. It  \ncan be triggered by known factors like traumatic brain injury, brain tumors, brain infections, other space-occupying brain pathologies, or specific congenital or genetic disorders and, in some cases, unknown causes. Despite being an age-old condition, epilepsy is associated with a number of misconceptions, which  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2025 The Author(s). Brain and Behavior published by Wiley Periodicals LLC.  \nBrain and Behavior, 2026; 16:e71161 1 of 17  \n[https://doi.org/10.1002/brb3.71161](https://doi.org/10.1002/brb3.71161)  \ntend to negatively affect the physical, mental, and psycho-social well-being of persons living with the condition.  \nEpilepsy, being one of the most frequently encountered brain diseases by health professionals, affects approximately 50 million people worldwide. It is one","cbCaiuA6ZuLzWqpu","https://ap.wps.com/l/cbCaiuA6ZuLzWqpu","pdf",826439,17,"English","# Introduction\n# Methods (Study Design and Participants)\n# Findings (Knowledge, Attitudes, Practices)\n# Discussion/Implications\n# Conclusion","[{\"question\":\"What was the study’s purpose regarding epilepsy knowledge, attitudes, and practices (KAP)?\",\"answer\":\"To understand how knowledge, attitude, and practice (KAP) about epilepsy relate to misconceptions and to guide strategies that dispel myths.\"},{\"question\":\"What did the study find about participants’ knowledge of epilepsy?\",\"answer\":\"Most participants were aware of epilepsy (95.3%), but 65.8% had poor or inadequate knowledge, and misconceptions were common.\"},{\"question\":\"How did prior knowledge influence attitudes and practices toward people living with epilepsy (PLWE)?\",\"answer\":\"Prior knowledge significantly predicted more positive attitudes (AOR 95% CI 2.794–10.938) and more appropriate practices (AOR 95% CI 0.675–9.137) toward PLWE.\"}]","Prior Knowledge of Epilepsy Predicts Positive Attitudes and Practices Toward Persons Living With Epilepsy - Research findings and KAP results | PDF",1790579160,43]