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The work surveys the biological basis of heritability and trait diversity, molecular mechanisms of genetic variants, gene expression regulation, and the role of nutrition in DNA replication, repair, and damage prevention. 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Alfredo Martinez  \nCiencias de la Alimentaci´on y Fisiologı´a  \nUniversidad de Navarra, Navarra, Spain  \nMartin Kohlmeier  \nHuman Research Core and Nutrigenetics Laboratory, UNC Nutrition Research Institute, and Schools of Medicine and Public Health Department of Nutrition Kannapolis, NC, United States  \nAcademic Press is an imprint of Elsevier  \n125 London Wall, London EC2Y 5AS, United Kingdom  \n525 B Street, Suite 1650, San Diego, CA 92101, United States  \n50 Hampshire Street, 5th Floor, Cambridge, MA 02139, United States The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom  \nCopyright © 2020 Elsevier Inc. All rights reserved.  \nNo part of this publication may be reproduced or transmitted in any form or by any means, electronic or mechanical, including photocopying, recording, or any information storage and retrieval system, without permission in writing from the publisher. Details on how to seek permission, further information about the Publisher’s permissions policies and our arrangements with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency, can be found [at our website:](at our website: www.elsevier.com/permissions)[ www.elsevier.com/permissions](at our website: www.elsevier.com/permissions).  \nThis book and the individual contributions contained in it are protected under copyright by the Publisher (other than as may be noted herein) .  \nNotices  \nKnowledge and best practice in this field are constantly changing. As new research and experience broaden our understanding, changes in research methods, professional practices, or medical treatment may become necessary.  \nPractitioners and researchers must always rely on their own experience and knowledge in evaluating and using any information, methods, compounds, or experiments described herein. In using such information or methods they should be mindful of their own safety and the safety of others, including parties for whom they have a professional responsibility.  \nTo the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors, assume any liability for any injury and/ or damage to persons or property as a matter of products liability, negligence or otherwise, or from any use or operation of any methods, products, instructions, or ideas contained in the material herein.  \nLibrary of Congress Cataloging-in-Publication Data  \nA catalog record for this book is available from the Library of Congress  \nBritish Library Cataloguing-in-Publication Data  \nA catalogue record for this book is available from the British Library ISBN: 978-0-12-804572-5  \nFor information on all Academic Press publications visit our website at [https://www.elsevier.com/books-and-journals](https://www.elsevier.com/books-and-journals)  \nPublisher: Charlotte Cockle  \nAcquisition Editor: Megan R. Ball  \nEditorial Project Manager: Devlin Person  \nProduction Project Manager: Paul Prasad Chandramohan  \nCover Designer: Miles Hitchen Typeset by TNQ Technologies  \nContents  \nContributors ix  \nEditor Biographies xv  \nPreface xvii  \nIntroduction xix  \nI  \nThe Biological Basis of Heritability  and Diversity   \n1. The Nature of Traits, Genes and  \nVariation 3  \nJOS´E L. VIZMANOS, NICHOLAS C.P. CROSS, AND  \nFRANCISCO J. NOVO  \n2. Molecular Biology of Genetic Variants 11 MARTIN KOHLMEIER  \n3. Regulation of Gene Expression 17 MARIA LUISA BONET AND ANDREU PALOU  \n4. The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair 27 MICHAEL FENECH  \n5. Genotyping and Sequencing 33 TERESA EZPONDA, GORKA ALKORTA-ARANBURU, FELIPE PR´OSPER, AND XABIER AGIRRE  \n6. RNA Analyses 41 FRANCISCO JAVIER RUIZ-OJEDA, JULIO PLA","cbCaiuQkt46TUS8W","https://ap.wps.com/l/cbCaiuQkt46TUS8W","pdf",16872779,588,"English","# Contents\n## Contributors\n## Editor Biographies\n## Preface\n## Introduction\n# I. The Biological Basis of Heritability and Diversity\n## 1. The Nature of Traits, Genes and Variation\n## 2. Molecular Biology of Genetic Variants\n## 3. Regulation of Gene Expression\n## 4. The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair\n## 5. Genotyping and Sequencing\n## 6. RNA Analyses\n## 7. Methods for Global Nutrigenomics and Precision Nutrition\n## 8. Epigenetic Analyses Tools for Nutrition Research\n## 9. Proteomic Analyses\n## 10. Metabolomics for Biomarker Discovery and to Derive Genetic Links to Disease\n## 11. Metagenomics\n## 12. A Broader View on Omics and Systems Biology\n## 13. Study Designs in Genomic Epidemiology\n## 14. Epistemology of Nutrigenetic Knowledge\n# II. Nutrigenetics\n## 15. Nutrigenetics and the Early Life Origins of Health and Disease: Effects of Protein Restriction\n## 16. Maternal Perinatal Nutrition and Offspring Programming\n## 17. Introduction to Epigenetics\n## 18. Genetics of Chrononutrition\n## 19. Screening for Inborn Errors of Metabolism\n## 20. Genomics of Eating Behavior and Appetite Regulation\n## 21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness\n## 22. Genetic Regulation of Energy Homeostasis: Obesity Implications\n## 23. Genetic Variations With Influence on the Individualized Response to Weight Loss Diets: FTO as Evidence","[{\"question\":\"What is the focus of this book on nutrigenetics and nutrigenomics?\",\"answer\":\"The book concentrates on fundamentals of individualized nutrition, explaining how genetic factors and nutritional components interact to influence health and disease-related outcomes.\"},{\"question\":\"Which biological mechanisms are discussed in the section on heritability and diversity?\",\"answer\":\"It covers the nature of traits, genes and variation, molecular biology of genetic variants, regulation of gene expression, and the role of nutrition in DNA replication, DNA damage prevention, and DNA repair.\"},{\"question\":\"What analytical approaches are included for nutrigenomics and nutrition research?\",\"answer\":\"The contents list methods such as genotyping and sequencing, RNA analyses, tools for epigenetic analyses, proteomic analyses, metabolomics for biomarker discovery, and metagenomics, along with systems biology and omics perspectives.\"}]","Principles of Nutrigenetics and Nutrigenomics - Fundamentals of Individualized Nutrition | PDF",1482]