[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-147581-en":3,"doc-seo-147581-105":29,"detail-sidebar-cat-0-en-105":90},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":20,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":20,"language":21,"language_code":22,"site_id":23,"html_lang":22,"table_of_contents":24,"faqs":25,"seo_title":26,"seo_description":14,"update_tm":27,"read_time":28},147581,962084925502,"Emma Mercer","https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8",7,"Healthcare","PRINCIPLE Platform Randomised Trial of Interventions against COVID-19 in older PEOPLE","The PRINCIPLE Trial is a UK national priority research study funded by the Department of Health and Social Care and run by the University of Oxford. It aims to find effective treatments for COVID-19 in older individuals. Participants are provided with study medication and instructions on dosage and administration. Some medications are already in common NHS use for other conditions and have been verified as safe for this study. Others are less familiar treatments that may offer benefits for COVID-19 but are not yet licensed in the UK. All treatments have received approval from the UK-Medicines and Health Care Products Regulatory Agency (MHRA) and the Urgent Public Health panel of independent experts. A clinician from the University of Oxford study team or the patient's GP has reviewed the patient's GP notes to confirm the medication's safety. For further information, individuals can visit www.principletrial.org or call 0800 138 0880. Professor Christopher Butler serves as the Chief Investigator and Director of the Primary Care Clinical Trials Unit.","Radcliffe Observatory Quarter, Woodstock Road, Oxford. OX2 6GG  \nTel: 0800 138 0880 [principle@phc.ox.ac.uk](principle@phc.ox.ac.uk) • [http://principletrial.org](http://principletrial.org)  \nDATE  \nTo whom it may concern  \nI can confirm that [insert patient name] has consented to take part in the PRINCIPLE trial, a research study to find effective treatments for COVID-19.  \nAs part of this study, [insert patient name] has been provided with the study medication and instructions on dosage and how to take the medication. Some study medications are already widely used in the NHS for other conditions and have been approved as safe for use in this study. Other medications are less familiar treatments which might have beneficial effects for the treatment of COVID-19, but which do not yet have a license for use in the UK. All of the treatments in the PRINCIPLE trial have been approved by the UK-Medicines and Health Care Products Regulatory Agency (MHRA), as well as the Urgent Public Health panel of independent experts. A clinician on the study team at the University of Oxford and/or the patients GP has reviewed [insert patient name]’s GP notes and confirmed that this medication is safe for them to take.  \nPRINCIPLE is a UK national priority study that is funded by the UK Department of Health and Social Care and run by the University of Oxford. For more information please visit [www.principletrial.org](www.principletrial.org) or call 0800 138 0880 .  \nYours Sincerely  \nProfessor Christopher Butler,  \nChief Investigator, PRINCIPLE Trial  \nDirector of the Primary Care Clinical Trials Unit  \nGeneral Practitioner","cbCaibiY7nFuTUc4","https://ap.wps.com/l/cbCaibiY7nFuTUc4","pdf",444518,1,"English","en",105,"# PRINCIPLE Trial Information\n## Study Medication and Safety Approvals\n## Funding and Administration\n## Contact Information","[{\"question\":\"What is the primary goal of the PRINCIPLE trial?\",\"answer\":\"The primary goal of the PRINCIPLE trial is to find effective treatments for COVID-19, particularly in older individuals.\"},{\"question\":\"Who is running and funding the PRINCIPLE trial?\",\"answer\":\"The PRINCIPLE trial is a UK national priority study funded by the UK Department of Health and Social Care and operated by the University of Oxford.\"},{\"question\":\"What is the role of the MHRA in the PRINCIPLE trial?\",\"answer\":\"The UK-Medicines and Health Care Products Regulatory Agency (MHRA), along with an Urgent Public Health panel of experts, has approved all the treatments used in the PRINCIPLE trial for safety and efficacy.\"}]","PRINCIPLE Platform Randomised Trial of Interventions against COVID-19 in older PEOPLE | 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