[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-326578-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-326578-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","primer-on-molecular-genetics-date-published-june-1992","Primer on Molecular Genetics - Date Published June 1992","","Primer on Molecular Genetics is an introduction to fundamental principles of molecular genetics for the Human Genome Project, drawn from the June 1992 DOE Human Genome 1991-92 Program Report. It is presented as an educational overview covering core concepts such as DNA, genes, chromosomes, and the logic behind mapping and sequencing. The primer further addresses mapping strategies (genetic linkage maps and physical maps), sequencing technologies and emerging approaches, and end goals for completing maps and sequences to find specific genes. It also discusses model organism research and informatics for collecting, storing, interpreting, and querying mapping and sequence databases, plus brief sections on nucleic acids and proteins, closing with a glossary and references.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & Report",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/primer-on-molecular-genetics-date-published-june-1992/326578/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/primer-on-molecular-genetics-date-published-june-1992/326578.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",5,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is the purpose of the Primer on Molecular Genetics?","Question",{"text":63,"@type":64},"It provides an introduction to basic principles of molecular genetics related to the Human Genome Project, explaining core concepts and workflows used in mapping and sequencing.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which topics are covered about genome structure and DNA?",{"text":68,"@type":64},"The primer explains the human genome as tightly coiled DNA with associated proteins organized into chromosomes, describes DNA base pairing and double-helix structure, and introduces DNA as the master blueprint for cellular instructions.",{"name":70,"@type":61,"acceptedAnswer":71},"How does the primer address mapping and sequencing?",{"text":72,"@type":64},"It outlines mapping and sequencing strategies, including genetic linkage maps and physical maps, discusses low- and high-resolution physical mapping, reviews current and developing sequencing technologies, and describes approaches for partial sequencing and end goals for identifying specific genes.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},326578,1790207515,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":107,"show_sort_weight":108,"slug":109},7,"Healthcare",40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":112,"slug":113},8,30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":111,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","DOE Human Genome Program  \nPrimer on Molecular Genetics  \nDate Published: June 1992  \nU.S. Department of Energy Office of Energy Research  \nOffice of Health and Environmental Research Washington, DC 20585  \nThe \"Primer on Molecular Genetics\" is taken from the June 1992 DOE Human Genome 1991-92 Program Report. The primer is intended to be an introduction to basic principles of molecular genetics pertaining to the genome project.  \nHuman Genome Management Information System Oak Ridge National Laboratory  \n1060 Commerce Park Oak Ridge, TN 37830  \nVoice: 865/576-6669  \nFax: 865/574-9888  \nE-mail: [bkq@ornl.gov](bkq@ornl.gov)  \nContents  \nPrimer on Molecular Genetics  \nRevised and expanded by Denise Casey (HGMIS) from the primer contributed by Charles Cantor and Sylvia Spengler (Lawrence Berkeley Laboratory) and published in the Human Genome 1989– 90 Program Report.  \nIntroduction ............................................................................................................. 5  \nDNA ............................................................................................................................... 6  \nGenes ............................................................................................................................ 7  \nChromosomes ............................................................................................................... 8  \nMapping and Sequencing the Human Genome ...................................... 10  \nMapping Strategies ..................................................................................................... 11  \nGenetic Linkage Maps ............................................................................................ 11  \nPhysical Maps ......................................................................................................... 13  \nLow-Resolution Physical Mapping ...................................................................... 14  \nChromosomal map ......................................................................................... 14  \ncDNA map ...................................................................................................... 14  \nHigh-Resolution Physical Mapping ..................................................................... 14  \nMacrorestriction maps: Top-down mapping ................................................... 16  \nContig maps: Bottom-up mapping .................................................................. 17  \nSequencing Technologies ........................................................................................... 18  \nCurrent Sequencing Technologies ......................................................................... 23  \nSequencing Technologies Under Development ..................................................... 24  \nPartial Sequencing to Facilitate Mapping, Gene Identification ............................... 24  \nEnd Games: Completing Maps and Sequences; Finding Specific Genes .................. 25  \nModel Organism Research .............................................................................. 27  \nInformatics: Data Collection and Interpretation ..................................... 27  \nCollecting and Storing Data ........................................................................................ 27  \nInterpreting Data ......................................................................................................... 28  \nMapping Databases .................................................................................................... 29  \nSequence Databases .................................................................................................. 29  \nNucleic Acids (DNA and RNA) ................................................................................ 29  \nProteins .................................................................................................................. 30  \nImpact of the Human Genome Project ....","cbCaivGTmQ1Qr6he","https://ap.wps.com/l/cbCaivGTmQ1Qr6he","pdf",692224,44,"English","# Primer on Molecular Genetics\n## Introduction\n## DNA\n## Genes\n## Chromosomes\n## Mapping and Sequencing the Human Genome\n## Mapping Strategies\n## Genetic Linkage Maps\n## Physical Maps\n## Low-Resolution Physical Mapping\n## Chromosomal map\n## cDNA map\n## High-Resolution Physical Mapping\n## Sequencing Technologies\n## Current Sequencing Technologies\n## Sequencing Technologies Under Development\n## Partial Sequencing to Facilitate Mapping, Gene Identification\n## End Games: Completing Maps and Sequences; Finding Specific Genes\n## Model Organism Research\n## Informatics: Data Collection and Interpretation\n## Collecting and Storing Data\n## Interpreting Data\n## Mapping Databases\n## Sequence Databases\n## Nucleic Acids (DNA and RNA)\n## Proteins\n## Impact of the Human Genome Project\n## Glossary","[{\"question\":\"What is the purpose of the Primer on Molecular Genetics?\",\"answer\":\"It provides an introduction to basic principles of molecular genetics related to the Human Genome Project, explaining core concepts and workflows used in mapping and sequencing.\"},{\"question\":\"Which topics are covered about genome structure and DNA?\",\"answer\":\"The primer explains the human genome as tightly coiled DNA with associated proteins organized into chromosomes, describes DNA base pairing and double-helix structure, and introduces DNA as the master blueprint for cellular instructions.\"},{\"question\":\"How does the primer address mapping and sequencing?\",\"answer\":\"It outlines mapping and sequencing strategies, including genetic linkage maps and physical maps, discusses low- and high-resolution physical mapping, reviews current and developing sequencing technologies, and describes approaches for partial sequencing and end goals for identifying specific genes.\"}]","Primer on Molecular Genetics - Date Published June 1992 | PDF",1789974651,111]