[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-465764-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-465764-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","primary-hepatic-squamous-cell-carcinoma-case-report","Primary Hepatic Squamous Cell Carcinoma - Case Report","","Rare primary hepatic squamous cell carcinoma (SCC) is presented through an 85-year-old male case with multiple liver nodules and atypical imaging. Tests were negative for hepatitis B surface antigen and hepatitis C antibodies, and serum tumor markers were within normal limits. Contrast-enhanced ultrasonography showed hypervascularity, early washout, and postvascular defects. Histology and immunohistochemistry confirmed SCC, suggesting possible involvement of hepatic progenitor cells and de novo carcinogenesis.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/primary-hepatic-squamous-cell-carcinoma-case-report/465764/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/primary-hepatic-squamous-cell-carcinoma-case-report/465764.png","ImageObject",300,407,{"name":42,"@type":43},"Jordan Avery","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What clinical and imaging findings characterized the primary hepatic SCC case?","Question",{"text":63,"@type":64},"The patient had multiple liver nodules with atypical imaging, and contrast-enhanced ultrasonography showed hypervascular nodules in the early vascular phase, early washout in the portal phase, and a postvascular defect.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What laboratory and viral test results were reported?",{"text":68,"@type":64},"The case was negative for hepatitis B surface antigen and hepatitis C virus antibody, and serum tumor markers were all within normal limits.",{"name":70,"@type":61,"acceptedAnswer":71},"How was the diagnosis supported histologically and by immunohistochemistry?",{"text":72,"@type":64},"Histopathology showed irregular tumor cells with large hyperchromatic nuclei and basophilic cytoplasm with dense fibrous stroma. Immunohistochemistry was positive for AE1/AE3, p40, CK5/6, c-kit, and NCAM.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},465764,1791170312,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},1099523882367,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Case Report  \nPrimary Hepatic Squamous Cell Carcinoma  \nSoo Ryang Kim 1, Soo Ki Kim 1, *, Hisato Kobayashi 2, Toyokazu Okuda 3, Yumi Fujii 1, Makiho Sakamoto 1, Yu-ichiro Koma 4, Osamu Nakashima 5, Motoko Sasaki 6, Akira Asai 7 and Hiroki Nishikawa 7  \nAcademic Editor: Hiroko Naganuma  \nReceived: 12 November 2025  \nRevised: 24 December 2025  \nAccepted: 25 December 2025  \nPublished: 1 January 2026  \nCopyright: © 2026 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license.  \n1 Department of Gastroenterology, Kobe Asahi Hospital, Kobe 653-0801, Japan;  \n[asahi-hp@arion.ocn.ne.jp](asahi-hp@arion.ocn.ne.jp) (S.R.K.)  \n2 Department of Radiology, Kobe Asahi Hospital, Kobe 653-0801, Japan  \n3 Department of Surgery, Kobe Asahi Hospital, Kobe 653-0801, Japan  \n4 Division of Pathology, Department of Pathology, Kobe University Graduate School of Medicine, Kobe 650-0017, Japan  \n5 St. Mary’s Hospital, Laboratory Services Center, Kurume 830-8543, Japan  \n6 Department of Human Pathology, Kanazawa University Graduate School of Medicine, Kanazawa 920-8640, Japan  \n7 The Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan  \n* Correspondence: [kinggold@kobe-asahi-hp.com](kinggold@kobe-asahi-hp.com)  \nAbstract  \nBackground and Clinical Significance: We present an 85-year-old male case of primary hepatic SCC manifesting as multiple liver nodules with atypical imaging findings. Case Presentation: The patient was negative for hepatitis B surface antigen and hepatitis C virus antibody. Serum tumor markers were all within normal limits. Contrast-enhanced ultrasonography with perflubutane demonstrated hypervascular nodules in the early vascular phase, early washout in the portal phase, and a defect in the postvascular phase (10 mm in S5 and 25 mm in S6) . Histopathological examination revealed irregularly shaped tumor cells with large hyperchromatic nuclei and basophilic cytoplasm, surrounded by dense fibrous stroma forming cords, solid nests, and sheet-like structures. Immunohistochemical analysis showed positivity for AE1/AE3, p40, CK5/6, c-kit, and NCAM. Conclusions: The lesions were diagnosed as primary hepatic squamous cell carcinoma and suggested the possible involvement of hepatic progenitor cells, supporting the hypothesis of de novo carcinogenesis.  \nKeywords: imaging studies; de novo carcinogenesis; immunohistochemistry; primary squamous cell carcinoma of the liver; hepatic progenitor cell  \n1. Introduction  \nPrimary squamous cell carcinoma (SCC) of the liver is an exceptionally uncommon histopathological diagnosis. Only 32 cases have been reported in the English-language literature from the 1970s to date [1,2] . This low number of reported cases highlights the rarity of this malignancy and the consequently limited understanding of the disease [1] .  \nSCC typically arises in tissues lined by squamous epithelium, including the skin, cervix, lungs, esophagus, and rectum. The liver parenchyma normally lacks squamous epithelial cells, making primary SCC in this organ exceptionally rare [1,3] . Primary hepatic SCC is often misdiagnosed [1,2,4] . Furthermore, its true histological origin remains a subject of controversy. Current reports suggest that this tumor may not arise directly from  \nliver tissue; instead, it is thought to originate from the epithelial lining of developmental hepatic cysts, areas of chronic inflammation, or through the malignant transformation of the biliary epithelium [1,5] . Potential associations have been noted between hepatic SCC and conditions such as male gender, hepatic cysts, hepatolithiasis, solitary benign non-parasitic hepatic cysts (SBNHC), hepatic teratomas, and liver cirrhosis. However, cases have also been documented in patients without any preceding liver conditions or identified risk factors [5] .  \nWhile a few cases of pr","cbCainSoYwbN0mPI","https://ap.wps.com/l/cbCainSoYwbN0mPI","pdf",18383218,14,"English","# Abstract\n# Introduction\n# Case Report\n## Chief Complaints\n## History of Present and Past Illness\n## Personal and Family History\n## Physical Examination\n## Laboratory Examinations","[{\"question\":\"What clinical and imaging findings characterized the primary hepatic SCC case?\",\"answer\":\"The patient had multiple liver nodules with atypical imaging, and contrast-enhanced ultrasonography showed hypervascular nodules in the early vascular phase, early washout in the portal phase, and a postvascular defect.\"},{\"question\":\"What laboratory and viral test results were reported?\",\"answer\":\"The case was negative for hepatitis B surface antigen and hepatitis C virus antibody, and serum tumor markers were all within normal limits.\"},{\"question\":\"How was the diagnosis supported histologically and by immunohistochemistry?\",\"answer\":\"Histopathology showed irregular tumor cells with large hyperchromatic nuclei and basophilic cytoplasm with dense fibrous stroma. Immunohistochemistry was positive for AE1/AE3, p40, CK5/6, c-kit, and NCAM.\"}]","Primary Hepatic Squamous Cell Carcinoma - Case Report | PDF",1790770024,35]