[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-459954-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-459954-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","primary-ewing-sarcoma-of-the-uterine-cervix-a-case-report-and-comprehensive-review","Primary Ewing sarcoma of the uterine cervix - a case report and comprehensive review","","Primary Ewing sarcoma of the uterine cervix is exceptionally rare and highly aggressive, with only 34 English-language cases previously reported. The article details a 32-year-old multiparous woman presenting with foul-smelling vaginal discharge and irregular bleeding, whose exam showed a 6×6 cm friable cervical mass extending into the upper vagina. Imaging revealed an FDG-avid cervical lesion with regional lymphadenopathy, and histopathology confirmed Ewing sarcoma via immunohistochemistry and EWSR1 rearrangement. Treatment used neoadjuvant VDC/PIE chemotherapy, surgery, adjuvant chemotherapy, and pelvic radiotherapy; recurrence with distant metastases occurred after a 7-month disease-free interval.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/primary-ewing-sarcoma-of-the-uterine-cervix-a-case-report-and-comprehensive-review/459954/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/primary-ewing-sarcoma-of-the-uterine-cervix-a-case-report-and-comprehensive-review/459954.png","ImageObject",300,407,{"name":42,"@type":43},"Grenda","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-03","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What symptoms led to the presentation of this cervical Ewing sarcoma case?","Question",{"text":63,"@type":64},"The patient reported foul-smelling vaginal discharge and irregular uterine bleeding. Examination found a friable cervical mass extending into the upper vagina.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was the diagnosis of Ewing sarcoma confirmed?",{"text":68,"@type":64},"Histopathology supported by immunohistochemistry and fluorescence in situ hybridization confirmed Ewing sarcoma with an EWSR1 gene rearrangement.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment did the patient receive and what was the outcome?",{"text":72,"@type":64},"She received neoadjuvant VDC followed by PIE chemotherapy, then surgical resection, adjuvant chemotherapy, and pelvic radiotherapy. Despite initial disease control, the disease recurred with distant metastases after 7 months and the patient died 9 months after diagnosis.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},459954,1791068344,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":55,"preview_page_count":4},7971474921005,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Korean Journal of Clinical Oncology 2025;21:164-168 [https://doi.org/10.14216/kjco.25373](https://doi.org/10.14216/kjco.25373)  \n[pISSN 1738-8082](pISSN 1738-8082) ∙ eISSN 2288-4084  \nCase Report  \nPrimary Ewing sarcoma of the uterine cervix: a case report and comprehensive review  \nSuday Halder1, Seema Singhal1, Sandeep Mathur2, Sameer Bakhshi3, Rambha Pandey4, Vidushi Kulshrestha1, Ekta Dhamija5, Neena Malhotra1  \n¹Department of Obstetrics and Gynecology, All India Institute of Medical Sciences (AIIMS), New Delhi, India 2Department of Pathology, All India Institute of Medical Sciences (AIIMS), New Delhi, India  \n3Department of Medical Oncology BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India 4Department of Radiation Oncology, All India Institute of Medical Sciences (AIIMS), New Delhi, India 5Department of Radiology BRAIRCH, All India Institute of Medical Sciences (AIIMS), New Delhi, India  \nPrimary Ewing sarcoma of the uterine cervix is an exceptionally rare and aggressive malignancy, with only 34 cases reported in the literature. Early recognition and prompt multimodal treatment are essential due to its poor prognosis. We report a case involving a 32-year-old multiparous woman who presented with foul-smelling vaginal discharge and irregular bleeding. Clinical examination revealed a 6× 6 cm friable cervical mass extending into the upper vagina. Imaging demonstrated an FDG-avid cervical mass with regional lymphadenopathy. Histopathological analysis, supported by immunohistochemistry and fluorescence in situ hybridization, confirmed Ewing sarcoma with EWSR1 gene rearrangement. The patient received neoadjuvant chemotherapy with VDC (vincristine, doxorubicin, cyclophosphamide) and PIE (cisplatin, ifosfamide, etoposide) regimens, followed by surgical resection, adjuvant chemotherapy, and pelvic radiotherapy. Although initial disease control was achieved, the patient experienced disease recurrence with distant metastases after a 7-month disease-free interval and succumbed to the illness 9 months after diagnosis. This case underscores the importance of including Ewing sarcoma in the differential diagnosis of rapidly growing cervical tumors, particularly in young women. A multidisciplinary approach involving early molecular diagnostics and aggressive combined therapy is critical to improving clinical outcomes in such rare and aggressive cases.  \nKeywords: Ewing sarcoma, Uterine cervix, Rare tumor, EWSR1 rearrangement, Case reports  \nINTRODUCTION  \nEwing sarcoma (ES), also known as primitive neuroectodermal tumor (PNET), is a rare, aggressive malignancy originating from primitive neuroectodermal cells. Characterized histologically by sheets of small, round, blue cells, ES/PNET typically arises in bones or soft tissues of children and adolescents, with uterine cervical involvement being exceedingly rare—only 34 cases have been reported in English-language literature to date (Table 1) [1]. ES and PNET are now considered part ofa tumor spectrum due to over-  \nReceived: Sep 6, 2025 Revised: Oct 17, 2025 Accepted: Nov 20, 2025  \nCorrespondence to: Seema Singhal  \nDepartment of Obstetrics and Gynecology, Mother and Child Block, All India Institutes of Medical Sciences (AIIMS), New Delhi Ansari Nagar East, New Delhi 110029, India  \nTel: +91-11-29576779, Fax: +91-11-26593012  \n[E-mail:](E-mail: drseemasinghal@gmail.com)[ drseemasinghal@gmail.com](E-mail: drseemasinghal@gmail.com)[ ](E-mail: drseemasinghal@gmail.com)© 2025 Korean Society of Surgical Oncology  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([http://creativecommons.org/licenses/by-nc/4.0](http://creativecommons.org/licenses/by-nc/4.0)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nlapping histological and genetic features, notably the t(11;22)(q24;q12) translocation resulting in theEWSR1–","cbCaivTsaYAtiNqH","https://ap.wps.com/l/cbCaivTsaYAtiNqH","pdf",783820,"English","# Introduction\n# Case report\n## Patient presentation and diagnostic workup\n# Treatment and outcomes\n# Discussion","[{\"question\":\"What symptoms led to the presentation of this cervical Ewing sarcoma case?\",\"answer\":\"The patient reported foul-smelling vaginal discharge and irregular uterine bleeding. Examination found a friable cervical mass extending into the upper vagina.\"},{\"question\":\"How was the diagnosis of Ewing sarcoma confirmed?\",\"answer\":\"Histopathology supported by immunohistochemistry and fluorescence in situ hybridization confirmed Ewing sarcoma with an EWSR1 gene rearrangement.\"},{\"question\":\"What treatment did the patient receive and what was the outcome?\",\"answer\":\"She received neoadjuvant VDC followed by PIE chemotherapy, then surgical resection, adjuvant chemotherapy, and pelvic radiotherapy. Despite initial disease control, the disease recurred with distant metastases after 7 months and the patient died 9 months after diagnosis.\"}]","Primary Ewing sarcoma of the uterine cervix - a case report and comprehensive review | PDF",1790757344]