[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-452767-105":59,"doc-detail-452767-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","primary-cutaneous-peripheral-t-cell-lymphoma-with-follicular-helper-t-cell-phenotype","Primary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype","","An otherwise healthy 82-year-old woman developed recurrent, asymptomatic erythematous papulo-nodular lesions on the face and extremities. Skin biopsy showed a dense, non-epidermotropic lymphohistiocytic infiltrate with granulomatous features and mixed atypical lymphoid cells and plasma cells. Immunohistochemistry demonstrated predominant CD4+ T-cells with TFH phenotype (PD1+, CXCL13+, BCL6+) plus EBV-negative monotypic B-cells. BIOMED2 PCR confirmed T and B clonality, with RHOA p.G17V and additional TET2/DNMT3A mutations by NGS. Staging was negative for extracutaneous disease, while peripheral blood showed a minimal atypical CD4+ TFH-marked population. A concurrent cutaneous squamous cell carcinoma harbored a peritumoral TFH lymphoid infiltrate sharing the same clonal profile.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/primary-cutaneous-peripheral-t-cell-lymphoma-with-follicular-helper-t-cell-phenotype/452767/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/primary-cutaneous-peripheral-t-cell-lymphoma-with-follicular-helper-t-cell-phenotype/452767.png","ImageObject",300,407,{"name":92,"@type":93},"acoobca","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What clinical presentation was described in the reported patient?","Question",{"text":113,"@type":114},"The patient, an otherwise healthy 82-year-old woman, presented with recurrent, asymptomatic erythematous papulo-nodular lesions on the face and extremities.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What key pathology and immunophenotype supported the diagnosis?",{"text":118,"@type":114},"Biopsy showed a dense, non-epidermotropic infiltrate with granulomatous features and atypical medium-to-large lymphoid cells. Immunohistochemistry demonstrated predominant CD4+ T-cells with TFH phenotype (PD1+, CXCL13+, BCL6+) and admixed EBV-negative monotypic B-cells.",{"name":120,"@type":111,"acceptedAnswer":121},"Which molecular findings and staging results were reported?",{"text":122,"@type":114},"Clonality for both T and B cells was confirmed by BIOMED2 PCR, with an identified RHOA p.G17V mutation and additional TET2 and DNMT3A mutations by next-generation sequencing. Complete staging showed no nodal or visceral involvement, though a minimal TFH-marked atypical CD4+ population was detected in peripheral blood.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},452767,1790832437,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},3985747870733,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","Journal of Cutaneous Pathology  \nCASE STUDY  OPEN ACCESS   \nPrimary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype  \nNidia Planella-Fontanillas1,2  | Andrea Molina-Alvarez2,3  | Lluís Colomo-Saperas2,3  | Roger Rovira1 | Monica Gonzàlez-Farré3 | Carlos Barranco-Sanz3 | Xavier Calvo4  | Clara Nadal-Pellisé5 | Fernando Gallardo1,2 | Ramon M. Pujol1,2   \n1Department of Dermatology, Hospital del Mar Research Institute (IMIM), Barcelona, Spain | 2Department of Medicine and Life Sciences  \n(MELIS), Universitat Pompeu Fabra (UPF), Barcelona, Spain | 3Department of Pathology, Hospital del Mar Research Institute (IMIM), Barcelona, Spain | 4Laboratori de Citologia Hematològica, Servei de Patologia, Grup de Recerca Translacional en Neoplàsies Hematològiques (GRETNHE), Hospital  \ndel Mar Research Institute (IMIM), Barcelona, Spain | 5Department of Hematology, Hospital del Mar Research Institute (IMIM), Barcelona, Spain Correspondence: Ramon M. Pujol ([rpujol@hmar.cat](rpujol@hmar.cat))  \nReceived: 25 February 2025 | Revised: 7 September 2025 | Accepted: 15 October 2025  \nFunding: The authors received no specific funding for this work.  \nABSTRACT  \nAn otherwise healthy 82-year-old woman presented with recurrent, asymptomatic erythematous papulo-nodular lesions on the face and extremities. A skin biopsy revealed a dense, non-epidermotropic lymphohistiocytic infiltrate with granulomatous features and a mixed population of medium-sized atypical lymphoid cells and plasma cells. Immunohistochemistry demonstrated a predominant CD4+ T-cell population with a T-follicular helper (TFH) phenotype (PD1+, CXCL13+, BCL6+), admixed with EBV-negative monotypic B-cells. Clonality was confirmed for both T and B cells by BIOMED2 PCR, and a RHOA p.G17V mutation was identified. Next-generation sequencing revealed additional mutations in TET2 and DNMT3A. Complete staging studies showed no nodal or visceral involvement. A minimal circulating population (0.11%) of atypical CD4+ T-cells with surface CD3 loss and TFH markers was detected in peripheral blood. Based on clinical and histopathological findings, a diagnosis of primary cutaneous peripheral T-cell lymphoma with TFH phenotype (pcPTCL-TFH) was made. The patient also developed a cutaneoussquamous cell carcinoma, in which a peritumoral TFH lymphoid infiltrate with the same clonal features was identified. This case illustrates the diagnostic complexity of pcPTCL-TFH and its potential overlap with systemic TFH-derived lymphomas, underscoring the need for molecular work-up and close clinical follow-up to detect possible extracutaneous progression.  \n1 | Introduction  \nPrimary cutaneous presentation of peripheral T-cell lymphoma with a T-follicular helper cell phenotype (pcPTCL-TFH) was first described by Battistella et al. [1], in 2012, in a series of five patients presenting with multiple plaques or nodules showing histopathologically a diffuse, non-epidermotropic dermal lymphoid infiltrate composed of T and B cells, with atypical medium-tolarge lymphoid cells variably expressing TFH markers.  \nSince this initial description, additional cases and series have expanded our understanding of this rare lymphoma subtype [2–8]. Some patients present an indolent disease, whereas others experience a progressive course with recurrences, often requiring multiple treatments and occasionally developing extracutaneous involvement [7]. Morphological and immunophenotypical features are consistent across cases, with some of them showing additional B-cell clonal populations to the primary TFHT-cell component. Targeted mutational analyses have revealed  \nThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.  \n© 2025 The Author(s). Journal of Cutaneous Pathology published by J","cbCaig1rRvHdwe4d","https://ap.wps.com/l/cbCaig1rRvHdwe4d","pdf",2184243,"English","# Introduction\n## Case Report","[{\"question\":\"What clinical presentation was described in the reported patient?\",\"answer\":\"The patient, an otherwise healthy 82-year-old woman, presented with recurrent, asymptomatic erythematous papulo-nodular lesions on the face and extremities.\"},{\"question\":\"What key pathology and immunophenotype supported the diagnosis?\",\"answer\":\"Biopsy showed a dense, non-epidermotropic infiltrate with granulomatous features and atypical medium-to-large lymphoid cells. Immunohistochemistry demonstrated predominant CD4+ T-cells with TFH phenotype (PD1+, CXCL13+, BCL6+) and admixed EBV-negative monotypic B-cells.\"},{\"question\":\"Which molecular findings and staging results were reported?\",\"answer\":\"Clonality for both T and B cells was confirmed by BIOMED2 PCR, with an identified RHOA p.G17V mutation and additional TET2 and DNMT3A mutations by next-generation sequencing. Complete staging showed no nodal or visceral involvement, though a minimal TFH-marked atypical CD4+ population was detected in peripheral blood.\"}]","Primary Cutaneous Peripheral T-Cell Lymphoma With Follicular Helper T-Cell Phenotype | PDF",1790737667,15]