[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-350014-105":59,"doc-detail-350014-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","prevention-strategies-for-hereditary-gynaecological-cancer-in-lynch-syndrome-review","Prevention strategies for hereditary gynaecological cancer in Lynch syndrome - Review","","Lynch syndrome is a hereditary predisposition linked to increased lifetime risk of colorectal, endometrial, ovarian, and other malignancies. This review summarizes evidence-based prevention strategies for gynaecological cancers, focusing on risk-reducing hysterectomy with bilateral salpingo-oophorectomy as the most effective option, while weighing surgical morbidity and premature menopause. It also evaluates surveillance with transvaginal ultrasound and endometrial biopsy, notes heterogeneous evidence without mortality benefit, and reviews emerging non-invasive approaches requiring prospective validation. It further discusses chemoprevention with hormonal agents and aspirin, vaccination research, and the uncertain role of lifestyle measures.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prevention-strategies-for-hereditary-gynaecological-cancer-in-lynch-syndrome-review/350014/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prevention-strategies-for-hereditary-gynaecological-cancer-in-lynch-syndrome-review/350014.png","ImageObject",300,407,{"name":92,"@type":93},"\tJames","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-26","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What prevention strategy is most effective for reducing gynaecological cancer incidence and mortality in Lynch syndrome?","Question",{"text":112,"@type":113},"Risk-reducing hysterectomy with bilateral salpingo-oophorectomy is described as the most effective intervention for lowering cancer incidence and mortality.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Why may gynaecological surveillance not reduce mortality in Lynch syndrome?",{"text":117,"@type":113},"The review states that available evidence for surveillance using transvaginal ultrasound and endometrial biopsy is heterogeneous and indicates no benefit in reducing mortality.",{"name":119,"@type":110,"acceptedAnswer":120},"What new non-invasive prevention approaches are being explored?",{"text":121,"@type":113},"Emerging approaches include biomarker-based detection using DNA methylation analysis of cervicovaginal samples, liquid biopsy techniques, and microbiome profiling, which require prospective validation in Lynch-specific populations.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},350014,1790464608,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Familial Cancer (2026) 25:33  \n[https://doi.org/10.1007/s10689-026-00548-1](https://doi.org/10.1007/s10689-026-00548-1)  \nREVIEW  \nPrevention strategies for hereditary gynaecological cancer in Lynch syndrome  \nKevin J. J. Kwinten1 · Jean-Ellen Johnson2 · Anne M. van Altena1 · Nicoline Hoogerbrugge3 · Emma J. Davidson2,4,5,6 · Joanne A. de Hullu1  \nReceived: 10 December 2025 / Accepted: 16 March 2026 © The Author(s) 2026  \nAbstract  \nLynch syndrome is a hereditary cancer predisposition condition associated with an elevated lifetime risk of colorectal, endometrial, ovarian, and several other malignancies. This review provides an updated overview of evidence-based prevention strategies for gynaecological cancers in patients with Lynch syndrome. Risk-reducing hysterectomy with bilateral salpingo-oophorectomy is the most effective intervention for lowering cancer incidence and mortality, but is associated with surgical morbidity and requires careful consideration of reproductive plans and the adverse consequences of premature menopause. Gynaecological surveillance using transvaginal ultrasound and endometrial biopsy is widely implemented as an alternative; however, available evidence is heterogeneous and indicates no benefit in reducing mortality. Novel approaches—such as biomarker-based detection using DNA methylation analysis of cervicovaginal samples, liquid biopsy techniques, and microbiome profiling—offer promising, non-invasive alternatives but require prospective validation in Lynch-specific populations. Chemoprevention with hormonal agents and aspirin may reduce cancer risk, while vaccine-based prevention strategies are under active investigation. Adoption of a healthy lifestyle is recommended for overall health, although its impact on gynaecological cancer risk in Lynch syndrome remains uncertain. Future research should prioritise prospective trials to establish optimal cancer prevention protocols, validate novel biomarkers and preventive cancer vaccine strategies, and evaluate the long-term effectiveness, acceptability, and cost-effectiveness of combined preventive approaches to improve outcomes in this high hereditary-risk population.  \nKeywords Lynch syndrome · Endometrial cancer · Ovarian cancer · Prevention of cancer · Early detection of cancer  \nKevin J. J. Kwinten and Jean-Ellen Johnson contributed equally to this work.  \n􀀍 Kevin J. J. Kwinten [kevin.kwinten@radboudumc.nl](kevin.kwinten@radboudumc.nl)  \n1 Department of Obstetrics and Gynecology, Radboud University Medical Center, Nijmegen, The Netherlands  \n2 Department of Obstetrics and Gynaecology, St Mary’s Hospital, Manchester University NHS Foundation Trust, Manchester Academic Health Science Centre, Manchester, UK  \n3 Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands  \n4 Gynaecological Oncology Research Group, Division of Cancer Sciences, University of Manchester, Faculty of Biology, Medicine and Health, Manchester, UK  \n5 Centre for Reproductive Health, Institute for Regeneration and Repair, University of Edinburgh, Edinburgh, UK  \n6 CRUK Scotland Centre, Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK  \nIntroduction  \nLynch syndrome is an autosomal dominantly inherited cancer predisposition syndrome caused by germline pathogenic variants (gPV) affecting one of the DNA mismatch repair genes—MLH1, MSH2 (or EPCAM deletions), MSH6, or PMS2 [1] . Women with Lynch syndrome have substantially increased lifetime risks of colorectal, endometrial, and ovarian cancer, along with moderately elevated risks of several less common malignancies, including gastric, duodenal, pancreatic, and urinary tract cancers [2] .  \nThe incidence of gynaecological cancer varies considerably by mismatch repair gene. By age 75, the cumulative incidences of endometrial and ovarian cancer are estimated at 37% and 8% for individuals with an MLH1 gPV, 44% and 13% for an MSH2 gPV, 46% and 6% for an MSH6 gPV, and 21% and 3% for a ","cbCaidZGlWAZwdCQ","https://ap.wps.com/l/cbCaidZGlWAZwdCQ","pdf",1097331,15,"English","# Introduction\n# Gynaecological surveillance","[{\"question\":\"What prevention strategy is most effective for reducing gynaecological cancer incidence and mortality in Lynch syndrome?\",\"answer\":\"Risk-reducing hysterectomy with bilateral salpingo-oophorectomy is described as the most effective intervention for lowering cancer incidence and mortality.\"},{\"question\":\"Why may gynaecological surveillance not reduce mortality in Lynch syndrome?\",\"answer\":\"The review states that available evidence for surveillance using transvaginal ultrasound and endometrial biopsy is heterogeneous and indicates no benefit in reducing mortality.\"},{\"question\":\"What new non-invasive prevention approaches are being explored?\",\"answer\":\"Emerging approaches include biomarker-based detection using DNA methylation analysis of cervicovaginal samples, liquid biopsy techniques, and microbiome profiling, which require prospective validation in Lynch-specific populations.\"}]","Prevention strategies for hereditary gynaecological cancer in Lynch syndrome - Review | PDF",1790086728,38]