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Evidence suggests CeD patients face an elevated risk of specific malignant neoplasms, including gastrointestinal cancers, lymphomas, skin malignancies, and other malignancies. This observational study evaluates the prevalence of malignant neoplasms in hospitalized CeD patients in the United States using the National Inpatient Sample from January 2000 to December 2019, with propensity score matching to compare CeD versus non-CeD patients.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/prevalence-of-malignant-neoplasms-in-celiac-disease-patients-a-nationwide-united-states-population-based-study-observational-study/333672/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/prevalence-of-malignant-neoplasms-in-celiac-disease-patients-a-nationwide-united-states-population-based-study-observational-study/333672.png","ImageObject",300,407,{"name":92,"@type":93},"Oliver","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study aim regarding celiac disease and malignant neoplasms?","Question",{"text":112,"@type":113},"To investigate the prevalence of malignant neoplasms in hospitalized celiac disease patients in the United States.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What data and study period were used to identify the celiac disease cohort?",{"text":117,"@type":113},"Data from the National Inpatient Sample spanning two decades, from January 2000 to December 2019, were used to identify 529,842 celiac disease patients.",{"name":119,"@type":110,"acceptedAnswer":120},"How were celiac disease patients compared with the general non-CeD population?",{"text":121,"@type":113},"Propensity score matching was applied using age, sex, race, and calendar year at a 1:1 ratio between celiac disease patients and non-CeD patients.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},333672,1790970035,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","| W | J | C | O | World Journal of\u003Cbr>Clinical Oncology |\n| --- | --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Clin Oncol 2024 August 24; 15(8): 1048-1060  \nDOI: 10.5306/wjco.v15.i8.1048 ISSN 2218-4333 (online)  \nORIGINAL ARTICLE  \nObservational Study  \nPrevalence of malignant neoplasms in celiac disease patients-a nationwide United States population-based study  \nMaryam Bilal Haider, Ali Al Sbihi, Sushmitha Nanja Reddy, Peter Green  \nSpecialty type: Oncology  \nProvenance and peer review:  \nUnsolicited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade B, Grade B  \nNovelty: Grade B, Grade B  \nCreativity or Innovation: Grade B, Grade B  \nScientific Significance: Grade B, Grade B  \nP-Reviewer: Roganovic J; Velikova TV  \nReceived: March 22, 2024  \nRevised: June 10, 2024  \nAccepted: June 27, 2024  \nPublished online: August 24, 2024  \nProcessing time: 146 Days and 18 Hours  \nMaryam Bilal Haider, Department of Gastroenterology, Northshore University Health System, Evanston, IL 60201, United States  \nAli Al Sbihi, Department of Hematology/Oncology, University of Miami Miller School of Medicine, Miami, FL 33101, United States  \nSushmitha Nanja Reddy, Department of Hematology/Oncology, Karmanos Cancer Institute/Wayne State University, Detroit, MI 48235, United States  \nPeter Green, Celiac Disease Center, Columbia University, New York, NY 10032, United States  \nCorresponding author: Maryam Bilal Haider, MD, Doctor, Department of Gastroenterology, Northshore University Health System, 2650 Ridge Ave, Evanston, IL 60201, United States.  \n[mhaider@northshore.org](mhaider@northshore.org)  \nAbstract  \nBACKGROUND  \nCeliac disease (CeD) is an autoimmune disorder triggered by the immune response to gluten in genetically predisposed individuals. Recent research has unveiled a heightened risk of developing specific malignant neoplasms (MN) and various malignancies, including gastrointestinal, lymphomas, skin, and others, in individuals with CeD.  \nAIM  \nTo investigate the prevalence of MN in hospitalized CeD patients in the United States.  \nMETHODS  \nUsing data from the National Inpatient Sample spanning two decades, from January 2000 to December 2019, we identified 529842 CeD patients, of which 78128 (14.75%) had MN. Propensity score matching, based on age, sex, race, and calendar year, was employed to compare CeD patients with the general non-CeD population at a 1:1 ratio.  \nRESULTS  \nPositive associations were observed for several malignancies, including small intestine, lymphoma, nonmelanoma skin, liver, melanoma skin, pancreas myelodysplastic syndrome, biliary, stomach, and other neuroendocrine tumors  \n WJCO  [https://www.wjgnet.com](https://www.wjgnet.com) 1048 August 24, 2024  Volume 15  Issue 8   \nHaider MB et al. MN in CeD patients  \n(excluding small and large intestine malignant carcinoid), leukemia, uterus, and testis. Conversely, CeD patients exhibited a reduced risk of respiratory and secondary malignancies. Moreover, certain malignancies showed null associations with CeD, including head and neck, nervous system, esophagus, colorectal, anus, breast, malignant carcinoids, bone and connective tissues, myeloma, cervix, and ovary cancers.  \nCONCLUSION  \nOur study is unique in highlighting the detailed results of positive, negative, or null associations between different hematologic and solid malignancies and CeD. Furthermore, it offers insights into evolving trends in CeD hospital outcomes, shedding light on advancements in its management over the past two decades. These findings contribute valuable information to the understanding of CeD’s impact on health and healthcare utilization.  \nKey Words: Celiac disease; Malignant neoplasm; Autoimmune disorder; Hospitalized patients; Healthcare utilization; Gastrointestinal malignancies; Lymphomas; Epidemiology  \n©The Author(s) 2024. Published by","cbCaipYC40LCBv7v","https://ap.wps.com/l/cbCaipYC40LCBv7v","pdf",1240457,14,"English","# Abstract\n## Background\n## Aim\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What is the study aim regarding celiac disease and malignant neoplasms?\",\"answer\":\"To investigate the prevalence of malignant neoplasms in hospitalized celiac disease patients in the United States.\"},{\"question\":\"What data and study period were used to identify the celiac disease cohort?\",\"answer\":\"Data from the National Inpatient Sample spanning two decades, from January 2000 to December 2019, were used to identify 529,842 celiac disease patients.\"},{\"question\":\"How were celiac disease patients compared with the general non-CeD population?\",\"answer\":\"Propensity score matching was applied using age, sex, race, and calendar year at a 1:1 ratio between celiac disease patients and non-CeD patients.\"}]","Prevalence of malignant neoplasms in celiac disease patients - a nationwide United States population-based study - Observational study | PDF",1790003564,35]